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Adgra2 adhesion G protein-coupled receptor A2 [ Mus musculus (house mouse) ]

Gene ID: 78560, updated on 11-Apr-2024

Summary

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Official Symbol
Adgra2provided by MGI
Official Full Name
adhesion G protein-coupled receptor A2provided by MGI
Primary source
MGI:MGI:1925810
See related
Ensembl:ENSMUSG00000031486 AllianceGenome:MGI:1925810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tem5; Gpr124; mKIAA1531; 8430414O08Rik; 9530074E10Rik
Summary
Predicted to enable G protein-coupled receptor activity. Involved in several processes, including endothelial cell migration; positive regulation of canonical Wnt signaling pathway; and sprouting angiogenesis. Acts upstream of or within several processes, including negative regulation of vascular endothelial growth factor signaling pathway; positive regulation of endothelial cell migration; and regulation of establishment of blood-brain barrier. Located in cell surface and plasma membrane. Is expressed in several structures, including cardiovascular system; embryo mesenchyme; limb bud; mesonephros; and nose. Orthologous to human ADGRA2 (adhesion G protein-coupled receptor A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 39.8), limb E14.5 (RPKM 26.2) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Adgra2 in Genome Data Viewer
Location:
8 A2; 8 15.91 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (27575546..27613464)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (27085520..27123436)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ER lipid raft associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E4994 Neighboring gene STARR-seq mESC enhancer starr_21013 Neighboring gene pyridoxal phosphate binding protein Neighboring gene predicted gene, 39151 Neighboring gene VISTA enhancer mm136 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:28239113-28239296 Neighboring gene RIKEN cDNA 4933416M07 gene Neighboring gene BRF2, RNA polymerase III transcription initiation factor 50kDa subunit Neighboring gene RAB11 family interacting protein 1 (class I) Neighboring gene glutamic-oxaloacetic transaminase 1-like 1 Neighboring gene STARR-seq mESC enhancer starr_21022

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Specific Regulation of Wnt Bioavailability. Vallon M, et al. Cell Rep, 2018 Oct 9. PMID 30304675, Free PMC Article
  2. Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. Chang J, et al. Nat Med, 2017 Apr. PMID 28288111, Free PMC Article
  3. GPR124 functions as a WNT7-specific coactivator of canonical β-catenin signaling. Posokhova E, et al. Cell Rep, 2015 Jan 13. PMID 25558062, Free PMC Article
  4. Tumor endothelial marker 5 expression in endothelial cells during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of cell proliferation. Vallon M, et al. Exp Cell Res, 2010 Feb 1. PMID 19853600
  5. Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling. Zhou Y, et al. Dev Cell, 2014 Oct 27. PMID 25373781, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR124 induces NLRP3 inflammasome-mediated pyroptosis in endothelial cells during ischemic injury.
    Title: GPR124 induces NLRP3 inflammasome-mediated pyroptosis in endothelial cells during ischemic injury.
  2. An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates.
    Title: An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates.
  3. The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development.
    Title: The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development.
  4. experiments indicate that Reck and Gpr124 are part of the cell surface protein complex that transduces Wnt7a- and Wnt7b-specific signals in mammalian CNS Epithelial Cells to promote angiogenesis and regulate the BBB.
    Title: Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation.
  5. Gpr124 is an endothelial GPCR specifically required for endothelial Wnt signaling and BBB integrity under pathological conditions in adult mice.
    Title: Gpr124 is essential for blood-brain barrier integrity in central nervous system disease.
  6. Vital role for GPR124 is potentiation of WNT7-induced canonical beta-catenin signaling with important implications for understanding and manipulating CNS-specific angiogenesis.
    Title: GPR124 functions as a WNT7-specific coactivator of canonical β-catenin signaling.
  7. Gpr124 functions as coactivator of Wnt7a- and Wnt7b-stimulated canonical Wnt signaling via Frizzled receptor and Lrp coreceptor and that Gpr124-stimulated signaling functions in concert with Norrin/Frizzled4 signaling to control CNS vascular development
    Title: Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling.
  8. GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.
    Title: GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.
  9. TGF-beta stimulates Gpr124 expression which is required for angiogenic sprouting into neural tissues.
    Title: Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.
  10. study shows that complete null or endothelial-specific GPR124 deletion resulted in embryonic lethality from CNS-specific angiogenesis arrest in forebrain and neural tube; results demonstrate CNS-specific angiogenesis regulation by an endothelial receptor
    Title: Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (8)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of vascular endothelial growth factor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of establishment of blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of establishment of blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Wnt signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Wnt signalosome ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
adhesion G protein-coupled receptor A2
Names
G protein coupled receptor Gpr124
G-protein coupled receptor 124
tumor endothelial marker 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_054044.2 → NP_473385.2  adhesion G protein-coupled receptor A2 precursor

