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CYREN cell cycle regulator of NHEJ [ Homo sapiens (human) ]

Gene ID: 78996, updated on 3-Apr-2024

Summary

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Official Symbol
CYRENprovided by HGNC
Official Full Name
cell cycle regulator of NHEJprovided by HGNC
Primary source
HGNC:HGNC:22432
See related
Ensembl:ENSG00000122783 MIM:616980; AllianceGenome:HGNC:22432
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRI; MRI-2; C7orf49; CYREN-1; CYREN-2
Summary
Involved in double-strand break repair via nonhomologous end joining and negative regulation of double-strand break repair via nonhomologous end joining. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung (RPKM 6.0), spleen (RPKM 6.0) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
7q33
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (135092303..135172469, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (136400107..136478562, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134777061..134855459, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901750 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:134426881-134427534 Neighboring gene tubulin beta 3 class III pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:134469373-134469873 Neighboring gene caldesmon 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:134529756-134530955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18674 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134622660-134622865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26695 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26697 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26699 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26701 Neighboring gene AGBL carboxypeptidase 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:134760279-134760886 Neighboring gene MPRA-validated peak6750 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26708 Neighboring gene RNF14 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26711 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:134877948-134879147 Neighboring gene transmembrane protein 140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26712 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134888580-134888794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18677 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:134893611-134894810 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26713 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134935285-134935435 Neighboring gene WD repeat domain 91 Neighboring gene microRNA 6509 Neighboring gene uncharacterized LOC107984123 Neighboring gene stimulated by retinoic acid 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins. Grundy GJ, et al. Nat Commun, 2016 Apr 11. PMID 27063109, Free PMC Article
  2. Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN. Arnoult N, et al. Nature, 2017 Sep 20. PMID 28959974, Free PMC Article
  3. A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining. Slavoff SA, et al. J Biol Chem, 2014 Apr 18. PMID 24610814, Free PMC Article
  4. Isolation, characterization, and genetic complementation of a cellular mutant resistant to retroviral infection. Agarwal S, et al. Proc Natl Acad Sci U S A, 2006 Oct 24. PMID 17043244, Free PMC Article
  5. Developmental changes in the transcriptome of human cerebral cortex tissue: long noncoding RNA transcripts. Lipovich L, et al. Cereb Cortex, 2014 Jun. PMID 23377288

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. proposition that CYREN is a direct cell-cycle-dependent inhibitor of cNHEJ that promotes error-free repair by homologous recombination during cell cycle phases when sister chromatids are present
    Title: Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN.
  2. Interacts with Ku and enhances efficiency of DNA double strand break ligation in vitro
    Title: A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining.
  3. Characterizes the hamster ortholog and suggests that it may modulate the ability of the proteasome to degrade retroviral cores upon cellular infection.
    Title: Isolation, characterization, and genetic complementation of a cellular mutant resistant to retroviral infection.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC5242, FLJ22450, FLJ27285

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via nonhomologous end joining IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in immunoglobulin V(D)J recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of double-strand break repair via nonhomologous end joining IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cell cycle regulator of non-homologous end joining
Names
modulator of retrovirus infection homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243749.2 → NP_001230678.1  cell cycle regulator of non-homologous end joining isoform 2

    See identical proteins and their annotated locations for NP_001230678.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. Variants 2, 3, 4 and 5 encode the same small ORF (sORF)-encoded polypeptide (SEP) (isoform 2, also known as MRI-2), which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK026103, BC000168, CB961457
    Consensus CDS
    CCDS75663.1
    UniProtKB/TrEMBL
    C9JKC7

  2. NM_001243751.2 → NP_001230680.1  cell cycle regulator of non-homologous end joining isoform 2

    See identical proteins and their annotated locations for NP_001230680.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. Variants 2, 3, 4 and 5 encode the same small ORF (sORF)-encoded polypeptide (SEP) (isoform 2, also known as MRI-2), which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC000168, BC067350, CB961457
    Consensus CDS
    CCDS75663.1
    UniProtKB/TrEMBL
    C9JKC7
    Related
    ENSP00000389941.2, ENST00000430372.1

  3. NM_001243752.2 → NP_001230681.1  cell cycle regulator of non-homologous end joining isoform 2

    See identical proteins and their annotated locations for NP_001230681.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. Variants 2, 3, 4 and 5 encode the same small ORF (sORF)-encoded polypeptide (SEP) (isoform 2, also known as MRI-2), which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC083862, AI632984, BC000168, BE674385, BM727569, DA213716
    Consensus CDS
    CCDS75663.1
    UniProtKB/TrEMBL
    C9JKC7
    Related
    ENSP00000480430.1, ENST00000617987.1

  4. NM_001243753.2 → NP_001230682.1  cell cycle regulator of non-homologous end joining isoform 2

    See identical proteins and their annotated locations for NP_001230682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. Variants 2, 3, 4 and 5 encode the same small ORF (sORF)-encoded polypeptide (SEP) (isoform 2, also known as MRI-2), which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC083862, BC000168, BG770658
    Consensus CDS
    CCDS75663.1
    UniProtKB/TrEMBL
    C9JKC7

