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Asb15 ankyrin repeat and SOCS box-containing 15 [ Mus musculus (house mouse) ]

Gene ID: 78910, updated on 21-Apr-2024

Summary

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Official Symbol
Asb15provided by MGI
Official Full Name
ankyrin repeat and SOCS box-containing 15provided by MGI
Primary source
MGI:MGI:1926160
See related
Ensembl:ENSMUSG00000029685 AllianceGenome:MGI:1926160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asb-15; 4930400E23Rik
Summary
Predicted to be involved in intracellular signal transduction. Is expressed in genitourinary system; quadriceps femoris muscle; thoracic segment skeleton; and tongue. Orthologous to human ASB15 (ankyrin repeat and SOCS box containing 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 14.4), testis adult (RPKM 4.4) and 2 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 A3.1; 6 11.28 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (24528143..24573163)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (24528144..24573164)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene IQ motif and ubiquitin domain containing Neighboring gene STARR-positive B cell enhancer mm9_chr6:24477506-24477807 Neighboring gene STARR-positive B cell enhancer ABC_E2778 Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 Neighboring gene leiomodin 2 (cardiac) Neighboring gene WASP like actin nucleation promoting factor Neighboring gene STARR-seq mESC enhancer starr_15356

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ankyrin repeat and SOCS box protein 15 regulates protein synthesis in skeletal muscle. McDaneld TG, et al. Am J Physiol Regul Integr Comp Physiol, 2006 Jun. PMID 16424087
  2. Ankyrin repeat and suppressor of cytokine signaling (SOCS) box-containing protein (ASB) 15 alters differentiation of mouse C2C12 myoblasts and phosphorylation of mitogen-activated protein kinase and Akt. McDaneld TG, et al. J Anim Sci, 2008 Nov. PMID 18641171
  3. Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Lefebvre J, et al. Kidney Int, 2015 Aug. PMID 25993318
  4. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535
  5. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ASB15 has a role in early myoblast differentiation and that its effects may be mediated in part by the PI3K/Akt signal transduction pathway
    Title: Ankyrin repeat and suppressor of cytokine signaling (SOCS) box-containing protein (ASB) 15 alters differentiation of mouse C2C12 myoblasts and phosphorylation of mitogen-activated protein kinase and Akt.
  2. Results suggest ASB15 participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells.
    Title: Ankyrin repeat and SOCS box protein 15 regulates protein synthesis in skeletal muscle.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 15
Names
ankyrin repeat and SOCS box-containing protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080847.3 → NP_543123.2  ankyrin repeat and SOCS box protein 15

    See identical proteins and their annotated locations for NP_543123.2

    Status: VALIDATED

    Source sequence(s)
    AK019556, AK029759, AK079418, AK142748
    Consensus CDS
    CCDS19943.1
    UniProtKB/Swiss-Prot
    Q8CDP8, Q8VHS6
    UniProtKB/TrEMBL
    Q8C565
    Related
    ENSMUSP00000031696.4, ENSMUST00000031696.10
    Conserved Domains (5) summary
    PHA02875
    Location:99 → 271
    PHA02875; ankyrin repeat protein; Provisional
    sd00045
    Location:178 → 207
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:47 → 141
    Ank_2; Ankyrin repeats (3 copies)
    cl02533
    Location:532 → 583
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    cl39094
    Location:211 → 440
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    24528143..24573163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241089.3 → XP_011239391.1  ankyrin repeat and SOCS box protein 15 isoform X4

    See identical proteins and their annotated locations for XP_011239391.1

    UniProtKB/Swiss-Prot
    Q8CDP8, Q8VHS6
    UniProtKB/TrEMBL
    Q8C565
    Conserved Domains (5) summary
    PHA02875
    Location:99 → 271
    PHA02875; ankyrin repeat protein; Provisional
    sd00045
    Location:178 → 207
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:47 → 141
    Ank_2; Ankyrin repeats (3 copies)
    cl02533
    Location:532 → 583
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    cl39094
    Location:211 → 440
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_036152406.1 → XP_036008299.1  ankyrin repeat and SOCS box protein 15 isoform X1

    UniProtKB/TrEMBL
    Q8C565
    Conserved Domains (4) summary
    PHA02875
    Location:121 → 293
    PHA02875; ankyrin repeat protein; Provisional
    sd00045
    Location:200 → 229
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:269 → 358
    Ank_2; Ankyrin repeats (3 copies)
    cl02533
    Location:554 → 605
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  3. XM_006505206.4 → XP_006505269.1  ankyrin repeat and SOCS box protein 15 isoform X3

    UniProtKB/TrEMBL
    Q8C565
    Conserved Domains (5) summary
    PHA02875
    Location:116 → 288
    PHA02875; ankyrin repeat protein; Provisional
    sd00045
    Location:195 → 224
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:64 → 158
    Ank_2; Ankyrin repeats (3 copies)
    cl02533
    Location:549 → 600
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    cl39094
    Location:228 → 457
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_036152407.1 → XP_036008300.1  ankyrin repeat and SOCS box protein 15 isoform X2

    UniProtKB/TrEMBL
    Q8C565
    Conserved Domains (4) summary
    PHA02875
    Location:120 → 292
    PHA02875; ankyrin repeat protein; Provisional
    sd00045
    Location:199 → 228
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:268 → 357
    Ank_2; Ankyrin repeats (3 copies)
    cl02533
    Location:553 → 604
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VHS6.2 GenPept UniProtKB/Swiss-Prot:Q8VHS6

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