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Grid2 glutamate ionotropic receptor delta type subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79220, updated on 13-Apr-2024

Summary

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Official Symbol
Grid2provided by RGD
Official Full Name
glutamate ionotropic receptor delta type subunit 2provided by RGD
Primary source
RGD:68368
See related
Ensembl:ENSRNOG00000006174 AllianceGenome:RGD:68368
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GluD2
Summary
Enables PDZ domain binding activity and identical protein binding activity. Involved in regulation of presynapse assembly. Located in postsynaptic density and postsynaptic membrane. Is active in glutamatergic synapse and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 18. Orthologous to human GRID2 (glutamate ionotropic receptor delta type subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 124.3), Uterus (RPKM 34.3) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
4q31
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (93745165..95222354)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (92415019..93892472)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (94068112..95476864)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene histidine triad nucleotide binding protein 1, pseudogene 1 Neighboring gene thyroid stimulating hormone receptor, pseudogene 1 Neighboring gene uncharacterized LOC120102493 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120102494 Neighboring gene U7 small nuclear RNA Neighboring gene atonal bHLH transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The architecture of GluD2 ionotropic delta glutamate receptor elucidated by cryo-EM. Burada AP, et al. J Struct Biol, 2020 Aug 1. PMID 32512155
  2. The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region. Tapken D, et al. Sci Rep, 2017 Apr 7. PMID 28387240, Free PMC Article
  3. Regulation of long-term depression and climbing fiber territory by glutamate receptor delta2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells. Uemura T, et al. J Neurosci, 2007 Oct 31. PMID 17978051, Free PMC Article
  4. Ionotropic glutamate-like receptor delta2 binds D-serine and glycine. Naur P, et al. Proc Natl Acad Sci U S A, 2007 Aug 28. PMID 17715062, Free PMC Article
  5. Motor coordination in mice with hotfoot, Lurcher, and double mutations of the Grid2 gene encoding the delta-2 excitatory amino acid receptor. Lalonde R, et al. Physiol Behav, 2003 Nov. PMID 14637233

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The architecture of GluD2 ionotropic delta glutamate receptor elucidated by cryo-EM.
    Title: The architecture of GluD2 ionotropic delta glutamate receptor elucidated by cryo-EM.
  2. the hinge region connecting the two subdomains of the GluD2 ligand-binding domain is responsible for the low affinity of D-serine.
    Title: The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region.
  3. Results determined the crystal structures of the trimeric C1q-like domain of cerebellin-1, and the first complete ectodomain of GluD2. Cerebellin binds to the LNS6 domain of alpha- and beta-neurexin-1 through a high-affinity interaction that involves its highly flexible N-terminal domain.
    Title: Conformational Plasticity in the Transsynaptic Neurexin-Cerebellin-Glutamate Receptor Adhesion Complex.
  4. study supports the hypothesis that developmental hypothyroxinemia and hypothyroidism reduce PF-PC synapses, which may be attributed to the downregulation of Neurexin1/Cbln1/GluD2 tripartite complex.
    Title: Developmental Hypothyroxinemia and Hypothyroidism Reduce Parallel Fiber-Purkinje Cell Synapses in Rat Offspring by Downregulation of Neurexin1/Cbln1/GluD2 Tripartite Complex.
  5. study found that Cbln1 binds directly to the N-terminal domain of glutamate receptor delta2 (GluD2); results indicate that the Cbln1-GluD2 complex is a unique synapse organizer that acts bidirectionally on both pre- and postsynaptic components
    Title: Cbln1 is a ligand for an orphan glutamate receptor delta2, a bidirectional synapse organizer.
  6. These results suggest that the C-terminal T site of GluR2 is essential for LTD induction and the regulation of CF territory but is dispensable for PF-PC synapse formation and the elimination of surplus CFs at proximal dendrites during development.
    Title: Regulation of long-term depression and climbing fiber territory by glutamate receptor delta2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells.
  7. the interaction between delta2 receptor and S-SCAM/MAGI-2 may be important for intracellular trafficking of the receptor
    Title: PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein.
  8. The performance of Grid2(ho/ho) mutant mice was poorer than that of controls on stationary beam, coat hanger, unsteady platform, and rotorod tests. Grid2(ho/Lc) did not differ from Grid2(Lc/+) mice.
    Title: Motor coordination in mice with hotfoot, Lurcher, and double mutations of the Grid2 gene encoding the delta-2 excitatory amino acid receptor.
  9. findings show that glutamate receptor delta2 interacted directly with AP-4; results suggest a potential involvement of AP-4 in the trafficking of delta2 in the brain
    Title: Adaptor protein complex-4 (AP-4) is expressed in the central nervous system neurons and interacts with glutamate receptor delta2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cerebellar granule cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cerebellar granule cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
  
involved_in excitatory synapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of long-term synaptic depression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within prepulse inhibition ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic density assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of presynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of presynapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
part_of ionotropic glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutamate receptor ionotropic, delta-2
Names
gluR delta-2 subunit
glutamate receptor delta-2 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024379.2 → NP_077355.2  glutamate receptor ionotropic, delta-2 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q62641, Q63226
    UniProtKB/TrEMBL
    A6KF16, F1LXB6
    Related
    ENSRNOP00000084985.1, ENSRNOT00000116787.1
    Conserved Domains (2) summary
    cd13731
    Location:440 → 806
    PBP2_iGluR_delta_2; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-2, a member of the type 2 periplasmic-binding fold protein superfamily
    cl10011
    Location:28 → 429
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    93745165..95222354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017592903.3 → XP_017448392.1  glutamate receptor ionotropic, delta-2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AR77, F1LXB6
    Related
    ENSRNOP00000096742.1

  2. XM_039108399.2 → XP_038964327.1  glutamate receptor ionotropic, delta-2 isoform X2

    UniProtKB/TrEMBL
    F1LXB6
    Conserved Domains (2) summary
    cd13731
    Location:440 → 806
    PBP2_iGluR_delta_2; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-2, a member of the type 2 periplasmic-binding fold protein superfamily
    cl10011
    Location:28 → 429
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63226.2 GenPept UniProtKB/Swiss-Prot:Q63226

Gene LinkOut

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