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PCYOX1L prenylcysteine oxidase 1 like [ Homo sapiens (human) ]

Gene ID: 78991, updated on 5-Mar-2024

Summary

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Official Symbol
PCYOX1Lprovided by HGNC
Official Full Name
prenylcysteine oxidase 1 likeprovided by HGNC
Primary source
HGNC:HGNC:28477
See related
Ensembl:ENSG00000145882 AllianceGenome:HGNC:28477
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable prenylcysteine oxidase activity. Predicted to be involved in prenylated protein catabolic process. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 5.8), brain (RPKM 5.2) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
5q32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (149358046..149369653)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (149892861..149904468)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (148737609..148749216)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene actin filament associated protein 1 like 1 Neighboring gene uncharacterized LOC124901103 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:148724745-148725370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:148725371-148725994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148726519-148727019 Neighboring gene GRPEL2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 10017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16496 Neighboring gene GrpE like 2, mitochondrial Neighboring gene Sharpr-MPRA regulatory region 12528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:148746417-148747281 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:148747282-148748145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148759103-148759637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148759990-148760702 Neighboring gene uncharacterized LOC101927046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148762129-148762840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148764726-148765226 Neighboring gene interleukin 17B Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148784456-148785046 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:148786897-148787897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148790014-148790554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148790555-148791094 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82102 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82107 Neighboring gene VISTA enhancer hs1752 Neighboring gene cardiac mesoderm enhancer-associated non-coding RNA Neighboring gene microRNA 143

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities. Petenkova A, et al. Nat Commun, 2023 May 13. PMID 37179332, Free PMC Article
  2. TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination. Wang G, et al. Ann Rheum Dis, 2020 Aug. PMID 32409323, Free PMC Article
  3. Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan. Wong CK, et al. Mol Cancer Res, 2020 Mar. PMID 31932471, Free PMC Article
  4. Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies. Schiza C, et al. Mol Cell Proteomics, 2018 Dec. PMID 30097533, Free PMC Article
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. Zhang Z, et al. Protein Sci, 2004 Oct. PMID 15340161, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC3265

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables prenylcysteine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in prenylated protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prenylcysteine catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 
located_in platelet alpha granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
prenylcysteine oxidase-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301054.2 → NP_001287983.1  prenylcysteine oxidase-like isoform 2

    See identical proteins and their annotated locations for NP_001287983.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. It has an alternate splice site in the 5' region, which results in an alternate translation initiation site, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF451985, AK090410, DA368718, DB573610
    UniProtKB/TrEMBL
    E7EVZ5
    Related
    ENSP00000428512.1, ENST00000514349.1
    Conserved Domains (2) summary
    pfam07156
    Location:105 → 466
    Prenylcys_lyase; Prenylcysteine lyase
    pfam13450
    Location:14 → 79
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

  2. NM_001301057.2 → NP_001287986.1  prenylcysteine oxidase-like isoform 3

    See identical proteins and their annotated locations for NP_001287986.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the 5' region, which results in an alternate translation initiation site, and has an alternate in-frame splice site in the central region, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK090410, BC000014, DA368718, DB573610
    UniProtKB/TrEMBL
    E7EVZ5
    Conserved Domains (2) summary
    pfam07156
    Location:105 → 407
    Prenylcys_lyase; Prenylcysteine lyase
    pfam13450
    Location:14 → 79
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

  3. NM_024028.4 → NP_076933.3  prenylcysteine oxidase-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_076933.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK075414, BP397957, DA368718
    Consensus CDS
    CCDS4296.1
    UniProtKB/Swiss-Prot
    Q7Z4S2, Q8NBM8, Q8NCY5, Q8NF69, Q9BTE8, Q9BWS3
    UniProtKB/TrEMBL
    E7EVZ5
    Related
    ENSP00000274569.4, ENST00000274569.9
    Conserved Domains (2) summary
    pfam07156
    Location:122 → 483
    Prenylcys_lyase; Prenylcysteine lyase
    pfam13450
    Location:31 → 96
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    149358046..149369653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    149892861..149904468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NBM8.2 GenPept UniProtKB/Swiss-Prot:Q8NBM8

Gene LinkOut

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