Ankrd23 ankyrin repeat domain 23 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ankrd23provided by MGI
Official Full Name: ankyrin repeat domain 23provided by MGI
Primary source: MGI:MGI:1925571
See related: Ensembl:ENSMUSG00000067653 AllianceGenome:MGI:1925571
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Darp; MARP3; Gm42417; 1110058D09Rik; 2310041C05Rik
Summary: Predicted to enable titin binding activity. Acts upstream of or within fatty acid metabolic process; regulation of sarcomere organization; and response to muscle stretch. Located in I band and nucleus. Orthologous to human ANKRD23 (ankyrin repeat domain 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 131.5), mammary gland adult (RPKM 88.2) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1; 1 B

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (36569269..36578380, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (36530193..36536556, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ankrd23(-/-) mice exhibit limited ability to form collateral arteries following femoral artery occlusion compared to WT mice. Further research will be required to determine whether Ankrd23 plays an important role in mechanically induced vascular remodeling of the arterial tree in skeletal muscle.
Title: Vascular cell transcriptomic changes to exercise training differ directionally along and between skeletal muscle arteriolar trees.
Results showed expression of myoblast differentiation marker genes were increased by interference and reduced by ANKRD23 overexpression, indicating that ANKRD23 played a negative role in the myoblast differentiation; discovered a long non-coding RNA-AK004293 which was overlapped with the 3'UTR of ANKRD23 gene. Thus, AK004293 had no significant effect on the expression of myoblast differentiation maker genes and ANKRD23.
Title: The nuclear protein-coding gene ANKRD23 negatively regulates myoblast differentiation.
DARP regulates glucose disposal in skeletal muscle and thus modifies the glucose homeostasis by modulating AMPK activity.
Title: Diabetes-Related Ankyrin Repeat Protein (DARP/Ankrd23) Modifies Glucose Homeostasis by Modulating AMPK Activity in Skeletal Muscle.
CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to mechanical pressure overload.
Title: The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload.
Dapr is involved in the PI3K signaling cascade, potentially acting as a scaffold protein for PKB and coordinating its compartmentalization during differentiation.
Title: Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling.
DARP plays important structural and gene regulatory roles in skeletal muscle.
Title: Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle.
investigation of potential role in energy metabolism
Title: Molecular identification and characterization of a novel nuclear protein whose expression is up-regulated in insulin-resistant animals.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables titin binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of sarcomere organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to muscle stretch	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in I band	IDA Inferred from Direct Assay more info	PubMed
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in myofibril	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ankyrin repeat domain-containing protein 23

Names: diabetes-realted ankyrin repeat protein; diabetes-related ankyrin repeat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310521.1 → NP_001297450.1 ankyrin repeat domain-containing protein 23 isoform 2

See identical proteins and their annotated locations for NP_001297450.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate 5' exon compared to variant 1, which results in translation initiation from a downstream AUG. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AF492400, BC022973, CX224440

Consensus CDS

CCDS78564.1

UniProtKB/TrEMBL

A0A0A6YW48

Related

ENSMUSP00000141394.2, ENSMUST00000193083.6

Conserved Domains (4) summary

PHA02736
Location:101 → 172

PHA02736; Viral ankyrin protein; Provisional

sd00045
Location:65 → 94

ANK; ANK repeat [structural motif]

pfam13637
Location:4 → 51

Ank_4; Ankyrin repeats (many copies)

pfam12796
Location:35 → 127

Ank_2; Ankyrin repeats (3 copies)
NM_153502.4 → NP_705722.2 ankyrin repeat domain-containing protein 23 isoform 1

See identical proteins and their annotated locations for NP_705722.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AF492400, BC022973, BC132370

Consensus CDS

CCDS14882.1

UniProtKB/Swiss-Prot

Q812A3

UniProtKB/TrEMBL

A2RT50, B7ZNT7

Related

ENSMUSP00000061168.5, ENSMUST00000054665.10

Conserved Domains (5) summary

cd00204
Location:139 → 264

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:149 → 241

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:118 → 165

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:230 → 284

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:179 → 208

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

36569269..36578380 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154421.1 → XP_036010314.1 ankyrin repeat domain-containing protein 23 isoform X1

UniProtKB/TrEMBL

A0A0A6YW48

Conserved Domains (4) summary

PHA02736
Location:101 → 172

PHA02736; Viral ankyrin protein; Provisional

sd00045
Location:65 → 94

ANK; ANK repeat [structural motif]

pfam13637
Location:4 → 51

Ank_4; Ankyrin repeats (many copies)

pfam12796
Location:35 → 127

Ank_2; Ankyrin repeats (3 copies)
XM_036154417.1 → XP_036010310.1 ankyrin repeat domain-containing protein 23 isoform X1

UniProtKB/TrEMBL

A0A0A6YW48

Conserved Domains (4) summary

PHA02736
Location:101 → 172

PHA02736; Viral ankyrin protein; Provisional

sd00045
Location:65 → 94

ANK; ANK repeat [structural motif]

pfam13637
Location:4 → 51

Ank_4; Ankyrin repeats (many copies)

pfam12796
Location:35 → 127

Ank_2; Ankyrin repeats (3 copies)
XM_036154424.1 → XP_036010317.1 ankyrin repeat domain-containing protein 23 isoform X1

UniProtKB/TrEMBL

A0A0A6YW48

Conserved Domains (4) summary

PHA02736
Location:101 → 172

PHA02736; Viral ankyrin protein; Provisional

sd00045
Location:65 → 94

ANK; ANK repeat [structural motif]

pfam13637
Location:4 → 51

Ank_4; Ankyrin repeats (many copies)

pfam12796
Location:35 → 127

Ank_2; Ankyrin repeats (3 copies)