U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ttyh3 tweety family member 3 [ Mus musculus (house mouse) ]

Gene ID: 78339, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Ttyh3provided by MGI
Official Full Name
tweety family member 3provided by MGI
Primary source
MGI:MGI:1925589
See related
Ensembl:ENSMUSG00000036565 AllianceGenome:MGI:1925589
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TTY3; mTTY3; 2900029G13Rik
Summary
Predicted to enable intracellular calcium activated chloride channel activity and volume-sensitive chloride channel activity. Predicted to be involved in chloride transport. Predicted to act upstream of or within ion transport. Predicted to be integral component of membrane. Predicted to be part of chloride channel complex. Predicted to be active in plasma membrane. Is expressed in retina. Orthologous to human TTYH3 (tweety family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 79.8), whole brain E14.5 (RPKM 56.1) and 26 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
5 G2; 5 79.16 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (140606332..140634826, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (140620577..140649071, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:141072932-141073102 Neighboring gene predicted gene, 30603 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:141093710-141094027 Neighboring gene STARR-positive B cell enhancer ABC_E11729 Neighboring gene LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E6392 Neighboring gene IQ motif containing E Neighboring gene STARR-positive B cell enhancer ABC_E11307 Neighboring gene BRCA1-associated ATM activator 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca(2+)-dependent switch from intra- to intermembrane dimerization. Li B, et al. Nat Commun, 2021 Nov 25. PMID 34824283, Free PMC Article
  2. Quantitative expression analyses of candidates for alternative anion conductance in cystic fibrosis mouse models. Braun J, et al. J Cyst Fibros, 2010 Sep. PMID 20624691
  3. The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels. He Y, et al. J Biol Chem, 2008 Aug 29. PMID 18577513, Free PMC Article
  4. A novel human Cl(-) channel family related to Drosophila flightless locus. Suzuki M, et al. J Biol Chem, 2004 May 21. PMID 15010458
  5. Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas. Templin JS, et al. Brain Res, 2012 May 31. PMID 22534482, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca(2+)-dependent switch from intra- to intermembrane dimerization.
    Title: Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca(2+)-dependent switch from intra- to intermembrane dimerization.
  2. This study demonistrated that Ttyh3 gene expression in mouse dorsal raphe nucleus
    Title: Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
  3. Down-regulation of mTTYH3 may point towards its involvement in complex cystic fibrosis pathology. However, markedly reduced expression argues against direct compensatory action as alternative anion conductance.
    Title: Quantitative expression analyses of candidates for alternative anion conductance in cystic fibrosis mouse models.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
enables intracellularly calcium-gated chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intracellularly calcium-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
enables volume-sensitive chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables volume-sensitive chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-glutamate transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein tweety homolog 3
Names
tweety homolog 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308040.1 → NP_001294969.1  protein tweety homolog 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region, resulting in a frameshift, compared to variant 2. The encoded isoform (3) has a shorter and distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AI843734, BC059083, BC062917
    Consensus CDS
    CCDS80450.1
    UniProtKB/Swiss-Prot
    Q6P5F7
    Related
    ENSMUSP00000142655.2, ENSMUST00000197452.5
    Conserved Domains (1) summary
    pfam04906
    Location:25 → 430
    Tweety; Tweety

  2. NM_175274.5 → NP_780483.2  protein tweety homolog 3 isoform 2

    See identical proteins and their annotated locations for NP_780483.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AI843734, BC062917
    Consensus CDS
    CCDS19822.1
    UniProtKB/Swiss-Prot
    Q69ZD3, Q6P5F7, Q6PCX0, Q8C789
    Related
    ENSMUSP00000037447.4, ENSMUST00000042661.8
    Conserved Domains (1) summary
    pfam04906
    Location:25 → 430
    Tweety; Tweety

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    140606332..140634826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321177.2 → XP_017176666.1  protein tweety homolog 3 isoform X3

    Conserved Domains (1) summary
    pfam04906
    Location:25 → 430
    Tweety

  2. XM_030254906.2 → XP_030110766.1  protein tweety homolog 3 isoform X2

    Conserved Domains (1) summary
    pfam04906
    Location:80 → 447
    Tweety

  3. XM_030254907.2 → XP_030110767.1  protein tweety homolog 3 isoform X4

    Conserved Domains (1) summary
    pfam04906
    Location:80 → 447
    Tweety

  4. XM_030254905.2 → XP_030110765.1  protein tweety homolog 3 isoform X1

    Conserved Domains (1) summary
    pfam04906
    Location:80 → 447
    Tweety

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001308039.1: Suppressed sequence

    Description
    NM_001308039.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P5F7.1 GenPept UniProtKB/Swiss-Prot:Q6P5F7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous