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CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 [ Homo sapiens (human) ]

Gene ID: 781, updated on 3-Apr-2024

Summary

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Official Symbol
CACNA2D1provided by HGNC
Official Full Name
calcium voltage-gated channel auxiliary subunit alpha2delta 1provided by HGNC
Primary source
HGNC:HGNC:1399
See related
Ensembl:ENSG00000153956 MIM:114204; AllianceGenome:HGNC:1399
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CACNA2; CCHL2A; DEE110; CACNL2A; LINC01112; lncRNA-N3
Summary
The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]
Expression
Broad expression in brain (RPKM 8.0), heart (RPKM 5.6) and 21 other tissues See more
Orthologs
mouse all
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Genomic context

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See CACNA2D1 in Genome Data Viewer
Location:
7q21.11
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (81946444..82443956, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (83197632..83695210, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (81575760..82073272, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100128317 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:81252185-81253384 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:81302077-81302610 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_100136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18335 Neighboring gene DEAD-box helicase 43 pseudogene 3 Neighboring gene hepatocyte growth factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26211 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:81487648-81488847 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26212 Neighboring gene CACNA2D1 antisense RNA 1 Neighboring gene uncharacterized LOC124901687 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:81914122-81914773 Neighboring gene uncharacterized LOC107986813 Neighboring gene uncharacterized LOC124901688 Neighboring gene VISTA enhancer hs2419 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:82071535-82072098 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:82100858-82102057 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:82133878-82134458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:82135692-82136192 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:82267896-82268556 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase pseudogene 5 Neighboring gene uncharacterized LOC105375376

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Biallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy. Dahimene S, et al. Brain, 2022 Aug 27. PMID 35293990, Free PMC Article
  2. Calcium Channel Subunit α2δ-1 as a Potential Biomarker Reflecting Illness Severity and Neuroinflammation in Patients with Acute Ischemic Stroke. Xiong X, et al. J Stroke Cerebrovasc Dis, 2021 Aug. PMID 34049015
  3. The α2δ1 subunit of the voltage-gated calcium channel acts as a potential candidate for breast cancer tumor initial cells biomarker. Li M, et al. Cancer Biomark, 2021. PMID 33896833
  4. Calcium channel α2δ1 subunit is a functional marker and therapeutic target for tumor-initiating cells in non-small cell lung cancer. Ma Y, et al. Cell Death Dis, 2021 Mar 11. PMID 33707423, Free PMC Article
  5. Ca(V) α2δ Autoimmune Encephalitis: A Novel Antibody and its Characteristics. Lee ST, et al. Ann Neurol, 2021 Apr. PMID 33415786

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EMC chaperone-CaV structure reveals an ion channel assembly intermediate.
    Title: EMC chaperone-Ca(V) structure reveals an ion channel assembly intermediate.
  2. Biallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy.
    Title: Biallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy.
  3. The alpha2delta1 subunit of the voltage-gated calcium channel acts as a potential candidate for breast cancer tumor initial cells biomarker.
    Title: The α2δ1 subunit of the voltage-gated calcium channel acts as a potential candidate for breast cancer tumor initial cells biomarker.
  4. Calcium channel alpha2delta1 subunit is a functional marker and therapeutic target for tumor-initiating cells in non-small cell lung cancer.
    Title: Calcium channel α2δ1 subunit is a functional marker and therapeutic target for tumor-initiating cells in non-small cell lung cancer.
  5. Calcium Channel Subunit alpha2delta-1 as a Potential Biomarker Reflecting Illness Severity and Neuroinflammation in Patients with Acute Ischemic Stroke.
    Title: Calcium Channel Subunit α2δ-1 as a Potential Biomarker Reflecting Illness Severity and Neuroinflammation in Patients with Acute Ischemic Stroke.
  6. CaV alpha2delta Autoimmune Encephalitis: A Novel Antibody and its Characteristics.
    Title: Ca(V) α2δ Autoimmune Encephalitis: A Novel Antibody and its Characteristics.
  7. MicroRNA-107 inhibits proliferation and invasion of laryngeal squamous cell carcinoma cells by targeting CACNA2D1 in vitro.
    Title: MicroRNA-107 inhibits proliferation and invasion of laryngeal squamous cell carcinoma cells by targeting CACNA2D1 in vitro.
  8. SCLC cells expressing alpha2delta1 demonstrated CSC-like properties, and may contribute to chemoresistance. ERK may play a key role in alpha2delta1-mediated chemoresistance.
    Title: Mechanistic Exploration of Cancer Stem Cell Marker Voltage-Dependent Calcium Channel α2δ1 Subunit-mediated Chemotherapy Resistance in Small-Cell Lung Cancer.
  9. alpha2delta-1-NMDAR complexes in the hypothalamus serve as an important molecular substrate for the interaction between the sympathetic nervous system and the renin-angiotensin system
    Title: α2δ-1 Is Essential for Sympathetic Output and NMDA Receptor Activity Potentiated by Angiotensin II in the Hypothalamus.
  10. REVIEW: recent findings related to maladaptive changes in the dysregulated VGCC alpha2 delta1 subunit (Cav alpha2 delta1 ) with a focus on exploring the mechanisms underlying the contribution of Cav alpha2 delta1 to pain signal transduction
    Title: Injury-induced maladaptation and dysregulation of calcium channel α(2) δ subunit proteins and its contribution to neuropathic pain development.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Developmental and epileptic encephalopathy 110
MedGen: C5774265 OMIM: 620149 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
EBI GWAS Catalog
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
EBI GWAS Catalog
Genetic predictors of medically refractory ulcerative colitis.
EBI GWAS Catalog
Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.
EBI GWAS Catalog
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
EBI GWAS Catalog
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
EBI GWAS Catalog
Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ30478