  5. NM_001243754.2 → NP_001230683.1  cell cycle regulator of non-homologous end joining isoform 3

    See identical proteins and their annotated locations for NP_001230683.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 6 and 7 encode the same isoform (3), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC000168, BQ423284
    Consensus CDS
    CCDS59082.1
    UniProtKB/Swiss-Prot
    Q9BWK5
    Related
    ENSP00000473365.1, ENST00000483029.2
    Conserved Domains (1) summary
    pfam15325
    Location:1 → 102
    MRI; Modulator of retrovirus infection

  6. NM_001243755.2 → NP_001230684.1  cell cycle regulator of non-homologous end joining isoform 3

    See identical proteins and their annotated locations for NP_001230684.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, uses an alternate splice site and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 6 and 7 encode the same isoform (3), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC083862, AL708733, BC000168
    Consensus CDS
    CCDS59082.1
    UniProtKB/Swiss-Prot
    Q9BWK5
    Related
    ENSP00000481014.1, ENST00000620897.4
    Conserved Domains (1) summary
    pfam15325
    Location:1 → 102
    MRI; Modulator of retrovirus infection

  7. NM_001305629.2 → NP_001292558.1  cell cycle regulator of non-homologous end joining isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site and lacks an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC083862, BC067350, HY026093
    UniProtKB/Swiss-Prot
    Q9BWK5
    Conserved Domains (1) summary
    pfam15325
    Location:59 → 144
    MRI; Modulator of retrovirus infection

  8. NM_001305630.2 → NP_001292559.1  cell cycle regulator of non-homologous end joining isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate splice site, lacks a portion of the 3' coding region, and contains an alternate 3' terminal exon, resulting in a distinct 3' UTR, compared to variant 1. The encoded isoform (5) has a shorter and distinct C-terminus than isoform 1.
    Source sequence(s)
    AC083862, AI335567, BC050676, CB961457
    UniProtKB/TrEMBL
    C9JKC7
    Related
    ENST00000459937.5

  9. NM_001363329.2 → NP_001350258.1  cell cycle regulator of non-homologous end joining isoform 1

    Status: VALIDATED

    Source sequence(s)
    BC000168, BP213903, CB132932
    Consensus CDS
    CCDS5838.2
    UniProtKB/Swiss-Prot
    A0A024R780, A0A087WWQ8, Q6NWZ4, Q6ZNR5, Q9BWK5
    Conserved Domains (1) summary
    pfam15325
    Location:52 → 157
    MRI; Modulator of retrovirus infection

  10. NM_001363330.2 → NP_001350259.1  cell cycle regulator of non-homologous end joining isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC083862, BC000168, BE674385, BP213903, CB132932
    Consensus CDS
    CCDS5838.2
    UniProtKB/Swiss-Prot
    A0A024R780, A0A087WWQ8, Q6NWZ4, Q6ZNR5, Q9BWK5
    Conserved Domains (1) summary
    pfam15325
    Location:52 → 157
    MRI; Modulator of retrovirus infection

  11. NM_024033.4 → NP_076938.2  cell cycle regulator of non-homologous end joining isoform 1

    See identical proteins and their annotated locations for NP_076938.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1, also known as MRI-1).
    Source sequence(s)
    AC083862
    Consensus CDS
    CCDS5838.2
    UniProtKB/Swiss-Prot
    A0A024R780, A0A087WWQ8, Q6NWZ4, Q6ZNR5, Q9BWK5
    Related
    ENSP00000376823.3, ENST00000393114.8
    Conserved Domains (1) summary
    pfam15325
    Location:52 → 157
    MRI; Modulator of retrovirus infection

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    135092303..135172469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012595.2 → XP_016868084.1  cell cycle regulator of non-homologous end joining isoform X2

    UniProtKB/TrEMBL
    C9JKC7

  2. XM_017012591.3 → XP_016868080.1  cell cycle regulator of non-homologous end joining isoform X3

    UniProtKB/Swiss-Prot
    A0A024R780, A0A087WWQ8, Q6NWZ4, Q6ZNR5, Q9BWK5
    Conserved Domains (1) summary
    pfam15325
    Location:52 → 157
    MRI; Modulator of retrovirus infection

  3. XM_047420824.1 → XP_047276780.1  cell cycle regulator of non-homologous end joining isoform X1

  4. XM_017012592.3 → XP_016868081.1  cell cycle regulator of non-homologous end joining isoform X1

    Conserved Domains (1) summary
    pfam15325
    Location:59 → 144
    MRI; Modulator of retrovirus infection

  5. XM_047420823.1 → XP_047276779.1  cell cycle regulator of non-homologous end joining isoform X1

  6. XM_047420825.1 → XP_047276781.1  cell cycle regulator of non-homologous end joining isoform X2

  7. XM_047420826.1 → XP_047276782.1  cell cycle regulator of non-homologous end joining isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    136400107..136478562 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358988.1 → XP_054214963.1  cell cycle regulator of non-homologous end joining isoform X2

  2. XM_054358984.1 → XP_054214959.1  cell cycle regulator of non-homologous end joining isoform X1

  3. XM_054358985.1 → XP_054214960.1  cell cycle regulator of non-homologous end joining isoform X1

  4. XM_054358986.1 → XP_054214961.1  cell cycle regulator of non-homologous end joining isoform X2

  5. XM_054358987.1 → XP_054214962.1  cell cycle regulator of non-homologous end joining isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BWK5.2 GenPept UniProtKB/Swiss-Prot:Q9BWK5

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