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TRIR telomerase RNA component interacting RNase [ Homo sapiens (human) ]

Gene ID: 79002, updated on 5-Mar-2024

Summary

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Official Symbol
TRIRprovided by HGNC
Official Full Name
telomerase RNA component interacting RNaseprovided by HGNC
Primary source
HGNC:HGNC:28424
See related
Ensembl:ENSG00000123144 AllianceGenome:HGNC:28424
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TERCIR; fSAP18; C19orf43
Summary
Enables 3'-5' exonuclease activity and 5'-3' exonuclease activity. Involved in RNA phosphodiester bond hydrolysis, exonucleolytic and rRNA catabolic process. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 63.1), colon (RPKM 57.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12730640..12734684, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12855132..12859177, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12841454..12845498, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12814259-12814867 Neighboring gene transportin 2 Neighboring gene small nucleolar RNA, C/D box 135 Neighboring gene small nucleolar RNA, C/D box 41 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10157 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10158 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12832661-12833279 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12833280-12833897 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12833898-12834516 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12834517-12835133 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12842300-12842847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10160 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10161 Neighboring gene CRISPRi-FlowFISH-validated RAD23A regulatory element 1 Neighboring gene CRISPRi-FlowFISH-validated TRIR regulatory element Neighboring gene guided entry of tail-anchored proteins factor 3, ATPase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12855878-12856378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10166 Neighboring gene bestrophin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of an RNase that preferentially cleaves A/G nucleotides. Xie J, et al. Sci Rep, 2017 Mar 21. PMID 28322335, Free PMC Article
  2. Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding. Huang X, et al. J Biol Chem, 2019 Aug 16. PMID 31248990, Free PMC Article
  3. Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. Kim H, et al. Mol Cell, 2014 Apr 10. PMID 24657165, Free PMC Article
  4. Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. Behzadnia N, et al. EMBO J, 2007 Mar 21. PMID 17332742, Free PMC Article
  5. TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1. Le Guerroué F, et al. Mol Cell, 2023 Mar 16. PMID 36898370, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2803

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-5' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5' exonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-3' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-3' exonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in rRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
telomerase RNA component interacting RNase
Names
My029 protein
exoribonuclease TRIR
uncharacterized protein C19orf43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329738.2 → NP_001316667.1  telomerase RNA component interacting RNase isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC000216, BQ668685, BU599327
    Consensus CDS
    CCDS86709.1
    UniProtKB/TrEMBL
    B2RE11, K7EN60
    Related
    ENSP00000466801.1, ENST00000592273.5

  2. NM_001329739.2 → NP_001316668.1  telomerase RNA component interacting RNase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site, which results in a frameshift, compared to variant 1. The encoded protein (isoform 3) has a distinct, shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AC018761
    Consensus CDS
    CCDS86710.1
    UniProtKB/TrEMBL
    K7ELS0
    Related
    ENSP00000466196.1, ENST00000588213.1

  3. NM_024038.4 → NP_076943.1  telomerase RNA component interacting RNase isoform 1

    See identical proteins and their annotated locations for NP_076943.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (1).
    Source sequence(s)
    BC000216
    Consensus CDS
    CCDS12279.1
    UniProtKB/Swiss-Prot
    Q9BQ61
    UniProtKB/TrEMBL
    B2RE11
    Related
    ENSP00000242784.3, ENST00000242784.5

RNA

  1. NR_138095.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC000216, BM554534, BQ668685
    Related
    ENST00000591254.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    12730640..12734684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    12855132..12859177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BQ61.1 GenPept UniProtKB/Swiss-Prot:Q9BQ61

Gene LinkOut

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