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Tnfrsf23 tumor necrosis factor receptor superfamily, member 23 [ Mus musculus (house mouse) ]

Gene ID: 79201, updated on 8-Feb-2024

Summary

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Official Symbol
Tnfrsf23provided by MGI
Official Full Name
tumor necrosis factor receptor superfamily, member 23provided by MGI
Primary source
MGI:MGI:1930269
See related
Ensembl:ENSMUSG00000037613 AllianceGenome:MGI:1930269
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SOB; mSOB; Tnfrh1; TNFRSFH23; Tnfrsf1al1; mDcTRAILR1
Summary
This gene encodes a member of the tumor necrosis factor superfamily of proteins. The encoded receptor has been shown to bind to the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), but to have no signaling capacity. This gene shows elevated expression in mice with diet-induced fatty liver disease. This gene and other family members are present in a gene cluster on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in placenta adult (RPKM 2.4), subcutaneous fat pad adult (RPKM 2.1) and 27 other tissues See more
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Genomic context

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See Tnfrsf23 in Genome Data Viewer
Location:
7 F5; 7 88.28 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143219544..143239836, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143665807..143686436, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor receptor superfamily, member 26 Neighboring gene RIKEN cDNA E230032D23 gene Neighboring gene STARR-positive B cell enhancer ABC_E6618 Neighboring gene STARR-seq mESC enhancer starr_20534 Neighboring gene tumor necrosis factor receptor superfamily, member 22 Neighboring gene STARR-positive B cell enhancer ABC_E10486 Neighboring gene oxysterol binding protein-like 5 Neighboring gene STARR-positive B cell enhancer ABC_E2256 Neighboring gene STARR-positive B cell enhancer ABC_E3762 Neighboring gene MAS-related GPR, member G

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression. Farrell GC, et al. J Gastroenterol Hepatol, 2009 Mar. PMID 19226377
  2. A genomic reservoir for Tnfrsf genes is developmentally regulated and imprinted in the mouse. de la Casa Esperón E, et al. Epigenetics, 2012 Jun 1. PMID 22595876, Free PMC Article
  3. The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface. Clark L, et al. BMC Genet, 2002 Jun 27. PMID 12102730, Free PMC Article
  4. Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Schneider P, et al. J Biol Chem, 2003 Feb 14. PMID 12466268
  5. Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH. Mahy NL, et al. J Cell Biol, 2002 Dec 9. PMID 12473685, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Apoptosis in experimental non-alcoholic steatohepatitis is associated with p53 activation and TRAIL receptor expression.
    Title: Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression.
  2. The Tnfrh1 gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface.
    Title: The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC123882, MGC123883

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tumor necrosis factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in activation-induced cell death of T cells IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in motor neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in necroptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of stress-activated MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CD95 death-inducing signaling complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 23
Names
TNF receptor family member SOB
TNF receptor homolog 1
decoy TRAIL receptor 1
tumor necrosis factor receptor p60 homolog 1
tumor necrosis factor receptor superfamily, member 1a-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308111.1 → NP_001295040.1  tumor necrosis factor receptor superfamily member 23 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001295040.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, resulting in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC068006, BG077775, BP768617, BY036522, BY201915
    Consensus CDS
    CCDS85480.1
    UniProtKB/TrEMBL
    A0A140LIU0
    Related
    ENSMUSP00000146956.2, ENSMUST00000208017.2
    Conserved Domains (1) summary
    cl22855
    Location:38 → 98
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  2. NM_024290.4 → NP_077252.2  tumor necrosis factor receptor superfamily member 23 isoform 1 precursor

    See identical proteins and their annotated locations for NP_077252.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC068006, BG077775, BP768617, BY036522, BY201915
    Consensus CDS
    CCDS22044.1
    UniProtKB/Swiss-Prot
    Q8VHC0, Q9ER63
    UniProtKB/TrEMBL
    Q3U3F7
    Related
    ENSMUSP00000116742.2, ENSMUST00000152703.2
    Conserved Domains (1) summary
    cd15837
    Location:38 → 155
    TNFRSF26; Tumor necrosis factor receptor superfamily member 26 (TNFRSF26), also known as tumor necrosis factor receptor homolog 3 (TNFRH3)

RNA

  1. NR_131763.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC068006, BG077775, BP768617, BY036522, BY201915
    Related
    ENSMUST00000035742.14

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    143219544..143239836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508661.4 → XP_006508724.1  tumor necrosis factor receptor superfamily member 23 isoform X3

    Conserved Domains (1) summary
    cd15837
    Location:38 → 155
    TNFRSF26; Tumor necrosis factor receptor superfamily member 26 (TNFRSF26), also known as tumor necrosis factor receptor homolog 3 (TNFRH3)

  2. XM_036153591.1 → XP_036009484.1  tumor necrosis factor receptor superfamily member 23 isoform X4

    Conserved Domains (1) summary
    cd15837
    Location:38 → 155
    TNFRSF26; Tumor necrosis factor receptor superfamily member 26 (TNFRSF26), also known as tumor necrosis factor receptor homolog 3 (TNFRH3)

  3. XM_036153590.1 → XP_036009483.1  tumor necrosis factor receptor superfamily member 23 isoform X2

    Conserved Domains (1) summary
    cd15837
    Location:38 → 155
    TNFRSF26; Tumor necrosis factor receptor superfamily member 26 (TNFRSF26), also known as tumor necrosis factor receptor homolog 3 (TNFRH3)

  4. XM_006508660.5 → XP_006508723.1  tumor necrosis factor receptor superfamily member 23 isoform X1

    Conserved Domains (1) summary
    cd15837
    Location:38 → 155
    TNFRSF26; Tumor necrosis factor receptor superfamily member 26 (TNFRSF26), also known as tumor necrosis factor receptor homolog 3 (TNFRH3)

RNA

  1. XR_004934224.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ER63.2 GenPept UniProtKB/Swiss-Prot:Q9ER63

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