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Zfp623 zinc finger protein 623 [ Mus musculus (house mouse) ]

Gene ID: 78834, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp623provided by MGI
Official Full Name
zinc finger protein 623provided by MGI
Primary source
MGI:MGI:1926084
See related
Ensembl:ENSMUSG00000050846 AllianceGenome:MGI:1926084
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610029D06Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and retina nuclear layer. Orthologous to human ZNF623 (zinc finger protein 623). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 6.8), whole brain E14.5 (RPKM 6.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D3; 15 35.12 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75812798..75821251)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75940949..75949402)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene pyrroline-5-carboxylate reductase 3 Neighboring gene GDP-L-fucose synthase Neighboring gene STARR-seq mESC enhancer starr_39034 Neighboring gene predicted gene, 53898 Neighboring gene eukaryotic translation initiation factor 2, subunit 3, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC101961

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 623
Names
zinc finger CCCH type domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030199.3 → NP_084475.1  zinc finger protein 623

    See identical proteins and their annotated locations for NP_084475.1

    Status: PROVISIONAL

    Source sequence(s)
    AK046806
    Consensus CDS
    CCDS27556.1
    UniProtKB/TrEMBL
    Q9CY99
    Related
    ENSMUSP00000036049.7, ENSMUST00000037260.8
    Conserved Domains (5) summary
    COG5048
    Location:173 → 322
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:261 → 281
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:93 → 113
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:315 → 337
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:385 → 410
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    75812798..75821251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521543.2 → XP_006521606.1  zinc finger protein 623 isoform X1

    See identical proteins and their annotated locations for XP_006521606.1

    UniProtKB/TrEMBL
    Q9CY99
    Conserved Domains (5) summary
    COG5048
    Location:173 → 322
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:261 → 281
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:93 → 113
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:315 → 337
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:385 → 410
    zf-H2C2_2; Zinc-finger double domain

  2. XM_030248823.2 → XP_030104683.1  zinc finger protein 623 isoform X1

    UniProtKB/TrEMBL
    Q9CY99
    Conserved Domains (5) summary
    COG5048
    Location:173 → 322
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:261 → 281
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:93 → 113
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:315 → 337
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:385 → 410
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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