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Htra3 HtrA serine peptidase 3 [ Mus musculus (house mouse) ]

Gene ID: 78558, updated on 21-Apr-2024

Summary

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Official Symbol
Htra3provided by MGI
Official Full Name
HtrA serine peptidase 3provided by MGI
Primary source
MGI:MGI:1925808
See related
Ensembl:ENSMUSG00000029096 AllianceGenome:MGI:1925808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prsp; Tasp; 2210021K23Rik; 9530081K03Rik
Summary
Enables serine-type peptidase activity. Involved in negative regulation of BMP signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; and proteolysis. Predicted to be located in extracellular region. Is expressed in decidua; decidua basalis; and decidua capsularis. Orthologous to human HTRA3 (HtrA serine peptidase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 98.7), subcutaneous fat pad adult (RPKM 87.5) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 B3; 5 18.49 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (35809370..35837157, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (35652026..35679813, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12858 Neighboring gene RIKEN cDNA 4931431C16 gene Neighboring gene polo like kinase, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E3570 Neighboring gene tRNA methyltransferase 44 Neighboring gene STARR-positive B cell enhancer ABC_E11725 Neighboring gene acyl-Coenzyme A oxidase 3, pristanoyl Neighboring gene STARR-seq mESC enhancer starr_12860 Neighboring gene SH3 domain and tetratricopeptide repeats 1 Neighboring gene predicted gene, 31888 Neighboring gene STARR-positive B cell enhancer ABC_E8820 Neighboring gene actin-binding LIM protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-temperature requirement factor A3 (Htra3): a novel serine protease and its potential role in ovarian function and ovarian cancers. Bowden MA, et al. Mol Cell Endocrinol, 2010 Oct 7. PMID 20540986
  2. HtrA3, a serine protease possessing an IGF-binding domain, is selectively expressed at the maternal-fetal interface during placentation in the mouse. Nie G, et al. Placenta, 2006 Apr-May. PMID 15951015
  3. A novel serine protease of the mammalian HtrA family is up-regulated in mouse uterus coinciding with placentation. Nie GY, et al. Mol Hum Reprod, 2003 May. PMID 12728021
  4. Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood. Li Y, et al. Sci Rep, 2017 Jul 4. PMID 28676687, Free PMC Article
  5. The Scleraxis Transcription Factor Directly Regulates Multiple Distinct Molecular and Cellular Processes During Early Tendon Cell Differentiation. Liu H, et al. Front Cell Dev Biol, 2021. PMID 34150754, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that HtrA3 deletion in the mother resulted in intra-uterine growth restriction (IUGR). Disorganization of labyrinthine fetal capillaries was the major placental defect when HtrA3 was absent. Mice born to HtrA3-deficient mothers, independent of their own genotype, were significantly heavier and contained a larger mass of white fat.
    Title: Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood.
  2. Both mRNA and protein of HtrA3 were localized specifically in the maternal decidua. Only the maternal decidual cells, but not blood vessels or uterine NK cells that are present in large numbers, were positive for HtrA3.
    Title: HtrA3, a serine protease possessing an IGF-binding domain, is selectively expressed at the maternal-fetal interface during placentation in the mouse.
  3. Plays an important role in the formation/function of the placenta.
    Title: A novel serine protease of the mammalian HtrA family is up-regulated in mouse uterus coinciding with placentation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine protease HTRA3
Names
high-temperature requirement factor A3
pregnancy-related serine protease
probable serine protease HTRA3
toll-associated serine protease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042615.2 → NP_001036080.1  serine protease HTRA3 isoform b precursor

    See identical proteins and their annotated locations for NP_001036080.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AI481644, AK008764, AK035194, AY156509
    Consensus CDS
    CCDS39071.1
    UniProtKB/Swiss-Prot
    Q9D236
    Related
    ENSMUSP00000109871.3, ENSMUST00000114233.3
    Conserved Domains (3) summary
    pfam00219
    Location:31 → 82
    IGFBP; Insulin-like growth factor binding protein
    pfam07648
    Location:87 → 132
    Kazal_2; Kazal-type serine protease inhibitor domain
    pfam13365
    Location:181 → 325
    Trypsin_2; Trypsin-like peptidase domain

  2. NM_030127.3 → NP_084403.2  serine protease HTRA3 isoform a precursor

    See identical proteins and their annotated locations for NP_084403.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK008764, AK020653, AK035194, AY156509
    Consensus CDS
    CCDS19233.1
    UniProtKB/Swiss-Prot
    B2RRV0, Q6WLC5, Q6YDR0, Q9D236
    Related
    ENSMUSP00000084910.4, ENSMUST00000087629.10
    Conserved Domains (4) summary
    cd00987
    Location:361 → 446
    PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
    pfam00219
    Location:31 → 82
    IGFBP; Insulin-like growth factor binding protein
    pfam07648
    Location:87 → 132
    Kazal_2; Kazal-type serine protease inhibitor domain
    pfam13365
    Location:181 → 325
    Trypsin_2; Trypsin-like peptidase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    35809370..35837157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504186.2 → XP_006504249.1  serine protease HTRA3 isoform X1

    Conserved Domains (3) summary
    TIGR02037
    Location:149 → 440
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    pfam00219
    Location:31 → 82
    IGFBP; Insulin-like growth factor binding protein
    pfam07648
    Location:95 → 132
    Kazal_2; Kazal-type serine protease inhibitor domain

  2. XM_030254908.2 → XP_030110768.1  serine protease HTRA3 isoform X3

    Conserved Domains (1) summary
    TIGR02037
    Location:1 → 247
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

  3. XM_011240796.4 → XP_011239098.1  serine protease HTRA3 isoform X2

    Conserved Domains (1) summary
    TIGR02037
    Location:1 → 255
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

RNA

  1. XR_004942587.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D236.3 GenPept UniProtKB/Swiss-Prot:Q9D236

Gene LinkOut

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