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Wrnip1 Werner helicase interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 78903, updated on 5-Mar-2024

Summary

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Official Symbol
Wrnip1provided by MGI
Official Full Name
Werner helicase interacting protein 1provided by MGI
Primary source
MGI:MGI:1926153
See related
Ensembl:ENSMUSG00000021400 AllianceGenome:MGI:1926153
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
WHIP; Wrnip; 4833444L21Rik
Summary
Predicted to enable several functions, including ATP hydrolysis activity; identical protein binding activity; and single-stranded DNA helicase activity. Predicted to be involved in cellular macromolecule biosynthetic process and regulation of DNA metabolic process. Predicted to act upstream of or within DNA repair; DNA replication; and innate immune response. Located in nucleus. Is expressed in several structures, including alimentary system; cranial ganglion; cranium; limb; and naris. Orthologous to human WRNIP1 (WRN helicase interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 30.0), adrenal adult (RPKM 23.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A3.2; 13 13.74 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (32986013..33006593)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (32802030..32822610)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34101 Neighboring gene predicted gene, 40876 Neighboring gene myosin light chain kinase family, member 4 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner. Crosetto N, et al. J Biol Chem, 2008 Dec 12. PMID 18842586, Free PMC Article
  2. Analyses of the interaction of WRNIP1 with Werner syndrome protein (WRN) in vitro and in the cell. Kawabe Y, et al. DNA Repair (Amst), 2006 Jul 13. PMID 16769258
  3. A novel protein interacts with the Werner's syndrome gene product physically and functionally. Kawabe Yi, et al. J Biol Chem, 2001 Jun 8. PMID 11301316
  4. RNF166 plays a dual role for Lys63-linked ubiquitination and sumoylation of its target proteins. Hwang IY, et al. J Neural Transm (Vienna), 2022 Jun. PMID 34837535
  5. Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse. Kaiserman D, et al. Genomics, 2002 Mar. PMID 11863365

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA synthesis involved in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA synthesis involved in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated DNA replication initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATPase WRNIP1
Names
Werner helicasae interacting protein 1
Werner syndrome homolog interacting protein
werner helicase-interacting protein 1
NP_084491.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030215.3 → NP_084491.3  ATPase WRNIP1

    See identical proteins and their annotated locations for NP_084491.3

    Status: VALIDATED

    Source sequence(s)
    AK041886, AK167570, AV237237
    Consensus CDS
    CCDS26427.1
    UniProtKB/Swiss-Prot
    Q3TCT7, Q6PDF0, Q8BUW5, Q8BWP6, Q8BY55, Q91XU0, Q921W3, Q9EQL3
    Related
    ENSMUSP00000021832.7, ENSMUST00000021832.7
    Conserved Domains (5) summary
    cd00009
    Location:235 → 371
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    smart00734
    Location:17 → 40
    ZnF_Rad18; Rad18-like CCHC zinc finger
    PRK13342
    Location:221 → 656
    PRK13342; recombination factor protein RarA; Reviewed
    pfam12002
    Location:507 → 656
    MgsA_C; MgsA AAA+ ATPase C terminal
    pfam16193
    Location:417 → 506
    AAA_assoc_2; AAA C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    32986013..33006593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91XU0.2 GenPept UniProtKB/Swiss-Prot:Q91XU0

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