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Tepsin TEPSIN, adaptor related protein complex 4 accessory protein [ Mus musculus (house mouse) ]

Gene ID: 78777, updated on 5-Mar-2024

Summary

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Official Symbol
Tepsinprovided by MGI
Official Full Name
TEPSIN, adaptor related protein complex 4 accessory proteinprovided by MGI
Primary source
MGI:MGI:1926027
See related
Ensembl:ENSMUSG00000025377 AllianceGenome:MGI:1926027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Enthd2; 2410002I01Rik
Summary
Predicted to be located in Golgi apparatus; coated vesicle membrane; and nucleus. Predicted to be extrinsic component of organelle membrane. Predicted to be part of AP-4 adaptor complex. Predicted to be active in trans-Golgi network membrane. Orthologous to human TEPSIN (TEPSIN adaptor related protein complex 4 accessory protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 30.8), small intestine adult (RPKM 19.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 83.96 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119981348..119989675, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120090522..120098880, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene apoptosis-associated tyrosine kinase Neighboring gene microRNA 3065 Neighboring gene microRNA 338 Neighboring gene centrosomal protein 131 Neighboring gene STARR-positive B cell enhancer ABC_E4021 Neighboring gene STARR-positive B cell enhancer ABC_E206 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 8 Neighboring gene solute carrier family 38, member 10 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120011125-120011308 Neighboring gene STARR-positive B cell enhancer ABC_E382 Neighboring gene predicted gene 11769

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Horiuchi K, et al. Cell Rep, 2018 Apr 3. PMID 29617656
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of AP-4 adaptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in coated vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in extrinsic component of organelle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
AP-4 complex accessory subunit tepsin
Names
ENTH domain containing 2
ENTH domain-containing protein 2
protein C17orf56 homolog
tetra-epsin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183137.2 → NP_898960.2  AP-4 complex accessory subunit tepsin

    See identical proteins and their annotated locations for NP_898960.2

    Status: VALIDATED

    Source sequence(s)
    AK019105, BB868415, BC049110, BC094318, BY084429, BY665064
    Consensus CDS
    CCDS36387.1
    UniProtKB/Swiss-Prot
    Q3U3N6, Q8C1H2
    UniProtKB/TrEMBL
    B1AXJ1, B2RPS6
    Related
    ENSMUSP00000091428.6, ENSMUST00000093901.12
    Conserved Domains (1) summary
    cd03572
    Location:15 → 134
    ENTH_epsin_related; ENTH domain, Epsin Related family; composed of hypothetical proteins containing an ENTH-like domain. The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    119981348..119989675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249318.4 → XP_011247620.1  AP-4 complex accessory subunit tepsin isoform X3

  2. XM_006534514.5 → XP_006534577.1  AP-4 complex accessory subunit tepsin isoform X2

    See identical proteins and their annotated locations for XP_006534577.1

    UniProtKB/TrEMBL
    B1AXJ1
    Conserved Domains (1) summary
    cl02544
    Location:26 → 58
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily

  3. XM_006534512.5 → XP_006534575.1  AP-4 complex accessory subunit tepsin isoform X1

    UniProtKB/TrEMBL
    B1AXJ1
    Conserved Domains (2) summary
    PHA03379
    Location:380 → 548
    PHA03379; EBNA-3A; Provisional
    cd03572
    Location:24 → 117
    ENTH_like_Tepsin; Epsin N-Terminal Homology (ENTH)-like domain of AP-4 complex accessory subunit Tepsin and similar domains

  4. XM_006534513.3 → XP_006534576.1  AP-4 complex accessory subunit tepsin isoform X2

    See identical proteins and their annotated locations for XP_006534576.1

    UniProtKB/TrEMBL
    B1AXJ1
    Conserved Domains (1) summary
    cl02544
    Location:26 → 58
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U3N6.1 GenPept UniProtKB/Swiss-Prot:Q3U3N6

Gene LinkOut

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