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Aspa aspartoacylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 79251, updated on 11-Apr-2024

Summary

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Official Symbol
Aspaprovided by RGD
Official Full Name
aspartoacylaseprovided by RGD
Primary source
RGD:621693
See related
Ensembl:ENSRNOG00000019659 AllianceGenome:RGD:621693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables identical protein binding activity. Involved in central nervous system myelination and positive regulation of oligodendrocyte differentiation. Located in cytoplasm and nucleus. Used to study Canavan disease. Human ortholog(s) of this gene implicated in Canavan disease. Orthologous to human ASPA (aspartoacylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 460.7), Brain (RPKM 63.0) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (58390204..58443790, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (57891704..57945267, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59839693..59888244, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene sedoheptulokinase Neighboring gene transient receptor potential cation channel, subfamily V, member 1 Neighboring gene transient receptor potential cation channel, subfamily V, member 3 Neighboring gene spermatogenesis associated 22 Neighboring gene olfactory receptor family 1 subfamily E member 1 Neighboring gene olfactory receptor family 1 subfamily E member 1C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Involvement of aspartoacylase in tremor expression in rats. Nishitani A, et al. Exp Anim, 2016 Jul 29. PMID 27026062, Free PMC Article
  2. Extensive aspartoacylase expression in the rat central nervous system. Moffett JR, et al. Glia, 2011 Oct. PMID 21598311, Free PMC Article
  3. Novel role for aspartoacylase in regulation of BDNF and timing of postnatal oligodendrogenesis. Francis JS, et al. J Neurosci Res, 2006 Jul. PMID 16634055
  4. Effects of AAV-2-mediated aspartoacylase gene transfer in the tremor rat model of Canavan disease. McPhee SW, et al. Brain Res Mol Brain Res, 2005 Apr 27. PMID 15857674
  5. Immunohistochemical localization of aspartoacylase in the rat central nervous system. Madhavarao CN, et al. J Comp Neurol, 2004 May 3. PMID 15065127

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction of N-acetyl-L-aspartate accumulation due to ASPA deficiency with an unstable neuronal membrane potential caused by HCN1 deficiency was involved in tremor development.
    Title: Involvement of aspartoacylase in tremor expression in rats.
  2. The decrease in N-acetylaspartate following severe traumatic brain injury was characterized by profound mitochondrial malfunctioning, dramatic repression of Nat8l gene and concomitant increase in the ASPA gene and protein levels.
    Title: The molecular mechanisms affecting N-acetylaspartate homeostasis following experimental graded traumatic brain injury.
  3. This study demonistrated that aspartoacylase expression in the rat white matter central nervous system.
    Title: Extensive aspartoacylase expression in the rat central nervous system.
  4. The develomental increase of this enzyme in oligodendrocytes parallels CNS myelination.
    Title: Developmental increase of aspartoacylase in oligodendrocytes parallels CNS myelination.
  5. the N-terminal domain of aspartoacylase adopts a protein fold similar to that of zinc-dependent hydrolases related to carboxypeptidases A
    Title: Structure of aspartoacylase, the brain enzyme impaired in Canavan disease.
  6. ASPA colocalized throughout the brain with CC1, a marker for oligodendrocytes, with 92-98% of CC1-positive cells also reactive with the ASPA antibody.
    Title: Immunohistochemical localization of aspartoacylase in the rat central nervous system.
  7. describe the occurrence of ASPA within nuclei of rat brain and kidney, and in cultured rodent oligodendrocytes.
    Title: Aspartoacylase is a regulated nuclear-cytoplasmic enzyme.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93407, MGC93408

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aspartoacylase activity ISO
Inferred from Sequence Orthology
more info
  
enables aspartoacylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables aspartoacylase activity TAS
Traceable Author Statement
more info
 PubMed 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in aspartate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in central nervous system myelination IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aspartoacylase
Names
ACY-2
aminoacylase-2
NP_077375.2
XP_006246880.1
XP_017453032.1
XP_038942843.1
XP_038942844.1
XP_038942846.1
XP_038942847.1
XP_063125987.1
XP_063125988.1
XP_063125989.1
XP_063125990.1
XP_063125991.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024399.2 → NP_077375.2  aspartoacylase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q6AZ03, Q9R1T5
    UniProtKB/TrEMBL
    A0A8L2RC31, A6HGJ6
    Conserved Domains (1) summary
    cl11393
    Location:10 → 299
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    58390204..58443790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269919.1 → XP_063125989.1  aspartoacylase isoform X4

    UniProtKB/TrEMBL
    A0A1W2Q5Z4, A6HGJ4

  2. XM_063269918.1 → XP_063125988.1  aspartoacylase isoform X4

    UniProtKB/TrEMBL
    A0A1W2Q5Z4, A6HGJ4

  3. XM_039086919.2 → XP_038942847.1  aspartoacylase isoform X6

    UniProtKB/TrEMBL
    A0A8I6ATJ0
    Conserved Domains (1) summary
    cd06909
    Location:11 → 192
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily

  4. XM_063269921.1 → XP_063125991.1  aspartoacylase isoform X7

  5. XM_006246818.5 → XP_006246880.1  aspartoacylase isoform X3

    UniProtKB/TrEMBL
    A0A1W2Q6K0, A0A8I6ATJ0
    Related
    ENSRNOP00000076282.1
    Conserved Domains (2) summary
    cd06909
    Location:11 → 248
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
    pfam04952
    Location:9 → 247
    AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family

  6. XM_039086915.2 → XP_038942843.1  aspartoacylase isoform X1

    UniProtKB/Swiss-Prot
    Q6AZ03, Q9R1T5
    UniProtKB/TrEMBL
    A0A8L2RC31, A6HGJ6
    Related
    ENSRNOP00000072876.1
    Conserved Domains (1) summary
    cl11393
    Location:10 → 299
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

  7. XM_063269917.1 → XP_063125987.1  aspartoacylase isoform X2

  8. XM_039086916.2 → XP_038942844.1  aspartoacylase isoform X1

    UniProtKB/Swiss-Prot
    Q6AZ03, Q9R1T5
    UniProtKB/TrEMBL
    A0A8L2RC31, A6HGJ6
    Conserved Domains (1) summary
    cl11393
    Location:10 → 299
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

  9. XM_017597543.3 → XP_017453032.1  aspartoacylase isoform X2

    UniProtKB/TrEMBL
    A0A8L2RC31

  10. XM_063269920.1 → XP_063125990.1  aspartoacylase isoform X5

    UniProtKB/TrEMBL
    A0A0H2UHY8

  11. XM_039086918.2 → XP_038942846.1  aspartoacylase isoform X5

    UniProtKB/TrEMBL
    A0A0H2UHY8, A0A8I6ATJ0
    Related
    ENSRNOP00000050760.5
    Conserved Domains (1) summary
    cd06909
    Location:11 → 205
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily

RNA

  1. XR_010055268.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1T5.2 GenPept UniProtKB/Swiss-Prot:Q9R1T5

Gene LinkOut

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