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Ralgps2 Ral GEF with PH domain and SH3 binding motif 2 [ Mus musculus (house mouse) ]

Gene ID: 78255, updated on 11-Apr-2024

Summary

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Official Symbol
Ralgps2provided by MGI
Official Full Name
Ral GEF with PH domain and SH3 binding motif 2provided by MGI
Primary source
MGI:MGI:1925505
See related
Ensembl:ENSMUSG00000026594 AllianceGenome:MGI:1925505
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810020P17Rik; 2210408F11Rik; 4921528G01Rik; 9130014M22Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Ral protein signal transduction and small GTPase mediated signal transduction. Predicted to be located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; cranial ganglion; eye; limb bud; and limb segment. Orthologous to human RALGPS2 (Ral GEF with PH domain and SH3 binding motif 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 13.7), CNS E14 (RPKM 8.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 G3; 1 67.71 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (156631736..156767422, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (156804166..156939850, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr1:158682524-158682825 Neighboring gene predicted gene, 39683 Neighboring gene PCNA-associated factor pseudogene Neighboring gene angiopoietin-like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:158834070-158834253 Neighboring gene STARR-positive B cell enhancer ABC_E2572 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:158863932-158864133 Neighboring gene RIKEN cDNA 4930439D14 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:158868943-158869130 Neighboring gene STARR-positive B cell enhancer ABC_E9487 Neighboring gene STARR-seq mESC enhancer starr_02758 Neighboring gene STARR-positive B cell enhancer ABC_E5828 Neighboring gene STARR-positive B cell enhancer ABC_E4364 Neighboring gene STARR-seq mESC enhancer starr_02759 Neighboring gene STARR-positive B cell enhancer ABC_E2573 Neighboring gene STARR-positive B cell enhancer ABC_E3318 Neighboring gene predicted gene, 39685 Neighboring gene STARR-positive B cell enhancer ABC_E1569 Neighboring gene STARR-positive B cell enhancer mm9_chr1:158957909-158958210 Neighboring gene STARR-seq mESC enhancer starr_02761 Neighboring gene STARR-positive B cell enhancer ABC_E7762 Neighboring gene STARR-positive B cell enhancer ABC_E1232 Neighboring gene STARR-seq mESC enhancer starr_02762 Neighboring gene STARR-positive B cell enhancer ABC_E7763 Neighboring gene predicted gene, 30568

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a new Ral-GEF expressed in mouse testis. Martegani E, et al. Ann N Y Acad Sci, 2002 Nov. PMID 12485849
  2. Functional analysis of RalGPS2, a murine guanine nucleotide exchange factor for RalA GTPase. Ceriani M, et al. Exp Cell Res, 2007 Jul 1. PMID 17462626
  3. Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral. Rebhun JF, et al. J Biol Chem, 2000 May 5. PMID 10747847
  4. ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development. Rohacek AM, et al. Dev Cell, 2017 Nov 6. PMID 29107558, Free PMC Article
  5. The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Bebee TW, et al. Elife, 2015 Sep 15. PMID 26371508, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RalGPS2 was characterized.
    Title: Functional analysis of RalGPS2, a murine guanine nucleotide exchange factor for RalA GTPase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-specific guanine nucleotide-releasing factor RalGPS2
Names
ral GEF with PH domain and SH3-binding motif 2
ralA exchange factor RalGPS2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159965.1 → NP_001153437.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform a

    See identical proteins and their annotated locations for NP_001153437.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longest isoform (a). Variants 1, 2, and 3 all encode isoform a.
    Source sequence(s)
    AC138109, AK019543, AK033549, BC052663, CJ104104
    Consensus CDS
    CCDS15396.1
    UniProtKB/Swiss-Prot
    Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6
    UniProtKB/TrEMBL
    Q8C134
    Related
    ENSMUSP00000063872.7, ENSMUST00000063199.13
    Conserved Domains (2) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:466 → 581
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  2. NM_001159966.1 → NP_001153438.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform a

    See identical proteins and their annotated locations for NP_001153438.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.
    Source sequence(s)
    AC138109, AK019543, AK033549
    Consensus CDS
    CCDS15396.1
    UniProtKB/Swiss-Prot
    Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6
    UniProtKB/TrEMBL
    Q8C134
    Related
    ENSMUSP00000130581.2, ENSMUST00000171292.8
    Conserved Domains (2) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:466 → 581
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  3. NM_001159967.1 → NP_001153439.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform b

    See identical proteins and their annotated locations for NP_001153439.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC138109, AK169368, CJ104104
    Consensus CDS
    CCDS48406.1
    UniProtKB/TrEMBL
    Q8C134
    Related
    ENSMUSP00000027886.8, ENSMUST00000027886.14
    Conserved Domains (2) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:440 → 555
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  4. NM_001159968.1 → NP_001153440.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform c

