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Cyren cell cycle regulator of NHEJ [ Mus musculus (house mouse) ]

Gene ID: 78412, updated on 5-Mar-2024

Summary

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Official Symbol
Cyrenprovided by MGI
Official Full Name
cell cycle regulator of NHEJprovided by MGI
Primary source
MGI:MGI:1925662
See related
Ensembl:ENSMUSG00000046806 AllianceGenome:MGI:1925662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mri; 3110062M04Rik
Summary
Involved in double-strand break repair via nonhomologous end joining and immunoglobulin V(D)J recombination. Is active in site of double-strand break. Is expressed in several structures, including adipose tissue; alimentary system; eye; male reproductive gland or organ; and nervous system. Orthologous to human CYREN (cell cycle regulator of NHEJ). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 19.4), subcutaneous fat pad adult (RPKM 12.4) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B1; 6 15.18 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (34848706..34855024, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (34871771..34878065, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein-like 3 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 46957 Neighboring gene transmembrane protein 140 Neighboring gene WD repeat domain 91 Neighboring gene STARR-positive B cell enhancer mm9_chr6:34860831-34861132 Neighboring gene stimulated by retinoic acid gene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Generation of a Mouse Model Lacking the Non-Homologous End-Joining Factor Mri/Cyren. Castañeda-Zegarra S, et al. Biomolecules, 2019 Nov 28. PMID 31795137, Free PMC Article
  2. Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI. Castañeda-Zegarra S, et al. Aging (Albany NY), 2020 Dec 7. PMID 33289702, Free PMC Article
  3. Isolation, characterization, and genetic complementation of a cellular mutant resistant to retroviral infection. Agarwal S, et al. Proc Natl Acad Sci U S A, 2006 Oct 24. PMID 17043244, Free PMC Article
  4. MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Hung PJ, et al. Mol Cell, 2018 Jul 19. PMID 30017584, Free PMC Article
  5. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI.
    Title: Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI.
  2. Characterizes the hamster ortholog and suggests that it may modulate the ability of the proteasome to degrade retroviral cores upon cellular infection.
    Title: Isolation, characterization, and genetic complementation of a cellular mutant resistant to retroviral infection.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
  
involved_in immunoglobulin V(D)J recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cell cycle regulator of non-homologous end joining
Names
modulator of retrovirus infection homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135611.1 → NP_001129083.1  cell cycle regulator of non-homologous end joining isoform 1

    See identical proteins and their annotated locations for NP_001129083.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AK042380, AK083365, BB611813
    Consensus CDS
    CCDS19997.1
    UniProtKB/Swiss-Prot
    Q8BHZ5, Q8K0Y5
    Related
    ENSMUSP00000110659.3, ENSMUST00000115007.9
    Conserved Domains (1) summary
    pfam15325
    Location:55 → 157
    MRI; Modulator of retrovirus infection

  2. NM_001347101.1 → NP_001334030.1  cell cycle regulator of non-homologous end joining isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and in the 3' coding region, compared to variant 1. These differences result in a longer isoform (2), compared to isoform 1.
    Source sequence(s)
    AC153869
    Consensus CDS
    CCDS85030.1
    UniProtKB/Swiss-Prot
    Q8BHZ5
    Related
    ENSMUSP00000110658.2, ENSMUST00000115006.2

  3. NM_199145.2 → NP_954596.1  cell cycle regulator of non-homologous end joining isoform 1

    See identical proteins and their annotated locations for NP_954596.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AK042380, BB611813
    Consensus CDS
    CCDS19997.1
    UniProtKB/Swiss-Prot
    Q8BHZ5, Q8K0Y5
    Related
    ENSMUSP00000053349.5, ENSMUST00000055097.11
    Conserved Domains (1) summary
    pfam15325
    Location:55 → 157
    MRI; Modulator of retrovirus infection

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    34848706..34855024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255676.2 → XP_030111536.1  cell cycle regulator of non-homologous end joining isoform X1

    UniProtKB/Swiss-Prot
    Q8BHZ5, Q8K0Y5
    Conserved Domains (1) summary
    pfam15325
    Location:55 → 157
    MRI; Modulator of retrovirus infection
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHZ5.1 GenPept UniProtKB/Swiss-Prot:Q8BHZ5

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