Mtpn myotrophin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mtpnprovided by RGD
Official Full Name: myotrophinprovided by RGD
Primary source: RGD:619806
See related: Ensembl:ENSRNOG00000011857 AllianceGenome:RGD:619806
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gcdp
Summary: Enables sequence-specific DNA binding activity. Involved in several processes, including cellular response to mechanical stimulus; cerebellar granule cell differentiation; and regulation of macromolecule biosynthetic process. Located in axon; cytosol; and nucleus. Used to study hypertension. Biomarker of hypertension. Orthologous to human MTPN (myotrophin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 514.8), Spleen (RPKM 475.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (65126390..65153803, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (64159273..64186686, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (63012009..63039422, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

after internalization into myocytes, myotrophin cotranslocates into the nucleus with p65 to stimulate myocyte growth.
Title: Nuclear co-translocation of myotrophin and p65 stimulates myocyte growth. Regulation by myotrophin hairpin loops.
characterisation of the small ankyrin repeat protein myotrophin
Title: Biophysical characterisation of the small ankyrin repeat protein myotrophin.
Data strongly suggest that myotrophin appears to be a candidate gene for cardiac hypertrophy and heart failure.
Title: Characterization and functional significance of myotrophin: a gene with multiple transcripts.
role in controlling catecholamine secretion in PC12D cells
Title: V-1, a catecholamine biosynthesis regulatory protein, positively controls catecholamine secretion in PC12D cells.
regulates catecholamine biosynthesis in a catecholaminergic phenotype-dependent manner
Title: Glucocorticoid inhibits expression of V-1, a catecholamine biosynthesis regulatory protein, in cultured adrenal medullary cells.
V-1 expression is increased by hypertension in DS rat atrium.
Title: Expression of V-1, a novel catecholamine biosynthesis regulatory protein, is enhanced by hypertension in atrial myocytes of Dahl salt-sensitive rats.
V-1 plays a role in prenatal muscle differentiation and postnatal muscle regeneration.
Title: Down-regulation of an ankyrin repeat-containing protein, V-1, during skeletal muscle differentiation and its re-expression in the regenerative process of muscular dystrophy.
stretching of cardiac myocytes by pressure or volume caused significant increase in the transcript levels of myotrophin , which in turn is responsible for the initiation process of myocardial hypertrophy
Title: Regulation of myotrophin gene by pressure overload and stretch.
expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein
Title: V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein.
Results suggest that myotrophin V1 is a predominantly cytosolic protein that could regulate the NFkappa-beta mediated transcription process.
Title: Myotrophin/V-1 does not act as an extracellular signal to induce myocyte hypertrophy.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

RH134386 (e-PCR)
- UniSTS:217668

RH142541 (e-PCR)
- UniSTS:231788

RH135242 (e-PCR)
- UniSTS:218519

Mtpn (e-PCR), detects polymorphism
- UniSTS:507074

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in catecholamine metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebellar granule cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuron differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cardiac muscle hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macromolecule biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of barbed-end actin filament capping	ISO Inferred from Sequence Orthology more info
involved_in regulation of barbed-end actin filament capping	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in striated muscle cell differentiation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of F-actin capping protein complex	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myotrophin

Names: V-1 protein; granule cell differentiation protein; growth factor; protein V-1; stimulates myocyte growth

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.