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Pus7l pseudouridylate synthase 7-like [ Mus musculus (house mouse) ]

Gene ID: 78895, updated on 11-Apr-2024

Summary

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Official Symbol
Pus7lprovided by MGI
Official Full Name
pseudouridylate synthase 7-likeprovided by MGI
Primary source
MGI:MGI:1926145
See related
Ensembl:ENSMUSG00000033356 AllianceGenome:MGI:1926145
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3000003F02Rik
Summary
Predicted to enable pseudouridine synthase activity. Predicted to be involved in pseudouridine synthesis. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; forelimb bud; heart ventricle; lower jaw incisor; and lung. Orthologous to human PUS7L (pseudouridine synthase 7 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 2.8), CNS E11.5 (RPKM 2.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pus7l in Genome Data Viewer
Location:
15 E3; 15 48.52 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (94420521..94441397, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (94522640..94543534, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D630010B17 gene Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 20 Neighboring gene STARR-seq mESC enhancer starr_39547 Neighboring gene STARR-positive B cell enhancer mm9_chr15:94351032-94351333 Neighboring gene STARR-positive B cell enhancer ABC_E3153 Neighboring gene STARR-seq mESC enhancer starr_39549 Neighboring gene interleukin-1 receptor-associated kinase 4 Neighboring gene STARR-seq mESC enhancer starr_39550 Neighboring gene STARR-positive B cell enhancer ABC_E7408 Neighboring gene twinfilin actin binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
  2. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables pseudouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pseudouridine synthase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA modification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA pseudouridine synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pseudouridylate synthase PUS7L
Names
pseudouridylate synthase 7 homolog-like protein
NP_766025.1
XP_006521607.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172437.3 → NP_766025.1  pseudouridylate synthase PUS7L

    See identical proteins and their annotated locations for NP_766025.1

    Status: VALIDATED

    Source sequence(s)
    AK029027, AV296268, BY780892
    Consensus CDS
    CCDS27771.1
    UniProtKB/Swiss-Prot
    Q6NY03, Q8C9X5, Q8CE46
    Related
    ENSMUSP00000044075.4, ENSMUST00000049151.4
    Conserved Domains (3) summary
    cd02576
    Location:302 → 698
    PseudoU_synth_ScPUS7; Pseudouridine synthase, TruD family
    pfam15554
    Location:50 → 170
    FSIP1; FSIP1 family
    cl00130
    Location:22 → 46
    PseudoU_synth; Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    94420521..94441397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521544.5 → XP_006521607.1  pseudouridylate synthase PUS7L isoform X1

    Conserved Domains (1) summary
    cd02576
    Location:155 → 551
    PseudoU_synth_ScPUS7; Pseudouridine synthase, TruD family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CE46.1 GenPept UniProtKB/Swiss-Prot:Q8CE46

Gene LinkOut

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