U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Plekhj1 pleckstrin homology domain containing, family J member 1 [ Mus musculus (house mouse) ]

Gene ID: 78670, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Plekhj1provided by MGI
Official Full Name
pleckstrin homology domain containing, family J member 1provided by MGI
Primary source
MGI:MGI:1925920
See related
Ensembl:ENSMUSG00000035278 AllianceGenome:MGI:1925920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9530063M10Rik
Summary
Predicted to be involved in endosome organization; receptor recycling; and retrograde transport, endosome to Golgi. Predicted to be active in early endosome; recycling endosome; and trans-Golgi network. Is expressed in brain; gonad; liver; musculature; and spleen. Orthologous to human PLEKHJ1 (pleckstrin homology domain containing J1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 26.2), limb E14.5 (RPKM 24.8) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10 C1; 10 39.72 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80631933..80634404, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80796099..80798626, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8348 Neighboring gene STARR-positive B cell enhancer ABC_E3900 Neighboring gene predicted gene, 53592 Neighboring gene DOT1 like histone lysine methyltransferase Neighboring gene STARR-seq mESC enhancer starr_27297 Neighboring gene VISTA enhancer mm200 Neighboring gene splicing factor 3a, subunit 2 Neighboring gene Amh promoter region Neighboring gene anti-Mullerian hormone

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. An expressed GNRP-like gene shares a bi-directional promoter with SF3A2 (SAP62) immediately upstream of AMH. Dresser DW, et al. Gene, 2001 Oct 17. PMID 11602354
  2. The genes for a spliceosome protein (SAP62) and the anti-Müllerian hormone (AMH) are contiguous. Dresser DW, et al. Hum Mol Genet, 1995 Sep. PMID 8541848
  3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
pleckstrin homology domain-containing family J member 1
Names
PH domain-containing family J member 1
guanine nucleotide releasing protein x

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023900.3 → NP_076389.2  pleckstrin homology domain-containing family J member 1

    See identical proteins and their annotated locations for NP_076389.2

    Status: VALIDATED

    Source sequence(s)
    AC166937
    Consensus CDS
    CCDS48640.1
    UniProtKB/Swiss-Prot
    Q8BQ13, Q9D240, Q9EPF0
    Related
    ENSMUSP00000042334.6, ENSMUST00000036805.7
    Conserved Domains (2) summary
    cd13258
    Location:1 → 112
    PH_PLEKHJ1; Pleckstrin homology domain containing, family J member 1 Pleckstrin homology (PH) domain
    pfam00169
    Location:25 → 108
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80631933..80634404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314166.2 → XP_017169655.1  pleckstrin homology domain-containing family J member 1 isoform X3

    Related
    ENSMUST00000219767.2
    Conserved Domains (1) summary
    cd13258
    Location:1 → 106
    PH_PLEKHJ1; Pleckstrin homology domain containing, family J member 1 Pleckstrin homology (PH) domain

  2. XM_030245395.1 → XP_030101255.1  pleckstrin homology domain-containing family J member 1 isoform X5

    Conserved Domains (1) summary
    cl17171
    Location:1 → 67
    PH-like; Pleckstrin homology-like domain

  3. XM_006514326.3 → XP_006514389.1  pleckstrin homology domain-containing family J member 1 isoform X1

    Conserved Domains (1) summary
    cd13258
    Location:1 → 112
    PH_PLEKHJ1; Pleckstrin homology domain containing, family J member 1 Pleckstrin homology (PH) domain

  4. XM_006514327.4 → XP_006514390.1  pleckstrin homology domain-containing family J member 1 isoform X4

    Conserved Domains (1) summary
    cl17171
    Location:1 → 67
    PH-like; Pleckstrin homology-like domain

  5. XM_017314165.1 → XP_017169654.1  pleckstrin homology domain-containing family J member 1 isoform X2

    Conserved Domains (1) summary
    cd13258
    Location:1 → 106
    PH_PLEKHJ1; Pleckstrin homology domain containing, family J member 1 Pleckstrin homology (PH) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D240.1 GenPept UniProtKB/Swiss-Prot:Q9D240

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous