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Rnase6 ribonuclease, RNase A family, 6 [ Mus musculus (house mouse) ]

Gene ID: 78416, updated on 5-Mar-2024

Summary

Official Symbol
Rnase6provided by MGI
Official Full Name
ribonuclease, RNase A family, 6provided by MGI
Primary source
MGI:MGI:1925666
See related
Ensembl:ENSMUSG00000021880 AllianceGenome:MGI:1925666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9530043P15Rik
Summary
Predicted to enable ribonuclease activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and defense response to other organism. Located in extracellular space. Orthologous to human RNASE6 (ribonuclease A family member k6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 17.8), mammary gland adult (RPKM 6.0) and 8 other tissues See more
Orthologs
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Genomic context

Location:
14 C1; 14 26.39 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51361365..51369644)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (51123908..51132187)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ribonuclease, RNase A family 4 Neighboring gene STARR-positive B cell enhancer ABC_E4108 Neighboring gene angiogenin, ribonuclease, RNase A family, 5 Neighboring gene epididymal protein 3B Neighboring gene STARR-positive B cell enhancer ABC_E9895 Neighboring gene ribonuclease, RNase A family, 1 (pancreatic) Neighboring gene ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA nuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA nuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in antibacterial humoral response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribonuclease K6
Names
RNase K6
ribonuclease A family, member 6
NP_001347046.1
NP_084374.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360117.1NP_001347046.1  ribonuclease K6 precursor

    Status: VALIDATED

    Source sequence(s)
    AK038708, BG091045
    Consensus CDS
    CCDS27037.1
    UniProtKB/Swiss-Prot
    A2RTT6, Q6QDX5, Q9D244
    UniProtKB/TrEMBL
    Q3V3L3, W0UTF2
    Related
    ENSMUSP00000154125.2, ENSMUST00000226194.2
    Conserved Domains (1) summary
    pfam00074
    Location:33150
    RnaseA; Pancreatic ribonuclease
  2. NM_030098.3NP_084374.2  ribonuclease K6 precursor

    See identical proteins and their annotated locations for NP_084374.2

    Status: VALIDATED

    Source sequence(s)
    AA182060, AK020595, AK038708, BG091045
    Consensus CDS
    CCDS27037.1
    UniProtKB/Swiss-Prot
    A2RTT6, Q6QDX5, Q9D244
    UniProtKB/TrEMBL
    Q3V3L3, W0UTF2
    Related
    ENSMUSP00000093613.4, ENSMUST00000095923.4
    Conserved Domains (1) summary
    pfam00074
    Location:33150
    RnaseA; Pancreatic ribonuclease

RNA

  1. NR_153407.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA182060, AK038708, BE687377, BG091045

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    51361365..51369644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)