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Klhdc8b kelch domain containing 8B [ Mus musculus (house mouse) ]

Gene ID: 78267, updated on 5-Mar-2024

Summary

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Official Symbol
Klhdc8bprovided by MGI
Official Full Name
kelch domain containing 8Bprovided by MGI
Primary source
MGI:MGI:1925517
See related
Ensembl:ENSMUSG00000032609 AllianceGenome:MGI:1925517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4931406O17Rik
Summary
Predicted to be involved in mitotic cytokinetic process; mitotic nuclear division; and nuclear chromosome segregation. Predicted to act upstream of or within cell division. Predicted to be located in several cellular components, including cellularization cleavage furrow; intercellular bridge; and midbody. Is expressed in heart. Human ortholog(s) of this gene implicated in Hodgkin's lymphoma. Orthologous to human KLHDC8B (kelch domain containing 8B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 16.4), ovary adult (RPKM 13.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F2; 9 59.37 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108324834..108338780, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108447635..108461581, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene interactor of HORMAD1 1 Neighboring gene predicted gene, 25456 Neighboring gene cDNA sequence BC048562 Neighboring gene coiled-coil domain containing 71 Neighboring gene microRNA 12206 Neighboring gene laminin, beta 2 Neighboring gene STARR-positive B cell enhancer ABC_E2916 Neighboring gene ubiquitin specific peptidase 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Efficient capture of cardiogenesis-associated genes expressed in ES cells. Terami H, et al. Biochem Biophys Res Commun, 2007 Mar 30. PMID 17286962
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cytokinetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellularization cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cellularization cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in intercellular bridge IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch domain-containing protein 8B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359428.1 → NP_001346357.1  kelch domain-containing protein 8B

    Status: VALIDATED

    Source sequence(s)
    AC161260
    Consensus CDS
    CCDS23526.1
    UniProtKB/Swiss-Prot
    Q9D2D9
    Related
    ENSMUSP00000035232.8, ENSMUST00000035232.13
    Conserved Domains (2) summary
    PHA03098
    Location:7 → 210
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:69 → 113
    Kelch; KELCH repeat [structural motif]

  2. NM_030075.2 → NP_084351.1  kelch domain-containing protein 8B

    See identical proteins and their annotated locations for NP_084351.1

    Status: VALIDATED

    Source sequence(s)
    AK019849, CA750541
    Consensus CDS
    CCDS23526.1
    UniProtKB/Swiss-Prot
    Q9D2D9
    Related
    ENSMUSP00000142325.2, ENSMUST00000193286.6
    Conserved Domains (2) summary
    PHA03098
    Location:7 → 210
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:69 → 113
    Kelch; KELCH repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    108324834..108338780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244718.2 → XP_030100578.1  kelch domain-containing protein 8B isoform X1

    UniProtKB/Swiss-Prot
    Q9D2D9
    Conserved Domains (2) summary
    PHA03098
    Location:7 → 210
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:69 → 113
    Kelch; KELCH repeat [structural motif]

  2. XM_030244724.2 → XP_030100584.1  kelch domain-containing protein 8B isoform X1

    UniProtKB/Swiss-Prot
    Q9D2D9
    Conserved Domains (2) summary
    PHA03098
    Location:7 → 210
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:69 → 113
    Kelch; KELCH repeat [structural motif]

  3. XM_030244721.2 → XP_030100581.1  kelch domain-containing protein 8B isoform X1

    UniProtKB/Swiss-Prot
    Q9D2D9
    Conserved Domains (2) summary
    PHA03098
    Location:7 → 210
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:69 → 113
    Kelch; KELCH repeat [structural motif]

  4. XM_030244716.2 → XP_030100576.1  kelch domain-containing protein 8B isoform X1

    UniProtKB/Swiss-Prot
    Q9D2D9
    Related
    ENSMUSP00000141453.2, ENSMUST00000193895.6
    Conserved Domains (2) summary
    PHA03098
    Location:7 → 210
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:69 → 113
    Kelch; KELCH repeat [structural motif]

  5. XM_036155408.1 → XP_036011301.1  kelch domain-containing protein 8B isoform X1

    UniProtKB/Swiss-Prot
    Q9D2D9
    Conserved Domains (2) summary
    PHA03098
    Location:7 → 210
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:69 → 113
    Kelch; KELCH repeat [structural motif]

  6. XM_030244719.2 → XP_030100579.1  kelch domain-containing protein 8B isoform X1

    UniProtKB/Swiss-Prot
    Q9D2D9
    Conserved Domains (2) summary
    PHA03098
    Location:7 → 210
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:69 → 113
    Kelch; KELCH repeat [structural motif]

  7. XM_030244723.2 → XP_030100583.1  kelch domain-containing protein 8B isoform X1

    UniProtKB/Swiss-Prot
    Q9D2D9
    Conserved Domains (2) summary
    PHA03098
    Location:7 → 210
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:69 → 113
    Kelch; KELCH repeat [structural motif]

  8. XM_030244717.2 → XP_030100577.1  kelch domain-containing protein 8B isoform X1

    UniProtKB/Swiss-Prot
    Q9D2D9
    Conserved Domains (2) summary
    PHA03098
    Location:7 → 210
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:69 → 113
    Kelch; KELCH repeat [structural motif]

  9. XM_030244725.1 → XP_030100585.1  kelch domain-containing protein 8B isoform X2

    Conserved Domains (2) summary
    PHA03098
    Location:2 → 209
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:39 → 81
    Kelch; KELCH repeat [structural motif]

  10. XM_006511858.3 → XP_006511921.1  kelch domain-containing protein 8B isoform X2

    See identical proteins and their annotated locations for XP_006511921.1

    Conserved Domains (2) summary
    PHA03098
    Location:2 → 209
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:39 → 81
    Kelch; KELCH repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2D9.1 GenPept UniProtKB/Swiss-Prot:Q9D2D9

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