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Ninl ninein-like [ Mus musculus (house mouse) ]

Gene ID: 78177, updated on 5-Mar-2024

Summary

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Official Symbol
Ninlprovided by MGI
Official Full Name
ninein-likeprovided by MGI
Primary source
MGI:MGI:1925427
See related
Ensembl:ENSMUSG00000068115 AllianceGenome:MGI:1925427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1004; Gm1634; mKIAA0980; 4930519N13Rik
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in microtubule anchoring at centrosome. Predicted to be located in cytosol; intercellular bridge; and microtubule cytoskeleton. Predicted to be active in centrosome. Is expressed in liver left lobe and liver right lobe. Orthologous to human NINL (ninein like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 7.2), CNS E11.5 (RPKM 6.5) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 G3; 2 74.76 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (150776439..150851330, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (150934519..151009411, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene GINS complex subunit 1 Neighboring gene ribosomal protein L41 pseudogene Neighboring gene eukaryotic translation initiation factor 4E-binding protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06020 Neighboring gene STARR-seq mESC enhancer starr_06023 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3410 Neighboring gene N-acetylneuraminic acid phosphatase Neighboring gene STARR-seq mESC enhancer starr_06026 Neighboring gene predicted gene, 22187

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice. Shao S, et al. J Clin Invest, 2010 Feb. PMID 20093778, Free PMC Article
  2. Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Adissu HA, et al. Dis Model Mech, 2014 May. PMID 24652767, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule anchoring at centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ninein-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207204.2 → NP_997087.2  ninein-like protein

    See identical proteins and their annotated locations for NP_997087.2

    Status: VALIDATED

    Source sequence(s)
    BC067071, BU058995, BY302641, BY715392, CO427181
    Consensus CDS
    CCDS50744.1
    UniProtKB/Swiss-Prot
    A2ANB8, Q6NXH6, Q6ZQ12
    Related
    ENSMUSP00000105522.2, ENSMUST00000109896.8
    Conserved Domains (3) summary
    cd00051
    Location:213 → 260
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam10221
    Location:622 → 707
    DUF2151; Cell cycle and development regulator
    pfam13499
    Location:202 → 260
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    150776439..150851330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500406.4 → XP_006500469.1  ninein-like protein isoform X1

    Conserved Domains (4) summary
    PRK13589
    Location:305 → 363
    PRK13589; flagellin A
    COG1196
    Location:622 → 1392
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1085 → 1395
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam13499
    Location:205 → 266
    EF-hand_7; EF-hand domain pair

  2. XM_030252241.1 → XP_030108101.1  ninein-like protein isoform X7

    Conserved Domains (2) summary
    COG1196
    Location:85 → 448
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:765 → 1075
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_030252240.1 → XP_030108100.1  ninein-like protein isoform X6

    Conserved Domains (4) summary
    PRK13589
    Location:248 → 306
    PRK13589; flagellin A
    COG1196
    Location:338 → 1336
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1028 → 1338
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam13499
    Location:11 → 71
    EF-hand_7; EF-hand domain pair

  4. XM_030252239.2 → XP_030108099.1  ninein-like protein isoform X4

    Conserved Domains (3) summary
    COG1196
    Location:584 → 1354
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1047 → 1357
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam13499
    Location:199 → 260
    EF-hand_7; EF-hand domain pair

  5. XM_030252242.2 → XP_030108102.1  ninein-like protein isoform X8

    Conserved Domains (2) summary
    COG1196
    Location:38 → 401
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:718 → 1028
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. XM_030252243.2 → XP_030108103.1  ninein-like protein isoform X9

    Conserved Domains (2) summary
    COG1196
    Location:12 → 343
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:660 → 970
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  7. XM_006500407.4 → XP_006500470.1  ninein-like protein isoform X2

    Conserved Domains (3) summary
    COG1196
    Location:590 → 1360
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1053 → 1363
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam13499
    Location:205 → 266
    EF-hand_7; EF-hand domain pair

  8. XM_006500409.4 → XP_006500472.1  ninein-like protein isoform X5

    Conserved Domains (4) summary
    PRK13589
    Location:254 → 312
    PRK13589; flagellin A
    COG1196
    Location:571 → 1341
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1034 → 1344
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam13499
    Location:17 → 77
    EF-hand_7; EF-hand domain pair

  9. XM_006500408.4 → XP_006500471.1  ninein-like protein isoform X3

    Conserved Domains (3) summary
    PRK13589
    Location:305 → 363
    PRK13589; flagellin A
    TIGR02168
    Location:437 → 1358
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam13499
    Location:205 → 266
    EF-hand_7; EF-hand domain pair

  10. XM_011239847.3 → XP_011238149.1  ninein-like protein isoform X10

    See identical proteins and their annotated locations for XP_011238149.1

    Conserved Domains (1) summary
    TIGR02168
    Location:460 → 770
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQ12.3 GenPept UniProtKB/Swiss-Prot:Q6ZQ12

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