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated calcium channel activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
contributes_to voltage-gated calcium channel activity involved in bundle of His cell action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to voltage-gated calcium channel activity involved in cardiac muscle cell action potential IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in calcium ion transmembrane transport via high voltage-gated calcium channel ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium ion transport into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in cardiac muscle cell action potential involved in contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in membrane depolarization during bundle of His cell action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of high voltage-gated calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of heart rate by cardiac conduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of membrane repolarization during action potential ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of L-type voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of L-type voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in neuronal dense core vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
voltage-dependent calcium channel subunit alpha-2/delta-1
Names
alpha2delta-1
calcium channel, L type, alpha 2 polypeptide
calcium channel, voltage-dependent, alpha 2/delta subunit 1
dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit
voltage-gated calcium channel subunit alpha-2/delta-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009358.2 RefSeqGene

    Range
    4910..502272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_437

mRNA and Protein(s)

  1. NM_000722.4 → NP_000713.2  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_000713.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC006145, AI924415, AL707206, AL833141, BC051339, BG055272, BP258070, M76559
    Consensus CDS
    CCDS5598.1
    UniProtKB/TrEMBL
    A0A994J595
    Related
    ENSP00000349320.3, ENST00000356860.8
    Conserved Domains (5) summary
    cd01463
    Location:239 → 417
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:446 → 531
    Cache_1; Cache domain
    pfam08399
    Location:104 → 223
    VWA_N; VWA N-terminal
    pfam08473
    Location:543 → 627
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cl21471
    Location:636 → 816
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein

  2. NM_001302890.2 → NP_001289819.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons and contains an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. This isoform lacks the entire delta chain and a large portion of the alpha-2 chain.
    Source sequence(s)
    BC051339, BP258070
    Consensus CDS
    CCDS78253.1
    UniProtKB/TrEMBL
    E7ERK3
    Related
    ENSP00000405395.1, ENST00000423588.1
    Conserved Domains (2) summary
    pfam08399
    Location:104 → 223
    VWA_N; VWA N-terminal
    cl00057
    Location:239 → 300
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. NM_001366867.1 → NP_001353796.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 3 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC004970, AC004989, AC006145, AC008283
    Consensus CDS
    CCDS94135.1
    UniProtKB/Swiss-Prot
    P54289, Q17R45, Q9UD80, Q9UD81, Q9UD82
    UniProtKB/TrEMBL
    A0A994J595
    Related
    ENSP00000409374.2, ENST00000443883.2
    Conserved Domains (4) summary
    cd01463
    Location:239 → 417
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:425 → 530
    dCache_1; Cache domain
    pfam08399
    Location:104 → 223
    VWA_N; VWA N-terminal
    pfam08473
    Location:645 → 1072
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    81946444..82443956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250574.4 → XP_005250631.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X10

    UniProtKB/TrEMBL
    A0A994J595
    Related
    ENSP00000516190.1, ENST00000705962.1
    Conserved Domains (5) summary
    cd01463
    Location:239 → 417
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:446 → 530
    Cache_1; Cache domain
    pfam08399
    Location:104 → 223
    VWA_N; VWA N-terminal
    pfam08473
    Location:538 → 622
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cl21471
    Location:537 → 804
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein

