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Sp2 Sp2 transcription factor [ Mus musculus (house mouse) ]

Gene ID: 78912, updated on 5-Mar-2024

Summary

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Official Symbol
Sp2provided by MGI
Official Full Name
Sp2 transcription factorprovided by MGI
Primary source
MGI:MGI:1926162
See related
Ensembl:ENSMUSG00000018678 AllianceGenome:MGI:1926162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0048; 4930480I16Rik
Summary
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. The protein can act as a transcriptional activator or repressor, depending on the promoter and cell type. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thymus adult (RPKM 15.0), spleen adult (RPKM 11.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 60.17 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96844158..96873785, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96953332..96982959, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11525 Neighboring gene STARR-seq mESC enhancer starr_30572 Neighboring gene proline rich 15-like Neighboring gene RIKEN cDNA D030028A08 gene Neighboring gene STARR-positive B cell enhancer ABC_E2367 Neighboring gene pyridoxine 5'-phosphate oxidase Neighboring gene STARR-positive B cell enhancer ABC_E11488 Neighboring gene STARR-positive B cell enhancer ABC_E20 Neighboring gene STARR-seq mESC enhancer starr_30576 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:96849306-96849459 Neighboring gene predicted gene, 51916 Neighboring gene STARR-positive B cell enhancer ABC_E1429 Neighboring gene STARR-seq mESC enhancer starr_30578 Neighboring gene trans-acting transcription factor 6 Neighboring gene predicted gene 11532

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genome-wide localization and expression profiling establish Sp2 as a sequence-specific transcription factor regulating vitally important genes. Terrados G, et al. Nucleic Acids Res, 2012 Sep. PMID 22684502, Free PMC Article
  2. Overexpression of transcription factor sp2 inhibits epidermal differentiation and increases susceptibility to wound- and carcinogen-induced tumorigenesis. Kim TH, et al. Cancer Res, 2010 Nov 1. PMID 20959487, Free PMC Article
  3. Transcription of mouse Sp2 yields alternatively spliced and sub-genomic mRNAs in a tissue- and cell-type-specific fashion. Yin H, et al. Biochim Biophys Acta, 2010 Jul. PMID 20353838, Free PMC Article
  4. Regulation of inhibitor of differentiation gene 3 (Id3) expression by Sp2-motif binding factor in myogenic C2C12 cells: downregulation of DNA binding activity following skeletal muscle differentiation. Wu J, et al. Biochim Biophys Acta, 2005 Oct 15. PMID 16216350
  5. Sp2 DNA binding activity and trans-activation are negatively regulated in mammalian cells. Moorefield KS, et al. J Biol Chem, 2004 Apr 2. PMID 14726517

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. there is a stage-specific requirement for Sp2 in neural stem and progenitor cells in the mouse cortex
    Title: Sp2 regulates late neurogenic but not early expansive divisions of neural stem cells underlying population growth in the mouse cortex.
  2. a mechanism by which the DNA binding-independent activity of Sp2 potentiates genomic loading of Pbx1:Prep1 and Nf-y to composite motifs present in many promoters of highly expressed genes
    Title: Transcription factor Sp2 potentiates binding of the TALE homeoproteins Pbx1:Prep1 and the histone-fold domain protein Nf-y to composite genomic sites.
  3. SP2 as important factor responsible for higher Cd14 expression and reduced IBD susceptibility mediated by the C3Bir allele.
    Title: Transcription Factor SP2 Enhanced the Expression of Cd14 in Colitis-Susceptible C3H/HeJBir.
  4. Our results unveil strikingly different recruitment mechanisms of Sp1/Sp2/Sp3 transcription factor members uncovering an unexpected layer of complexity in their binding to chromatin in vivo.
    Title: Zinc finger independent genome-wide binding of Sp2 potentiates recruitment of histone-fold protein Nf-y distinguishing it from Sp1 and Sp3.
  5. Sp2 deletion disrupts neurogenesis in the embryonic and postnatal brain.
    Title: Neural development is dependent on the function of specificity protein 2 in cell cycle progression.
  6. Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts
    Title: Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts.
  7. Overexpression of transcription factor sp2 inhibits epidermal differentiation and increases susceptibility to wound- and carcinogen-induced tumorigenesis.
    Title: Overexpression of transcription factor sp2 inhibits epidermal differentiation and increases susceptibility to wound- and carcinogen-induced tumorigenesis.
  8. mouse Sp2 transcription yields alternatively spliced and sub-genomic mRNAs in a tissue- and cell-type-specific fashion
    Title: Transcription of mouse Sp2 yields alternatively spliced and sub-genomic mRNAs in a tissue- and cell-type-specific fashion.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within circulatory system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription factor Sp2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080964.2 → NP_001074433.1  transcription factor Sp2 isoform 2

    See identical proteins and their annotated locations for NP_001074433.1

    Status: VALIDATED

    Source sequence(s)
    AA267604, AL596384, BC086457, BP765918
    UniProtKB/Swiss-Prot
    Q6A0E1, Q9D2H6
    UniProtKB/TrEMBL
    D1MAF3
    Conserved Domains (3) summary
    sd00017
    Location:529 → 548
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584 → 606
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:570 → 593
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001363225.1 → NP_001350154.1  transcription factor Sp2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK019649, AL596384
    Consensus CDS
    CCDS88237.1
    UniProtKB/TrEMBL
    D1MAF3, Q3UTN3, Q8BNQ4
    Related
    ENSMUSP00000051403.7, ENSMUST00000062652.7
    Conserved Domains (4) summary
    COG5048
    Location:443 → 581
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:524 → 543
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:579 → 601
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:565 → 588
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001363226.1 → NP_001350155.1  transcription factor Sp2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK080877, AL596384
    Consensus CDS
    CCDS88237.1
    UniProtKB/TrEMBL
    D1MAF3, Q3UTN3, Q8BNQ4
    Related
    ENSMUSP00000103249.2, ENSMUST00000107623.8
    Conserved Domains (4) summary
    COG5048
    Location:443 → 581
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:524 → 543
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:579 → 601
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:565 → 588
    zf-H2C2_2; Zinc-finger double domain

  4. NM_030220.4 → NP_084496.2  transcription factor Sp2 isoform 1

    See identical proteins and their annotated locations for NP_084496.2

    Status: VALIDATED

    Source sequence(s)
    AA267604, AK078246, AL596384, BB848633, BC086457, BP765918
    Consensus CDS
    CCDS36291.1
    UniProtKB/TrEMBL
    Q3UTN3, Q8C5J0
    Related
    ENSMUSP00000103250.3, ENSMUST00000107624.8
    Conserved Domains (3) summary
    sd00017
    Location:530 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:585 → 607
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:571 → 594
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    96844158..96873785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534518.5 → XP_006534581.1  transcription factor Sp2 isoform X1

    See identical proteins and their annotated locations for XP_006534581.1

    UniProtKB/TrEMBL
    D1MAF3, Q3UTN3, Q8BNQ4
    Conserved Domains (4) summary
    COG5048
    Location:443 → 581
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:524 → 543
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:579 → 601
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:565 → 588
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006534519.4 → XP_006534582.1  transcription factor Sp2 isoform X1

    See identical proteins and their annotated locations for XP_006534582.1

    UniProtKB/TrEMBL
    D1MAF3, Q3UTN3, Q8BNQ4
    Conserved Domains (4) summary
    COG5048
    Location:443 → 581
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:524 → 543
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:579 → 601
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:565 → 588
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2H6.2 GenPept UniProtKB/Swiss-Prot:Q9D2H6

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