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Filip1l filamin A interacting protein 1-like [ Mus musculus (house mouse) ]

Gene ID: 78749, updated on 5-Mar-2024

Summary

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Official Symbol
Filip1lprovided by MGI
Official Full Name
filamin A interacting protein 1-likeprovided by MGI
Primary source
MGI:MGI:1925999
See related
Ensembl:ENSMUSG00000043336 AllianceGenome:MGI:1925999
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Doc1; 4631422O05Rik
Summary
Predicted to be located in cytoplasm; membrane; and nucleus. Is expressed in pectoral girdle and thoracic body wall musculature. Orthologous to human FILIP1L (filamin A interacting protein 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 18.6), limb E14.5 (RPKM 7.5) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C1.1; 16 34.22 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (57173376..57393167)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (57353277..57572804)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41082 Neighboring gene STARR-seq mESC enhancer starr_41083 Neighboring gene transmembrane protein 30C Neighboring gene predicted gene, 26800 Neighboring gene RIKEN cDNA 4921517D16 gene Neighboring gene cms small ribosomal subunit 1 Neighboring gene STARR-seq mESC enhancer starr_41085 Neighboring gene STARR-positive B cell enhancer ABC_E11618 Neighboring gene chaperonin containing Tcp1, subunit 8 (theta) pseudogene Neighboring gene STARR-seq mESC enhancer starr_41086 Neighboring gene STARR-seq mESC enhancer starr_41087 Neighboring gene STARR-positive B cell enhancer ABC_E7469 Neighboring gene STARR-seq mESC enhancer starr_41088 Neighboring gene STARR-positive B cell enhancer ABC_E10913 Neighboring gene predicted gene, 53930 Neighboring gene STARR-positive B cell enhancer ABC_E4181 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:57606921-57607108 Neighboring gene microRNA 1970b Neighboring gene collagen, type VIII, alpha 1 Neighboring gene STARR-positive B cell enhancer mm9_chr16:57669432-57669732 Neighboring gene STARR-seq mESC enhancer starr_41090

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1. Kwon M, et al. Cancer Res, 2021 Nov 1. PMID 34417201, Free PMC Article
  2. Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130). Revert-Ros F, et al. J Biol Chem, 2011 Oct 7. PMID 21832087, Free PMC Article
  3. TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis. Yang Y, et al. EMBO J, 2022 Jul 18. PMID 35670107, Free PMC Article
  4. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Cirilli M, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27746211
  5. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Smoking-associated Downregulation of FILIP1L Enhances Lung Adenocarcinoma Progression Through Mucin Production, Inflammation, and Fibrosis.
    Title: Smoking-associated Downregulation of FILIP1L Enhances Lung Adenocarcinoma Progression Through Mucin Production, Inflammation, and Fibrosis.
  2. FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1.
    Title: FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1.
  3. GPBP directs myofibril formation through interaction with intracellular downstream effector 130-kDa GPBP-interacting protein
    Title: Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
filamin A-interacting protein 1-like
Names
downregulated in ovarian cancer 1-like
protein down-regulated in ovarian cancer 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040397.5 → NP_001035487.2  filamin A-interacting protein 1-like isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC144776, CT025521, CT030226
    Consensus CDS
    CCDS37366.2
    UniProtKB/Swiss-Prot
    B2ZAA3, B3GM33, Q05CK4, Q3UIY5, Q4G0B9, Q6P6L0
    UniProtKB/TrEMBL
    E0CYH7
    Related
    ENSMUSP00000124179.2, ENSMUST00000159816.8
    Conserved Domains (3) summary
    COG0419
    Location:85 → 678
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    TIGR02168
    Location:539 → 842
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam09727
    Location:64 → 246
    CortBP2; Cortactin-binding protein-2

  2. NM_001177871.1 → NP_001171342.1  filamin A-interacting protein 1-like isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC144776, AK019472
    Consensus CDS
    CCDS49877.1
    UniProtKB/TrEMBL
    E0CYM1
    Related
    ENSMUSP00000124069.2, ENSMUST00000159414.2
    Conserved Domains (5) summary
    COG1340
    Location:87 → 360
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    pfam00901
    Location:189 → 302
    Orbi_VP5; Orbivirus outer capsid protein VP5
    pfam06009
    Location:53 → 139
    Laminin_II; Laminin Domain II
    pfam17061
    Location:668 → 890
    PARM; PARM
    cl03075
    Location:380 → 431
    GrpE; nucleotide exchange factor GrpE

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    57173376..57393167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249333.2 → XP_030105193.1  filamin A-interacting protein 1-like isoform X1

    UniProtKB/Swiss-Prot
    B2ZAA3, B3GM33, Q05CK4, Q3UIY5, Q4G0B9, Q6P6L0
    Conserved Domains (3) summary
    COG1196
    Location:138 → 502
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:4 → 220
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam17061
    Location:722 → 944
    PARM
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P6L0.2 GenPept UniProtKB/Swiss-Prot:Q6P6L0

Gene LinkOut

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