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Popdc3 popeye domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 78977, updated on 5-Mar-2024

Summary

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Official Symbol
Popdc3provided by MGI
Official Full Name
popeye domain containing 3provided by MGI
Primary source
MGI:MGI:1930153
See related
Ensembl:ENSMUSG00000019848 AllianceGenome:MGI:1930153
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pop3
Summary
Enables cAMP binding activity. Acts upstream of or within regulation of membrane potential. Located in membrane. Is expressed in several structures, including gut; heart; leg muscle; male reproductive gland or organ; and nervous system. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy. Orthologous to human POPDC3 (popeye domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 5.6), bladder adult (RPKM 2.7) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Popdc3 in Genome Data Viewer
Location:
10 B2; 10 23.35 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (45165401..45194546)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (45289305..45318450)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26567 Neighboring gene STARR-seq mESC enhancer starr_26571 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:44823099-44823208 Neighboring gene prolyl endopeptidase Neighboring gene STARR-seq mESC enhancer starr_26573 Neighboring gene STARR-seq mESC enhancer starr_26574 Neighboring gene VISTA enhancer mm87 Neighboring gene STARR-seq mESC enhancer starr_26575 Neighboring gene predicted gene, 26016 Neighboring gene predicted gene 15934 Neighboring gene STARR-seq mESC enhancer starr_26577 Neighboring gene blood vessel epicardial substance Neighboring gene STARR-seq mESC enhancer starr_26578 Neighboring gene lin-28 homolog B Neighboring gene predicted gene, 51827

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Epigenetic patterns at the mouse prolyl oligopeptidase gene locus suggest the CpG island in the gene body to be a novel regulator for gene expression. Matsubara S, et al. Gene, 2010 Oct 1. PMID 20600704
  2. Mouse Pop1 is required for muscle regeneration in adult skeletal muscle. Andrée B, et al. Mol Cell Biol, 2002 Mar. PMID 11839816, Free PMC Article
  3. Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice. Froese A, et al. J Clin Invest, 2012 Mar. PMID 22354168, Free PMC Article
  4. Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart. Andrée B, et al. Dev Biol, 2000 Jul 15. PMID 10882522
  5. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC141238

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cAMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of membrane potential IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in skeletal muscle tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in striated muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
popeye domain-containing protein 3
Names
popeye 3
popeye protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024286.1 → NP_077248.1  popeye domain-containing protein 3

    See identical proteins and their annotated locations for NP_077248.1

    Status: VALIDATED

    Source sequence(s)
    AK052325
    Consensus CDS
    CCDS23827.1
    UniProtKB/Swiss-Prot
    Q1RME0, Q9ES81
    Related
    ENSMUSP00000019994.8, ENSMUST00000019994.14
    Conserved Domains (1) summary
    pfam04831
    Location:25 → 249
    Popeye; Popeye protein conserved region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    45165401..45194546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512931.5 → XP_006512994.1  popeye domain-containing protein 3 isoform X2

    Conserved Domains (1) summary
    pfam04831
    Location:34 → 196
    Popeye; Popeye protein conserved region

  2. XM_036156114.1 → XP_036012007.1  popeye domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q1RME0, Q9ES81
    Conserved Domains (1) summary
    pfam04831
    Location:25 → 249
    Popeye; Popeye protein conserved region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ES81.1 GenPept UniProtKB/Swiss-Prot:Q9ES81

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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