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Bola3 bolA family member 3 [ Mus musculus (house mouse) ]

Gene ID: 78653, updated on 5-Mar-2024

Summary

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Official Symbol
Bola3provided by MGI
Official Full Name
bolA family member 3provided by MGI
Primary source
MGI:MGI:1925903
See related
Ensembl:ENSMUSG00000045160 AllianceGenome:MGI:1925903
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810056O20Rik
Summary
Predicted to be located in cytosol; mitochondrion; and nuclear body. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 2. Orthologous to human BOLA3 (bolA family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 34.5), liver E14.5 (RPKM 31.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 C3; 6 35.94 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83326129..83337118)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83349147..83360136)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4836 Neighboring gene STARR-positive B cell enhancer ABC_E1323 Neighboring gene methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase Neighboring gene STARR-positive B cell enhancer ABC_E6448 Neighboring gene STARR-seq mESC enhancer starr_16463 Neighboring gene MOB kinase activator 1A Neighboring gene tet methylcytosine dioxygenase 3 Neighboring gene microRNA 6374 Neighboring gene STARR-positive B cell enhancer ABC_E4837 Neighboring gene RIKEN cDNA B230319C09 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. Tajima K, et al. Nat Metab, 2019 Sep. PMID 32313871, Free PMC Article
  2. BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension. Yu Q, et al. Circulation, 2019 May 7. PMID 30759996, Free PMC Article
  3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein maturation by [4Fe-4S] cluster transfer IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of iron-sulfur cluster assembly complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bolA-like protein 3
Names
bolA-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363772.1 → NP_001350701.1  bolA-like protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159713, BC049748, CO039842
    Consensus CDS
    CCDS90068.1
    UniProtKB/TrEMBL
    E9Q705
    Related
    ENSMUSP00000113439.2, ENSMUST00000122216.8
    Conserved Domains (1) summary
    cl00386
    Location:23 → 94
    BolA; BolA-like protein

  2. NM_001363773.1 → NP_001350702.1  bolA-like protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159713, CF981442, CO039842
    Consensus CDS
    CCDS90069.1
    UniProtKB/TrEMBL
    E9PX89
    Related
    ENSMUSP00000112582.2, ENSMUST00000120040.8
    Conserved Domains (1) summary
    cl00386
    Location:64 → 135
    BolA; BolA-like protein

  3. NM_175277.5 → NP_780486.1  bolA-like protein 3 isoform 1

    See identical proteins and their annotated locations for NP_780486.1

    Status: VALIDATED

    Source sequence(s)
    AC159713
    Consensus CDS
    CCDS20278.1
    UniProtKB/Swiss-Prot
    Q8CEI1
    UniProtKB/TrEMBL
    Q14A77
    Related
    ENSMUSP00000118348.2, ENSMUST00000136501.2
    Conserved Domains (1) summary
    cl00386
    Location:38 → 109
    BolA; BolA-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    83326129..83337118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152401.1 → XP_036008294.1  bolA-like protein 3 isoform X1

    Conserved Domains (1) summary
    cl00386
    Location:38 → 90
    BolA; BolA-like protein

  2. XM_017321834.1 → XP_017177323.1  bolA-like protein 3 isoform X2

    Conserved Domains (1) summary
    cl00386
    Location:65 → 136
    BolA; BolA-like protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CEI1.1 GenPept UniProtKB/Swiss-Prot:Q8CEI1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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