    See identical proteins and their annotated locations for NP_473385.2

    Status: VALIDATED

    Source sequence(s)
    AF378759, CJ243065
    Consensus CDS
    CCDS22210.2
    UniProtKB/Swiss-Prot
    B2RRK0, Q91ZV8
    UniProtKB/TrEMBL
    J3QMG7
    Related
    ENSMUSP00000033876.8, ENSMUST00000033876.14
    Conserved Domains (8) summary
    smart00082
    Location:192 → 225
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:88 → 166
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:88 → 109
    LRR_1; leucine-rich repeat [structural motif]
    pfam01825
    Location:709 → 750
    GPS; GPCR proteolysis site, GPS, motif
    pfam13855
    Location:88 → 144
    LRR_8; Leucine rich repeat
    cl02422
    Location:351 → 417
    HRM; Hormone receptor domain
    cl11960
    Location:257 → 343
    Ig; Immunoglobulin domain
    cl21561
    Location:776 → 944
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    27575546..27613464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509223.5 → XP_006509286.3  adhesion G protein-coupled receptor A2 isoform X2

    UniProtKB/TrEMBL
    J3QMG7
    Conserved Domains (7) summary
    PHA03307
    Location:1090 → 1301
    PHA03307; transcriptional regulator ICP4; Provisional
    COG4886
    Location:118 → 349
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:130 → 151
    LRR_1; leucine-rich repeat [structural motif]
    cd15998
    Location:806 → 1090
    7tmB2_GPR124; G protein-coupled receptor 124, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam13855
    Location:130 → 186
    LRR_8; Leucine rich repeat
    pfam01825
    Location:751 → 792
    GPS; GPCR proteolysis site, GPS, motif
    cl02422
    Location:393 → 459
    HRM; Hormone receptor domain

  2. XM_006509222.5 → XP_006509285.3  adhesion G protein-coupled receptor A2 isoform X1

    UniProtKB/TrEMBL
    J3QMG7
    Conserved Domains (8) summary
    PHA03307
    Location:1094 → 1305
    PHA03307; transcriptional regulator ICP4; Provisional
    COG4886
    Location:118 → 349
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:130 → 151
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:130 → 186
    LRR_8; Leucine rich repeat
    cd14964
    Location:808 → 833
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:751 → 792
    GPS; GPCR proteolysis site, GPS, motif
    cl02422
    Location:393 → 459
    HRM; Hormone receptor domain
    cl28897
    Location:806 → 1094
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_006509224.5 → XP_006509287.3  adhesion G protein-coupled receptor A2 isoform X3

    UniProtKB/TrEMBL
    A0A172Q382
    Conserved Domains (7) summary
    COG4886
    Location:118 → 349
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:130 → 151
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:130 → 186
    LRR_8; Leucine rich repeat
    cd14964
    Location:808 → 833
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:751 → 792
    GPS; GPCR proteolysis site, GPS, motif
    cl02422
    Location:393 → 459
    HRM; Hormone receptor domain
    cl28897
    Location:806 → 877
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RNA

  1. XR_001778488.3 RNA Sequence

  2. XR_003947355.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZV8.2 GenPept UniProtKB/Swiss-Prot:Q91ZV8

Gene LinkOut

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