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Cdk19 cyclin dependent kinase 19 [ Mus musculus (house mouse) ]

Gene ID: 78334, updated on 11-Apr-2024

Summary

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Official Symbol
Cdk19provided by MGI
Official Full Name
cyclin dependent kinase 19provided by MGI
Primary source
MGI:MGI:1925584
See related
Ensembl:ENSMUSG00000038481 AllianceGenome:MGI:1925584
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CDK11; Cdc2l6; mKIAA1028; 2700084L06Rik
Summary
Predicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in positive regulation of apoptotic process; positive regulation of inflammatory response; and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytoplasm. Predicted to be part of mediator complex. Predicted to be active in cytosol and nucleus. Is expressed in endolymphatic appendage and otocyst. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 87. Orthologous to human CDK19 (cyclin dependent kinase 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 11.6), cortex adult (RPKM 9.7) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B1; 10 21.94 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (40225283..40359814)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (40349287..40483818)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2319 Neighboring gene S-adenosylmethionine decarboxylase 1 Neighboring gene STARR-seq mESC enhancer starr_26414 Neighboring gene STARR-positive B cell enhancer ABC_E136 Neighboring gene STARR-positive B cell enhancer ABC_E5126 Neighboring gene STARR-positive B cell enhancer ABC_E6831 Neighboring gene predicted gene 8948 Neighboring gene STARR-seq mESC enhancer starr_26416 Neighboring gene STARR-seq mESC enhancer starr_26417 Neighboring gene STARR-seq mESC enhancer starr_26418 Neighboring gene high mobility group box 1-like pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6832 Neighboring gene predicted gene, 32234 Neighboring gene STARR-positive B cell enhancer ABC_E6833 Neighboring gene STARR-seq mESC enhancer starr_26425 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:40235225-40235444 Neighboring gene STARR-positive B cell enhancer ABC_E10601 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:40247394-40247503 Neighboring gene STARR-seq mESC enhancer starr_26426 Neighboring gene STARR-seq mESC enhancer starr_26427 Neighboring gene small nuclear ribonucleoprotein B pseudogene Neighboring gene predicted gene, 17795

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium. Prieto S, et al. EMBO Rep, 2023 Feb 6. PMID 36545778, Free PMC Article
  2. CDK19 regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells by suppressing p53-mediated transcription of p21. Zhang Z, et al. Leukemia, 2022 Apr. PMID 35110726
  3. CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF. Dannappel MV, et al. J Clin Invest, 2022 Oct 17. PMID 36006697, Free PMC Article
  4. Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development. Postlmayr A, et al. Development, 2020 Jun 11. PMID 32439758, Free PMC Article
  5. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.
    Title: CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 19
Names
CDC2-related protein kinase 6
cell division cycle 2-like 6 (CDK8-like)
cell division cycle 2-like protein kinase 6
cell division protein kinase 19
cyclin-dependent kinase (CDC2-like) 11
cyclin-dependent kinase 11
NP_001161776.1
NP_001278745.1
NP_001278746.1
NP_937807.2
XP_017169653.1
XP_030101250.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168304.1 → NP_001161776.1  cyclin-dependent kinase 19 isoform 1

    See identical proteins and their annotated locations for NP_001161776.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC142273, AC157652, AK053651, BC080280
    Consensus CDS
    CCDS48545.1
    UniProtKB/Swiss-Prot
    Q80TM1, Q8BWD8
    UniProtKB/TrEMBL
    B7ZMT1, Q8BKC7
    Related
    ENSMUSP00000040936.5, ENSMUST00000044672.11
    Conserved Domains (2) summary
    smart00220
    Location:22 → 335
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07867
    Location:18 → 335
    STKc_CDC2L6; Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6

  2. NM_001291816.1 → NP_001278745.1  cyclin-dependent kinase 19 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC142273, AK147340, BC080280
    Conserved Domains (1) summary
    cl21453
    Location:1 → 215
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001291817.1 → NP_001278746.1  cyclin-dependent kinase 19 isoform 4

    See identical proteins and their annotated locations for NP_001278746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC142273, AK147340, BC062100, BC080280
    Conserved Domains (1) summary
    cl21453
    Location:1 → 162
    PKc_like; Protein Kinases, catalytic domain

  4. NM_198164.3 → NP_937807.2  cyclin-dependent kinase 19 isoform 2

    See identical proteins and their annotated locations for NP_937807.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a short protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC142273, AK053651, AK147340, BC080280
    Consensus CDS
    CCDS23795.1
    UniProtKB/TrEMBL
    G5E8L1, Q8BKC7
    Related
    ENSMUSP00000093414.3, ENSMUST00000095743.4
    Conserved Domains (2) summary
    smart00220
    Location:22 → 291
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:18 → 291
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    40225283..40359814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245390.1 → XP_030101250.1  cyclin-dependent kinase 19 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1 → 162
    PKc_like; Protein Kinases, catalytic domain

  2. XM_017314164.3 → XP_017169653.1  cyclin-dependent kinase 19 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1 → 215
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BWD8.1 GenPept UniProtKB/Swiss-Prot:Q8BWD8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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