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Cacul1 CDK2 associated, cullin domain 1 [ Mus musculus (house mouse) ]

Gene ID: 78832, updated on 5-Mar-2024

Summary

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Official Symbol
Cacul1provided by MGI
Official Full Name
CDK2 associated, cullin domain 1provided by MGI
Primary source
MGI:MGI:1926082
See related
Ensembl:ENSMUSG00000033417 AllianceGenome:MGI:1926082
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700078E11Rik; 2810417M16Rik; 9830127L17Rik; D130033C15Rik
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in G1/S transition of mitotic cell cycle; positive regulation of cell population proliferation; and positive regulation of protein kinase activity. Orthologous to human CACUL1 (CDK2 associated cullin domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 11.0), placenta adult (RPKM 7.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 D3; 19 56.52 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (60513143..60569420, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (60524696..60581023, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34300 Neighboring gene prolactin releasing hormone receptor Neighboring gene predicted gene, 41884 Neighboring gene STARR-seq mESC enhancer starr_46598 Neighboring gene STARR-positive B cell enhancer ABC_E3256 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60684594-60684894 Neighboring gene STARR-seq mESC enhancer starr_46599 Neighboring gene predicted gene, 46652 Neighboring gene predicted gene, 34459 Neighboring gene predicted gene, 34406

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2. Kigoshi Y, et al. Sci Rep, 2015 Aug 4. PMID 26238671, Free PMC Article
  2. CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis. Jang MJ, et al. Cell Death Dis, 2017 Dec 11. PMID 29233982, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARgamma and inhibit adipogenesis.
    Title: CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis.
  2. Cacul1 regulates the antioxidant response by stabilizing Nrf2.
    Title: CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CDK2-associated and cullin domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172096.2 → NP_001165567.1  CDK2-associated and cullin domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC108409
    Consensus CDS
    CCDS50484.1
    UniProtKB/TrEMBL
    E9PV69, Q921D1
    Related
    ENSMUSP00000127014.2, ENSMUST00000166712.9
    Conserved Domains (1) summary
    pfam00888
    Location:146 → 278
    Cullin; Cullin family

  2. NM_001172097.2 → NP_001165568.1  CDK2-associated and cullin domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001165568.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the coding region that result in a frameshift, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC108409
    Consensus CDS
    CCDS50483.1
    UniProtKB/Swiss-Prot
    Q8R0X2
    Related
    ENSMUSP00000107086.4, ENSMUST00000111460.5
    Conserved Domains (1) summary
    pfam00888
    Location:146 → 276
    Cullin; Cullin family

  3. NM_030197.3 → NP_084473.1  CDK2-associated and cullin domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_084473.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC108409
    Consensus CDS
    CCDS38034.1
    UniProtKB/Swiss-Prot
    Q3TE79, Q8R0X2, Q9CY95
    UniProtKB/TrEMBL
    Q921D1
    Related
    ENSMUSP00000080480.8, ENSMUST00000081790.15
    Conserved Domains (1) summary
    pfam00888
    Location:146 → 264
    Cullin; Cullin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    60513143..60569420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527468.5 → XP_006527531.1  CDK2-associated and cullin domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006527531.1

    UniProtKB/TrEMBL
    Q3TAW5
    Conserved Domains (1) summary
    pfam00888
    Location:14 → 138
    Cullin; Cullin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0X2.1 GenPept UniProtKB/Swiss-Prot:Q8R0X2

Gene LinkOut

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