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Cfap61 cilia and flagella associated protein 61 [ Mus musculus (house mouse) ]

Gene ID: 78774, updated on 28-Apr-2024

Summary

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Official Symbol
Cfap61provided by MGI
Official Full Name
cilia and flagella associated protein 61provided by MGI
Primary source
MGI:MGI:1926024
See related
Ensembl:ENSMUSG00000037143 AllianceGenome:MGI:1926024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930529M08Rik
Summary
Predicted to be located in cell projection; cytoplasm; and cytoskeleton. Orthologous to human CFAP61 (cilia and flagella associated protein 61). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 5.7) and lung adult (RPKM 0.3) See more
Orthologs
human all
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Genomic context

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Location:
2 G1; 2 71.28 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (145776677..146056955)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (145934757..146215035)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05933 Neighboring gene STARR-positive B cell enhancer ABC_E8796 Neighboring gene STARR-positive B cell enhancer ABC_E5996 Neighboring gene STARR-positive B cell enhancer mm9_chr2:145783203-145783504 Neighboring gene N(alpha)-acetyltransferase 20, NatB catalytic subunit Neighboring gene crooked neck pre-mRNA splicing factor 1 Neighboring gene STARR-seq mESC enhancer starr_05934 Neighboring gene STARR-seq mESC enhancer starr_05935 Neighboring gene STARR-seq mESC enhancer starr_05936 Neighboring gene predicted gene, 34629 Neighboring gene RIKEN cDNA A930019D19 gene Neighboring gene Ral GTPase activating protein, alpha subunit 2 (catalytic) Neighboring gene insulinoma-associated 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Absence of murine CFAP61 causes male infertility due to multiple morphological abnormalities of the flagella. Huang T, et al. Sci Bull (Beijing), 2020 May 30. PMID 36659204
  2. Biallelic CFAP61 variants cause male infertility in humans and mice with severe oligoasthenoteratozoospermia. Hu T, et al. J Med Genet, 2023 Feb. PMID 35387802
  3. CFAP61 is required for sperm flagellum formation and male fertility in human and mouse. Liu S, et al. Development, 2021 Dec 1. PMID 34792097
  4. Identification of positional candidate genes for body weight and adiposity in subcongenic mice. Chiu S, et al. Physiol Genomics, 2007 Sep 19. PMID 17536020
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Biallelic CFAP61 variants cause male infertility in humans and mice with severe oligoasthenoteratozoospermia.
    Title: Biallelic CFAP61 variants cause male infertility in humans and mice with severe oligoasthenoteratozoospermia.
  2. CFAP61 is required for sperm flagellum formation and male fertility in human and mouse.
    Title: CFAP61 is required for sperm flagellum formation and male fertility in human and mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC58680, MGC129508, MGC129509

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of sperm flagellum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sperm flagellum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm flagellum assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatid nucleus elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of radial spoke ISA
Inferred from Sequence Alignment
more info
 PubMed 
part_of radial spoke stalk IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cilia- and flagella-associated protein 61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369121.1 → NP_001356050.1  cilia- and flagella-associated protein 61 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672100, AL732467, AL935056
    Consensus CDS
    CCDS89562.1
    UniProtKB/Swiss-Prot
    Q3KNX7, Q8CEL2, Q8R1E0
    UniProtKB/TrEMBL
    A8Y5L4, B2FDI8
    Related
    ENSMUSP00000118411.2, ENSMUST00000133433.8
    Conserved Domains (2) summary
    COG1251
    Location:660 → 779
    NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]
    pfam16092
    Location:15 → 268
    DUF4821; Domain of unknown function (DUF4821)

  2. NM_175280.3 → NP_780489.2  cilia- and flagella-associated protein 61 isoform 2

    See identical proteins and their annotated locations for NP_780489.2

    Status: VALIDATED

    Source sequence(s)
    AK038772
    Consensus CDS
    CCDS50736.1
    UniProtKB/TrEMBL
    B7ZCD6
    Related
    ENSMUSP00000112099.2, ENSMUST00000116398.8
    Conserved Domains (1) summary
    pfam16092
    Location:15 → 237
    DUF4821; Domain of unknown function (DUF4821)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    145776677..146056955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252249.1 → XP_030108109.1  cilia- and flagella-associated protein 61 isoform X1

    UniProtKB/Swiss-Prot
    Q3KNX7, Q8CEL2, Q8R1E0
    Conserved Domains (2) summary
    COG1251
    Location:660 → 779
    NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]
    pfam16092
    Location:17 → 268
    DUF4821; Domain of unknown function (DUF4821)

  2. XM_030252246.2 → XP_030108106.1  cilia- and flagella-associated protein 61 isoform X2

    UniProtKB/Swiss-Prot
    Q3KNX7, Q8CEL2, Q8R1E0
    Conserved Domains (2) summary
    COG1251
    Location:658 → 777
    NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]
    pfam16092
    Location:17 → 268
    DUF4821; Domain of unknown function (DUF4821)

  3. XM_036162725.1 → XP_036018618.1  cilia- and flagella-associated protein 61 isoform X7

    Conserved Domains (1) summary
    pfam16092
    Location:17 → 268
    DUF4821; Domain of unknown function (DUF4821)

  4. XM_030252245.1 → XP_030108105.1  cilia- and flagella-associated protein 61 isoform X1

    UniProtKB/Swiss-Prot
    Q3KNX7, Q8CEL2, Q8R1E0
    Conserved Domains (2) summary
    COG1251
    Location:660 → 779
    NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]
    pfam16092
    Location:17 → 268
    DUF4821; Domain of unknown function (DUF4821)

  5. XM_036162724.1 → XP_036018617.1  cilia- and flagella-associated protein 61 isoform X6

    Conserved Domains (2) summary
    COG1251
    Location:419 → 538
    NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]
    pfam16092
    Location:1 → 27
    DUF4821; Domain of unknown function (DUF4821)

  6. XM_030252247.1 → XP_030108107.1  cilia- and flagella-associated protein 61 isoform X3

    UniProtKB/Swiss-Prot
    Q3KNX7, Q8CEL2, Q8R1E0
    Conserved Domains (2) summary
    COG1251
    Location:596 → 715
    NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]
    pfam16092
    Location:2 → 204
    DUF4821; Domain of unknown function (DUF4821)

  7. XM_030252250.1 → XP_030108110.1  cilia- and flagella-associated protein 61 isoform X5

    UniProtKB/Swiss-Prot
    Q3KNX7, Q8CEL2, Q8R1E0
    Conserved Domains (2) summary
    COG1251
    Location:464 → 583
    NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]
    pfam16092
    Location:1 → 72
    DUF4821; Domain of unknown function (DUF4821)

  8. XM_030252248.2 → XP_030108108.1  cilia- and flagella-associated protein 61 isoform X4

    UniProtKB/Swiss-Prot
    Q3KNX7, Q8CEL2, Q8R1E0
    Conserved Domains (2) summary
    COG1251
    Location:556 → 675
    NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]
    pfam16092
    Location:1 → 164
    DUF4821; Domain of unknown function (DUF4821)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CEL2.2 GenPept UniProtKB/Swiss-Prot:Q8CEL2

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