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Tchp trichoplein, keratin filament binding [ Mus musculus (house mouse) ]

Gene ID: 77832, updated on 5-Mar-2024

Summary

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Official Symbol
Tchpprovided by MGI
Official Full Name
trichoplein, keratin filament bindingprovided by MGI
Primary source
MGI:MGI:1925082
See related
Ensembl:ENSMUSG00000002486 AllianceGenome:MGI:1925082
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A930031F18Rik
Summary
Predicted to be involved in apoptotic process; negative regulation of cell growth; and negative regulation of cilium assembly. Predicted to act upstream of or within cell projection organization. Located in desmosome and keratin filament. Part of ciliary transition fiber. Is expressed in inner ear and olfactory epithelium. Orthologous to human TCHP (trichoplein keratin filament binding). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 22.2), CNS E11.5 (RPKM 10.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Tchp in Genome Data Viewer
Location:
5 F; 5 55.99 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (114845813..114860388)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114707779..114722327)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2757 Neighboring gene transient receptor potential cation channel, subfamily V, member 4 Neighboring gene STARR-positive B cell enhancer ABC_E9261 Neighboring gene STARR-seq mESC enhancer starr_14082 Neighboring gene glycolipid transfer protein Neighboring gene STARR-positive B cell enhancer ABC_E10341 Neighboring gene predicted gene, 34931 Neighboring gene microRNA 7028 Neighboring gene GIT ArfGAP 2 Neighboring gene RIKEN cDNA 4930515G01 gene Neighboring gene STARR-positive B cell enhancer ABC_E3602 Neighboring gene STARR-positive B cell enhancer ABC_E3603 Neighboring gene ankyrin repeat domain 13a Neighboring gene STARR-seq mESC enhancer starr_14089

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis. Yamakawa D, et al. Cell Rep, 2021 Mar 9. PMID 33691104
  2. Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy. Martello A, et al. EMBO Rep, 2020 Jul 3. PMID 32337819, Free PMC Article
  3. Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells. Fassan M, et al. PLoS One, 2011 May 6. PMID 21573075, Free PMC Article
  4. Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. Ibi M, et al. J Cell Sci, 2011 Mar 15. PMID 21325031
  5. Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway. Inaba H, et al. J Cell Biol, 2016 Feb 15. PMID 26880200, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ndel1 acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly.
    Title: Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.
  2. MITOSTATIN may acts as a tumor suppressor gene in prostate cancer.
    Title: Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical cortex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
part_of ciliary transition fiber IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in desmosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in keratin filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in keratin filament ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
trichoplein keratin filament-binding protein
Names
mitochondrial protein with oncostatic activity
mitostatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029992.2 → NP_084268.2  trichoplein keratin filament-binding protein

    See identical proteins and their annotated locations for NP_084268.2

    Status: VALIDATED

    Source sequence(s)
    AK020912, AK159947, BC043048, BU512279
    Consensus CDS
    CCDS51624.1
    UniProtKB/Swiss-Prot
    Q3TVW5, Q80ZV6, Q8C459, Q9CTP0
    Related
    ENSMUSP00000092009.5, ENSMUST00000094441.11
    Conserved Domains (1) summary
    pfam13868
    Location:145 → 479
    TPH; Trichohyalin-plectin-homology domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    114845813..114860388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530508.4 → XP_006530571.1  trichoplein keratin filament-binding protein isoform X1

    Conserved Domains (1) summary
    pfam13868
    Location:83 → 420
    TPH; Trichohyalin-plectin-homology domain

  2. XM_036165613.1 → XP_036021506.1  trichoplein keratin filament-binding protein isoform X3

    Conserved Domains (1) summary
    pfam13868
    Location:4 → 223
    TPH; Trichohyalin-plectin-homology domain

  3. XM_006530510.5 → XP_006530573.1  trichoplein keratin filament-binding protein isoform X3

    See identical proteins and their annotated locations for XP_006530573.1

    UniProtKB/Swiss-Prot
    Q3TVW5
    Conserved Domains (1) summary
    pfam13868
    Location:4 → 223
    TPH; Trichohyalin-plectin-homology domain

  4. XM_006530511.5 → XP_006530574.1  trichoplein keratin filament-binding protein isoform X2

    Conserved Domains (1) summary
    pfam13868
    Location:1 → 282
    TPH; Trichohyalin-plectin-homology domain

RNA

  1. XR_004942586.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TVW5.2 GenPept UniProtKB/Swiss-Prot:Q3TVW5

Gene LinkOut

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