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Vsig1 V-set and immunoglobulin domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 78789, updated on 21-Apr-2024

Summary

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Official Symbol
Vsig1provided by MGI
Official Full Name
V-set and immunoglobulin domain containing 1provided by MGI
Primary source
MGI:MGI:1926039
See related
Ensembl:ENSMUSG00000031430 AllianceGenome:MGI:1926039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700062D20Rik; 4930405J24Rik
Summary
Acts upstream of or within epithelial cell morphogenesis and maintenance of gastrointestinal epithelium. Located in basolateral plasma membrane. Is expressed in stomach; stomach glandular epithelium; stomach glandular region epithelium; and testis. Orthologous to human VSIG1 (V-set and immunoglobulin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 25.5), testis adult (RPKM 16.6) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
X F1; X 61.62 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (139808357..139840221)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (140907608..140939472)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene testis expressed 13B Neighboring gene ribosomal protein S7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48010 Neighboring gene STARR-positive B cell enhancer ABC_E3263 Neighboring gene STARR-seq mESC enhancer starr_48011 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 Neighboring gene autophagy related 4A, cysteine peptidase Neighboring gene STARR-positive B cell enhancer mm9_chrX:137591358-137591658 Neighboring gene collagen, type IV, alpha 6 Neighboring gene predicted gene, 39539

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. V-Set and Immunoglobulin Domain-Containing 1 (VSIG1), Predominantly Expressed in Testicular Germ Cells, Is Dispensable for Spermatogenesis and Male Fertility in Mice. Jung Y, et al. Animals (Basel), 2021 Apr 7. PMID 33916888, Free PMC Article
  2. Functional Pro-metastatic Heterogeneity Revealed by Spiked-scRNAseq Is Shaped by Cancer Cell Interactions and Restricted by VSIG1. Bernal C, et al. Cell Rep, 2020 Nov 10. PMID 33176137
  3. Impairments to the GH-IGF-I axis in hSOD1G93A mice give insight into possible mechanisms of GH dysregulation in patients with amyotrophic lateral sclerosis. Steyn FJ, et al. Endocrinology, 2012 Aug. PMID 22621959
  4. Extracellular domain of V-set and immunoglobulin domain containing 1 (VSIG1) interacts with sertoli cell membrane protein, while its PDZ-binding motif forms a complex with ZO-1. Kim E, et al. Mol Cells, 2010 Nov. PMID 20957455
  5. Adhesion protein VSIG1 is required for the proper differentiation of glandular gastric epithelia. Oidovsambuu O, et al. PLoS One, 2011. PMID 21991385, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional Pro-metastatic Heterogeneity Revealed by Spiked-scRNAseq Is Shaped by Cancer Cell Interactions and Restricted by VSIG1.
    Title: Functional Pro-metastatic Heterogeneity Revealed by Spiked-scRNAseq Is Shaped by Cancer Cell Interactions and Restricted by VSIG1.
  2. VSIG1 is required for the establishment of glandular versus squamous epithelia in the stomach.
    Title: Adhesion protein VSIG1 is required for the proper differentiation of glandular gastric epithelia.
  3. mouse VSIG1 interacts with Sertoli cells by heterophilic adhesion via its first Ig-like domain
    Title: Extracellular domain of V-set and immunoglobulin domain containing 1 (VSIG1) interacts with sertoli cell membrane protein, while its PDZ-binding motif forms a complex with ZO-1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within epithelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of gastrointestinal epithelium IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within maintenance of gastrointestinal epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
V-set and immunoglobulin domain-containing protein 1
Names
cell surface A33 antigen
glycoprotein A34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359143.1 → NP_001346072.1  V-set and immunoglobulin domain-containing protein 1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AK132956, BC145050
    UniProtKB/Swiss-Prot
    Q9D2J4, Q9D9J0, Q9DA22
    UniProtKB/TrEMBL
    B7ZN70
    Conserved Domains (2) summary
    pfam13927
    Location:180 → 253
    Ig_3; Immunoglobulin domain
    cl11960
    Location:24 → 165
    Ig; Immunoglobulin domain

  2. NM_026103.1 → NP_080379.1  V-set and immunoglobulin domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_080379.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different segment for its 5' UTR and lacks part of the 5' coding region with the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AK006862, AK132956
    UniProtKB/Swiss-Prot
    Q9D2J4
    Conserved Domains (3) summary
    smart00409
    Location:47 → 122
    IG; Immunoglobulin
    cl11960
    Location:1 → 22
    Ig; Immunoglobulin domain
    cl29137
    Location:207 → 252
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)

  3. NM_030181.3 → NP_084457.2  V-set and immunoglobulin domain-containing protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_084457.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. It encodes the longer protein (isoform 1).
    Source sequence(s)
    AK132956
    Consensus CDS
    CCDS30443.1
    UniProtKB/Swiss-Prot
    Q9D2J4, Q9D9J0, Q9DA22
    UniProtKB/TrEMBL
    A0A0B4J1E9
    Related
    ENSMUSP00000033806.5, ENSMUST00000033806.5
    Conserved Domains (3) summary
    cd00096
    Location:159 → 226
    Ig; Immunoglobulin domain
    smart00410
    Location:154 → 229
    IG_like; Immunoglobulin like
    cl11960
    Location:25 → 129
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    139808357..139840221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528631.5 → XP_006528694.1  V-set and immunoglobulin domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006528694.1

    Related
    ENSMUST00000127629.2
    Conserved Domains (3) summary
    smart00409
    Location:47 → 122
    IG; Immunoglobulin
    cl11960
    Location:1 → 22
    Ig; Immunoglobulin domain
    cl29137
    Location:207 → 252
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2J4.1 GenPept UniProtKB/Swiss-Prot:Q9D2J4

Gene LinkOut

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