  2. XM_005250572.4 → XP_005250629.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X6

    UniProtKB/TrEMBL
    A0A994J595
    Conserved Domains (5) summary
    cd01463
    Location:239 → 417
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:446 → 530
    Cache_1; Cache domain
    pfam08399
    Location:104 → 223
    VWA_N; VWA N-terminal
    pfam08473
    Location:538 → 622
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cl21471
    Location:631 → 811
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein

  3. XM_005250573.4 → XP_005250630.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X8

    UniProtKB/TrEMBL
    A0A994J595
    Conserved Domains (5) summary
    cd01463
    Location:239 → 417
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:446 → 531
    Cache_1; Cache domain
    pfam08399
    Location:104 → 223
    VWA_N; VWA N-terminal
    pfam08473
    Location:543 → 627
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cl21471
    Location:542 → 809
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein

  4. XM_011516572.4 → XP_011514874.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X5

    UniProtKB/TrEMBL
    A0A994J595
    Conserved Domains (5) summary
    cd01463
    Location:239 → 417
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:446 → 536
    Cache_1; Cache domain
    pfam08399
    Location:104 → 223
    VWA_N; VWA N-terminal
    pfam08473
    Location:557 → 641
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cl21471
    Location:556 → 823
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein

  5. XM_011516571.4 → XP_011514873.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X3

    UniProtKB/TrEMBL
    A0A994J595
    Conserved Domains (5) summary
    cd01463
    Location:239 → 417
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:446 → 536
    Cache_1; Cache domain
    pfam08399
    Location:104 → 223
    VWA_N; VWA N-terminal
    pfam08473
    Location:557 → 641
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cl21471
    Location:650 → 830
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein

  6. XM_006716118.4 → XP_006716181.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1

    See identical proteins and their annotated locations for XP_006716181.1

    UniProtKB/TrEMBL
    A0A994J595, Q9UIU0
    Conserved Domains (5) summary
    cd01463
    Location:239 → 417
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:446 → 536
    Cache_1; Cache domain
    pfam08399
    Location:104 → 223
    VWA_N; VWA N-terminal
    pfam08473
    Location:562 → 646
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cl21471
    Location:655 → 835
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein

  7. XM_006716120.4 → XP_006716183.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X12

    UniProtKB/TrEMBL
    A0A994J595
    Related
    ENSP00000516189.1, ENST00000705961.1
    Conserved Domains (4) summary
    cd01463
    Location:200 → 378
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:407 → 497
    Cache_1; Cache domain
    pfam08399
    Location:65 → 184
    VWA_N; VWA N-terminal
    pfam08473
    Location:523 → 607
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

  8. XM_006716121.3 → XP_006716184.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X13

    Conserved Domains (2) summary
    pfam08473
    Location:32 → 116
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cl21471
    Location:125 → 305
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein

  9. XM_047420822.1 → XP_047276778.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X11

  10. XM_047420820.1 → XP_047276776.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X7

  11. XM_047420821.1 → XP_047276777.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X9

  12. XM_047420819.1 → XP_047276775.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X4

  13. XM_011516570.4 → XP_011514872.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X2

    UniProtKB/TrEMBL
    A0A994J595
    Conserved Domains (5) summary
    cd01463
    Location:239 → 417
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:446 → 536
    Cache_1; Cache domain
    pfam08399
    Location:104 → 223
    VWA_N; VWA N-terminal
    pfam08473
    Location:562 → 646
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cl21471
    Location:655 → 835
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein

RNA

  1. XR_001744873.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    83197632..83695210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358980.1 → XP_054214955.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X10

  2. XM_054358975.1 → XP_054214950.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X6

  3. XM_054358978.1 → XP_054214953.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X8

  4. XM_054358974.1 → XP_054214949.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X5

  5. XM_054358972.1 → XP_054214947.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X3

  6. XM_054358970.1 → XP_054214945.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1

    UniProtKB/TrEMBL
    Q9UIU0

  7. XM_054358982.1 → XP_054214957.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X12

  8. XM_054358977.1 → XP_054214952.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X14

  9. XM_054358983.1 → XP_054214958.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X13

  10. XM_054358981.1 → XP_054214956.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X11

  11. XM_054358976.1 → XP_054214951.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X7

  12. XM_054358973.1 → XP_054214948.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X4

  13. XM_054358971.1 → XP_054214946.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X2

  14. XM_054358979.1 → XP_054214954.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X9

RNA

  1. XR_008487750.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54289.3 GenPept UniProtKB/Swiss-Prot:P54289

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