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CAMKV CaM kinase like vesicle associated [ Homo sapiens (human) ]

Gene ID: 79012, updated on 5-Mar-2024

Summary

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Official Symbol
CAMKVprovided by HGNC
Official Full Name
CaM kinase like vesicle associatedprovided by HGNC
Primary source
HGNC:HGNC:28788
See related
Ensembl:ENSG00000164076 MIM:614993; AllianceGenome:HGNC:28788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
1G5; VACAMKL
Summary
Predicted to enable calmodulin binding activity and calmodulin-dependent protein kinase activity. Predicted to be involved in peptidyl-serine phosphorylation. Predicted to be located in cytoplasmic vesicle membrane and plasma membrane. Predicted to be active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward brain (RPKM 33.0) See more
Orthologs
mouse all
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Genomic context

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See CAMKV in Genome Data Viewer
Location:
3p21.31
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (49857989..49869906, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (49887886..49899806, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (49895422..49907339, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49844839-49845735 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49848893-49849392 Neighboring gene microRNA 5193 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19880 Neighboring gene ubiquitin like modifier activating enzyme 7 Neighboring gene TRAF interacting protein Neighboring gene RNA, 7SL, cytoplasmic 217, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49905159-49906091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49906092-49907023 Neighboring gene actin like 11, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49921589-49922090 Neighboring gene macrophage stimulating 1 receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49934943-49935443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49939657-49940330 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:49940331-49941004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14376

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. 1G5: a calmodulin-binding, vesicle-associated, protein kinase-like protein enriched in forebrain neurites. Godbout M, et al. J Neurosci, 1994 Jan. PMID 8283228, Free PMC Article
  2. The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines. Liang Z, et al. Nat Commun, 2016 Oct 31. PMID 27796283, Free PMC Article
  3. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. So HC, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jan 5. PMID 19367581
  4. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Taipale M, et al. Cell, 2012 Aug 31. PMID 22939624, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC8407

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of modification of postsynaptic structure IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
caM kinase-like vesicle-associated protein
Names
testis tissue sperm-binding protein Li 52e
vesicle-associated calmodulin-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320147.2 → NP_001307076.1  caM kinase-like vesicle-associated protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different 3' structure compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK074899, BC001921
    Consensus CDS
    CCDS82776.1
    UniProtKB/TrEMBL
    B2RDF9
    Related
    ENSP00000418809.1, ENST00000488336.5
    Conserved Domains (3) summary
    smart00220
    Location:24 → 286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart01104
    Location:347 → 451
    CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
    cd14088
    Location:22 → 286
    STKc_CaMK_like; Catalytic domain of an Uncharacterized group of Serine/Threonine kinases with similarity to Calcium/calmodulin-dependent protein kinases

  2. NM_024046.5 → NP_076951.2  caM kinase-like vesicle-associated protein isoform 1

    See identical proteins and their annotated locations for NP_076951.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK074856, BC017363
    Consensus CDS
    CCDS33762.1
    UniProtKB/Swiss-Prot
    A6NFD4, Q6FIB8, Q8NBS8, Q8NC85, Q8NCB2, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5
    UniProtKB/TrEMBL
    A0A140VKD5, B2RDF9
    Related
    ENSP00000419195.1, ENST00000477224.6
    Conserved Domains (2) summary
    smart00220
    Location:24 → 286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14088
    Location:22 → 286
    STKc_CaMK_like; Catalytic domain of an Uncharacterized group of Serine/Threonine kinases with similarity to Calcium/calmodulin-dependent protein kinases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    49857989..49869906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    49887886..49899806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NCB2.2 GenPept UniProtKB/Swiss-Prot:Q8NCB2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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