    See identical proteins and their annotated locations for NP_001153440.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC138109, AK036803, CJ104104
    Consensus CDS
    CCDS48405.1
    UniProtKB/TrEMBL
    Q8C134
    Related
    ENSMUSP00000132533.2, ENSMUST00000172057.8
    Conserved Domains (3) summary
    smart00147
    Location:21 → 251
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:431 → 546
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:430 → 540
    PH; PH domain

  5. NM_001357391.1 → NP_001344320.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AC138109
    Conserved Domains (2) summary
    cd13310
    Location:300 → 415
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1 → 146
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  6. NM_001357392.1 → NP_001344321.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AC138109
    Conserved Domains (2) summary
    cd13310
    Location:300 → 415
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1 → 146
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  7. NM_023884.4 → NP_076373.3  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform a

    See identical proteins and their annotated locations for NP_076373.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.
    Source sequence(s)
    AC138109, AK019543, AK033549, CJ104104
    Consensus CDS
    CCDS15396.1
    UniProtKB/Swiss-Prot
    Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6
    UniProtKB/TrEMBL
    Q8C134
    Related
    ENSMUSP00000139645.2, ENSMUST00000191605.7
    Conserved Domains (2) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:466 → 581
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    156631736..156767422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243663.2 → XP_030099523.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X3

    Conserved Domains (2) summary
    cd13310
    Location:326 → 441
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1 → 146
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  2. XM_006497033.2 → XP_006497096.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X3

    Conserved Domains (2) summary
    cd13310
    Location:326 → 441
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1 → 146
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  3. XM_030243662.1 → XP_030099522.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X3

    Conserved Domains (2) summary
    cd13310
    Location:326 → 441
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1 → 146
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  4. XM_030243657.1 → XP_030099517.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

    UniProtKB/TrEMBL
    Q8C134
    Conserved Domains (2) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:440 → 555
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  5. XM_030243660.1 → XP_030099520.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

    UniProtKB/TrEMBL
    Q8C134
    Conserved Domains (2) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:440 → 555
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  6. XM_030243669.1 → XP_030099529.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X4

    Conserved Domains (2) summary
    cd13310
    Location:300 → 415
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1 → 146
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  7. XM_030243656.2 → XP_030099516.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

    UniProtKB/TrEMBL
    Q8C134
    Conserved Domains (2) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:440 → 555
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  8. XM_030243664.2 → XP_030099524.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X3

    Conserved Domains (2) summary
    cd13310
    Location:326 → 441
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1 → 146
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  9. XM_030243667.1 → XP_030099527.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X4

    Conserved Domains (2) summary
    cd13310
    Location:300 → 415
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1 → 146
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  10. XM_036154413.1 → XP_036010306.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X5

    Conserved Domains (2) summary
    cd13310
    Location:235 → 350
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1 → 55
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  11. XM_006497029.4 → XP_006497092.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

    See identical proteins and their annotated locations for XP_006497092.1

    UniProtKB/Swiss-Prot
    Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6
    UniProtKB/TrEMBL
    Q8C134
    Conserved Domains (2) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:466 → 581
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  12. XM_006497028.5 → XP_006497091.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

    See identical proteins and their annotated locations for XP_006497091.1

    UniProtKB/Swiss-Prot
    Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6
    UniProtKB/TrEMBL
    Q8C134
    Related
    ENSMUSP00000140342.2, ENSMUST00000188656.7
    Conserved Domains (2) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:466 → 581
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  13. XM_006497032.5 → XP_006497095.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

    See identical proteins and their annotated locations for XP_006497095.1

    UniProtKB/Swiss-Prot
    Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6
    UniProtKB/TrEMBL
    Q8C134
    Conserved Domains (2) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:466 → 581
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  14. XM_006497030.4 → XP_006497093.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

    See identical proteins and their annotated locations for XP_006497093.1

    UniProtKB/Swiss-Prot
    Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6
    UniProtKB/TrEMBL
    Q8C134
    Related
    ENSMUSP00000139618.2, ENSMUST00000185198.7
    Conserved Domains (2) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:466 → 581
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  15. XM_006497031.5 → XP_006497094.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

    See identical proteins and their annotated locations for XP_006497094.1

    UniProtKB/Swiss-Prot
    Q7TPZ6, Q80YA6, Q8BZ37, Q8BZU2, Q9D2Y7, Q9ERD6
    UniProtKB/TrEMBL
    Q8C134
    Conserved Domains (2) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:466 → 581
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

RNA

  1. XR_003947313.2 RNA Sequence

  2. XR_373625.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERD6.2 GenPept UniProtKB/Swiss-Prot:Q9ERD6

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