Zc3hav1 zinc finger CCCH type, antiviral 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zc3hav1provided by MGI
Official Full Name: zinc finger CCCH type, antiviral 1provided by MGI
Primary source: MGI:MGI:1926031
See related: Ensembl:ENSMUSG00000029826 AllianceGenome:MGI:1926031
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZAP; ARTD13; PARP13; D6Bwg1452e; 1200014N16Rik; 2900058M19Rik; 9130009D18Rik; 9830115L13Rik
Summary: Predicted to enable DEAD/H-box RNA helicase binding activity; RNA binding activity; and identical protein binding activity. Acts upstream of or within cellular response to exogenous dsRNA and positive regulation of type I interferon production. Located in late endosome; lysosome; and nucleus. Is expressed in early conceptus; inner cell mass; liver lobe; oocyte; and thymus primordium. Orthologous to human ZC3HAV1 (zinc finger CCCH-type containing, antiviral 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 12.8), spleen adult (RPKM 10.0) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B1; 6 17.72 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (38282221..38332859, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (38305286..38355352, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular Mechanism of RNA Recognition by Zinc-Finger Antiviral Protein.
Title: Molecular Mechanism of RNA Recognition by Zinc-Finger Antiviral Protein.
S-farnesylation is crucial for targeting the long-isoform of ZAP to endolysosomes and enhancing the antiviral activity of this immune effector.
Title: Prenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long-isoform.
ZAP inhibits M2 expression and regulates the maintenance of MHV-68 latency
Title: Zinc finger antiviral protein inhibits murine gammaherpesvirus 68 M2 expression and regulates viral latency in cultured cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

N28141 (e-PCR)
- UniSTS:125502

RH125060 (e-PCR)
- UniSTS:161882

D6Bwg1452e (e-PCR), detects polymorphism
- UniSTS:142576

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DEAD/H-box RNA helicase binding	ISO Inferred from Sequence Orthology more info	PubMed
enables NAD+ ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to exogenous dsRNA	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to virus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of RIG-I signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of RIG-I signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of type I interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in response to virus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to virus	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger CCCH-type antiviral protein 1

Names: ADP-ribosyltransferase diphtheria toxin-like 13; inactive Poly [ADP-ribose] polymerase 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347122.1 → NP_001334051.1 zinc finger CCCH-type antiviral protein 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).

Source sequence(s)

AC125530

Consensus CDS

CCDS85033.1

UniProtKB/TrEMBL

D3Z5I1

Related

ENSMUSP00000110550.2, ENSMUST00000114900.8
NM_028421.1 → NP_082697.1 zinc finger CCCH-type antiviral protein 1 isoform 1

See identical proteins and their annotated locations for NP_082697.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform 1 which is shorter and has a distinct C-terminus, compared to isoform 3.

Source sequence(s)

AC125530

Consensus CDS

CCDS80522.1

UniProtKB/Swiss-Prot

Q3UPF5, Q9CTU4, Q9DBS7

Related

ENSMUSP00000144312.2, ENSMUST00000143702.5

Conserved Domains (2) summary

pfam02825
Location:696 → 772

WWE; WWE domain

cl00283
Location:876 → 908

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
NM_028864.2 → NP_083140.1 zinc finger CCCH-type antiviral protein 1 isoform 2

See identical proteins and their annotated locations for NP_083140.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 3.

Source sequence(s)

AK004770

Consensus CDS

CCDS20012.1

UniProtKB/TrEMBL

G3X9X5

Related

ENSMUSP00000031850.5, ENSMUST00000031850.10

Conserved Domains (1) summary

pfam02825
Location:696 → 772

WWE; WWE domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

38282221..38332859 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506780.5 → XP_006506843.1 zinc finger CCCH-type antiviral protein 1 isoform X1

Conserved Domains (4) summary

cd01439
Location:760 → 868

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

pfam02825
Location:581 → 656

WWE; WWE domain

pfam18606
Location:5 → 66

HTH_53; Zap helix turn helix N-terminal domain

pfam18633
Location:143 → 170

zf-CCCH_8; Zinc-finger antiviral protein (ZAP) zinc finger domain 3