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P2ry10 purinergic receptor P2Y, G-protein coupled 10 [ Mus musculus (house mouse) ]

Gene ID: 78826, updated on 21-Apr-2024

Summary

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Official Symbol
P2ry10provided by MGI
Official Full Name
purinergic receptor P2Y, G-protein coupled 10provided by MGI
Primary source
MGI:MGI:1926076
See related
Ensembl:ENSMUSG00000050921 AllianceGenome:MGI:1926076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P2Y10; Lypsr2; 5830408N17Rik
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in thymus primordium. Orthologous to human P2RY10 (P2Y receptor family member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 15.8), spleen adult (RPKM 5.6) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
X D; X 47.43 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (106132098..106148580)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (107088492..107104974)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene retrotransposon Gag like 3 Neighboring gene lysophosphatidic acid receptor 4 Neighboring gene STARR-seq mESC enhancer starr_47740 Neighboring gene STARR-positive B cell enhancer ABC_E11054 Neighboring gene STARR-positive B cell enhancer ABC_E11686 Neighboring gene purinergic receptor P2Y, G-protein coupled 10B Neighboring gene prohibitin pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Ets factors PU.1 and Spi-B regulate the transcription in vivo of P2Y10, a lymphoid restricted heptahelical receptor. Rao S, et al. J Biol Chem, 1999 Nov 26. PMID 10567398
  2. G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators. Gurusamy M, et al. Nat Commun, 2021 Nov 23. PMID 34815397, Free PMC Article
  3. GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair. Wang X, et al. Immunity, 2021 Jun 8. PMID 34107271
  4. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. Kihara Y, et al. Br J Pharmacol, 2014 Aug. PMID 24602016, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.
    Title: G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (4)  1 citation

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative P2Y purinoceptor 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357810.1 → NP_001344739.1  putative P2Y purinoceptor 10

    Status: VALIDATED

    Source sequence(s)
    AK020001, AL928594, BE687386
    Consensus CDS
    CCDS30346.1
    UniProtKB/Swiss-Prot
    A2ASC0, Q7TMT1, Q8BFU7
    UniProtKB/TrEMBL
    F6SDQ0
    Related
    ENSMUSP00000113507.2, ENSMUST00000118666.8
    Conserved Domains (2) summary
    cd14964
    Location:25 → 49
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 305
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_172435.4 → NP_766023.1  putative P2Y purinoceptor 10

    See identical proteins and their annotated locations for NP_766023.1

    Status: VALIDATED

    Source sequence(s)
    AL928594
    Consensus CDS
    CCDS30346.1
    UniProtKB/Swiss-Prot
    A2ASC0, Q7TMT1, Q8BFU7
    UniProtKB/TrEMBL
    F6SDQ0
    Related
    ENSMUSP00000061296.4, ENSMUST00000053375.4
    Conserved Domains (2) summary
    cd14964
    Location:25 → 49
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 305
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    106132098..106148580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BFU7.1 GenPept UniProtKB/Swiss-Prot:Q8BFU7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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