Brd8 bromodomain containing 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Brd8provided by MGI
Official Full Name: bromodomain containing 8provided by MGI
Primary source: MGI:MGI:1925906
See related: Ensembl:ENSMUSG00000003778 AllianceGenome:MGI:1925906
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SMAP; 2610007E11Rik; 4432404P07Rik
Summary: Predicted to enable nuclear receptor coactivator activity and thyroid hormone receptor binding activity. Predicted to be involved in cellular response to thyroid hormone stimulus; histone acetylation; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within chromatin organization and regulation of growth. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of NuA4 histone acetyltransferase complex and Swr1 complex. Is expressed in early conceptus; ganglia; genitourinary system; heart; and limb mesenchyme. Orthologous to human BRD8 (bromodomain containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 21.2), CNS E14 (RPKM 15.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B1; 18 18.69 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (34731668..34757916, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (34598611..34624863, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

incorporation of the histone variant H2A.Z at the promoter regions of PPARgamma target genes by p400/Brd8 is essential to allow fat cell differentiation
Title: The p400/Brd8 chromatin remodeling complex promotes adipogenesis by incorporating histone variant H2A.Z at PPARγ target genes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nuclear thyroid hormone receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to thyroid hormone stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuA4 histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of Swr1 complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bromodomain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289606.1 → NP_001276535.1 bromodomain-containing protein 8 isoform 2

See identical proteins and their annotated locations for NP_001276535.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.

Source sequence(s)

AK032320, AK161689, AV322131, CD555707

Consensus CDS

CCDS70879.1

UniProtKB/Swiss-Prot

Q8R3B7

Related

ENSMUSP00000095229.4, ENSMUST00000097626.10

Conserved Domains (1) summary

cd05507
Location:709 → 812

Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...
NM_001289607.1 → NP_001276536.1 bromodomain-containing protein 8 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter isoform (3), compared to isoform 1.

Source sequence(s)

AK032320, AK161689, AV322131, CD555707

Consensus CDS

CCDS70880.1

UniProtKB/TrEMBL

D3YZC7

Related

ENSMUSP00000111432.2, ENSMUST00000115766.8

Conserved Domains (1) summary

cd05507
Location:712 → 815

Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...
NM_001361136.1 → NP_001348065.1 bromodomain-containing protein 8 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which is longer and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC074335

Consensus CDS

CCDS89217.1

UniProtKB/TrEMBL

D3YZC8

Related

ENSMUSP00000111431.2, ENSMUST00000115765.2

Conserved Domains (2) summary

cd05507
Location:782 → 885

Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...

cl26464
Location:176 → 356

Atrophin-1; Atrophin-1 family
NM_030147.3 → NP_084423.2 bromodomain-containing protein 8 isoform 1

See identical proteins and their annotated locations for NP_084423.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript.

Source sequence(s)

AK032320, AK161689, AV322131, CD555707

Consensus CDS

CCDS50248.1

UniProtKB/Swiss-Prot

Q3TSZ2, Q8C049, Q8R3B7, Q8R583, Q8VDP0

Related

ENSMUSP00000003876.4, ENSMUST00000003876.10

Conserved Domains (1) summary

cd05507
Location:782 → 885

Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

34731668..34757916 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526358.5 → XP_006526421.1 bromodomain-containing protein 8 isoform X1

Conserved Domains (2) summary

cd05507
Location:712 → 815

Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...

pfam08493
Location:199 → 415

AflR; Aflatoxin regulatory protein