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Ftx Ftx transcript, Xist regulator, non-protein coding [ Mus musculus (house mouse) ]

Gene ID: 78878, updated on 11-Apr-2024

Summary

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Official Symbol
Ftxprovided by MGI
Official Full Name
Ftx transcript, Xist regulator, non-protein codingprovided by MGI
Primary source
MGI:MGI:1926128
See related
Ensembl:ENSMUSG00000086370 AllianceGenome:MGI:1926128
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Thcytx; NCRNA00182; B230206F22Rik
Summary
Acts upstream of or within chromatin organization; regulation of DNA methylation; and regulation of dosage compensation by inactivation of X chromosome. Is expressed in early conceptus. Orthologous to human FTX (FTX transcript, XIST regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 7.9), cortex adult (RPKM 6.7) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X D; X 46.21 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (102604516..102667360, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (103560910..103623754, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene estrogen receptor-binding fragment-associated gene 9 pseudogene Neighboring gene predicted gene, 53177 Neighboring gene STARR-seq mESC enhancer starr_47698 Neighboring gene microRNA 374b Neighboring gene microRNA 374c Neighboring gene microRNA 421 Neighboring gene STARR-seq mESC enhancer starr_47699 Neighboring gene predicted gene 9159 Neighboring gene STARR-positive B cell enhancer ABC_E5733 Neighboring gene zinc finger, CCHC domain containing 13 Neighboring gene predicted gene 53059 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype. Hosoi Y, et al. Nat Commun, 2018 Sep 20. PMID 30237402, Free PMC Article
  2. The Ftx Noncoding Locus Controls X Chromosome Inactivation Independently of Its RNA Products. Furlan G, et al. Mol Cell, 2018 May 3. PMID 29706539
  3. Parental-to-embryo switch of chromosome organization in early embryogenesis. Collombet S, et al. Nature, 2020 Apr. PMID 32238933
  4. Long Noncoding RNA FTX Reduces Hypertrophy of Neonatal Mouse Cardiac Myocytes and Regulates the PTEN/PI3K/Akt Signaling Pathway by Sponging MicroRNA-22. Yang X, et al. Med Sci Monit, 2019 Dec 16. PMID 31840653, Free PMC Article
  5. The lncRNA Ftx/miR-382-5p/Nrg1 axis improves the inflammation response of microglia and spinal cord injury repair. Xiang W, et al. Neurochem Int, 2021 Feb. PMID 33359189

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The lncRNA Ftx/miR-382-5p/Nrg1 axis improves the inflammation response of microglia and spinal cord injury repair.
    Title: The lncRNA Ftx/miR-382-5p/Nrg1 axis improves the inflammation response of microglia and spinal cord injury repair.
  2. The mechanism of action of lnc-FTX in neonatal mouse cardiac myocytes was through suppression of the PI3K/Akt signaling pathway by promoting the release of PTEN by sponging miRNA-22.
    Title: Long Noncoding RNA FTX Reduces Hypertrophy of Neonatal Mouse Cardiac Myocytes and Regulates the PTEN/PI3K/Akt Signaling Pathway by Sponging MicroRNA-22.
  3. loss-of-Ftx lncRNA abolishes gene silencing on the inactive X chromosome, leading to a female microphthalmia-like phenotype.
    Title: Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype.
  4. Ftx is a positive regulator of Xist and lead us to propose that Ftx is a novel ncRNA involved in XCI.
    Title: Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Other Names

  • thrombocytosis, familial X-linked

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression via chromosomal CpG island demethylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within random inactivation of X chromosome IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within random inactivation of X chromosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_028380.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AA189299, AK035525, BC076616, BP758350
    Related
    ENSMUST00000156211.8

  2. NR_028381.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon and uses a distinct 3' splice pattern, compared to variant 1.
    Source sequence(s)
    AK035525
    Related
    ENSMUST00000130063.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    102604516..102667360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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