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Krba1 KRAB-A domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 77827, updated on 5-Mar-2024

Summary

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Official Symbol
Krba1provided by MGI
Official Full Name
KRAB-A domain containing 1provided by MGI
Primary source
MGI:MGI:1925077
See related
Ensembl:ENSMUSG00000042810 AllianceGenome:MGI:1925077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A930040G15Rik
Summary
Is expressed in several structures, including early conceptus; genitourinary system; and nervous system. Orthologous to human KRBA1 (KRAB-A domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 12.2), adrenal adult (RPKM 11.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B2.3; 6 23.36 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48371577..48396789)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48394643..48419855)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 16630 Neighboring gene nuclear encoded tRNA cysteine 19 (anticodon GCA) Neighboring gene retinol dehydrogenase 11 pseudogene Neighboring gene predicted gene, 38803 Neighboring gene predicted gene, 57777 Neighboring gene zinc finger protein 467

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
protein KRBA1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347152.1 → NP_001334081.1  protein KRBA1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC153815
    Consensus CDS
    CCDS85037.1
    UniProtKB/TrEMBL
    A0A140T8R3
    Related
    ENSMUSP00000110219.5, ENSMUST00000114572.9

  2. NM_001347153.1 → NP_001334082.1  protein KRBA1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The first difference causes translation initiation at a downstream AUG; the resulting isoform (3) is shorter at the N-terminus and lacks an alternate internal aa compared to isoform 1.
    Source sequence(s)
    AC153815
    Consensus CDS
    CCDS85038.1
    UniProtKB/TrEMBL
    A0A0N4SVV3
    Related
    ENSMUSP00000145256.2, ENSMUST00000203371.3
    Conserved Domains (2) summary
    PTZ00449
    Location:701 → 818
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15287
    Location:193 → 235
    KRBA1; KRBA1 family repeat

  3. NM_001362144.1 → NP_001349073.1  protein KRBA1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction in the 5' end compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1. Variants 2 and 4 both encode the same isoform (2).
    Source sequence(s)
    AC153815
    Consensus CDS
    CCDS20102.1
    UniProtKB/Swiss-Prot
    E9QNG7, Q69Z85, Q6NXZ1, Q9JJG3
    Related
    ENSMUSP00000076345.6, ENSMUST00000077093.7
    Conserved Domains (2) summary
    pfam15287
    Location:194 → 236
    KRBA1; KRBA1 family repeat
    cl25751
    Location:702 → 819
    DUF4045; Domain of unknown function (DUF4045)

  4. NM_001362145.1 → NP_001349074.1  protein KRBA1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has a longer and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AB041543, AC153815
    Consensus CDS
    CCDS90043.1
    Related
    ENSMUSP00000031815.6, ENSMUST00000031815.12
    Conserved Domains (2) summary
    pfam15287
    Location:249 → 291
    KRBA1; KRBA1 family repeat
    cl25751
    Location:691 → 808
    DUF4045; Domain of unknown function (DUF4045)

  5. NM_133922.3 → NP_598683.3  protein KRBA1 isoform 2

    See identical proteins and their annotated locations for NP_598683.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1. Variants 2 and 4 both encode the same isoform (2).
    Source sequence(s)
    AC153815, AK040525
    Consensus CDS
    CCDS20102.1
    UniProtKB/Swiss-Prot
    E9QNG7, Q69Z85, Q6NXZ1, Q9JJG3
    Related
    ENSMUSP00000110218.3, ENSMUST00000114571.8
    Conserved Domains (2) summary
    pfam15287
    Location:194 → 236
    KRBA1; KRBA1 family repeat
    cl25751
    Location:702 → 819
    DUF4045; Domain of unknown function (DUF4045)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    48371577..48396789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506757.5 → XP_006506820.1  protein KRBA1 isoform X1

    Conserved Domains (2) summary
    PTZ00449
    Location:763 → 880
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15287
    Location:250 → 292
    KRBA1; KRBA1 family repeat

  2. XM_006506759.5 → XP_006506822.1  protein KRBA1 isoform X3

    Conserved Domains (2) summary
    PTZ00449
    Location:758 → 875
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15287
    Location:250 → 292
    KRBA1; KRBA1 family repeat

  3. XM_006506766.5 → XP_006506829.1  protein KRBA1 isoform X9

    Conserved Domains (2) summary
    PTZ00449
    Location:697 → 814
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15287
    Location:250 → 292
    KRBA1; KRBA1 family repeat

  4. XM_006506767.5 → XP_006506830.1  protein KRBA1 isoform X10

    Conserved Domains (2) summary
    PTZ00449
    Location:692 → 809
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15287
    Location:250 → 292
    KRBA1; KRBA1 family repeat

  5. XM_006506758.5 → XP_006506821.1  protein KRBA1 isoform X2

    Conserved Domains (2) summary
    PTZ00449
    Location:762 → 879
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15287
    Location:249 → 291
    KRBA1; KRBA1 family repeat

  6. XM_030255674.2 → XP_030111534.1  protein KRBA1 isoform X13

    Conserved Domains (2) summary
    PTZ00449
    Location:257 → 374
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15287
    Location:48 → 69
    KRBA1; KRBA1 family repeat

  7. XM_006506763.5 → XP_006506826.1  protein KRBA1 isoform X6

    See identical proteins and their annotated locations for XP_006506826.1

    Conserved Domains (2) summary
    PTZ00449
    Location:707 → 824
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15287
    Location:194 → 236
    KRBA1; KRBA1 family repeat

  8. XM_030255672.2 → XP_030111532.1  protein KRBA1 isoform X11

    Conserved Domains (2) summary
    PTZ00449
    Location:636 → 753
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15287
    Location:194 → 236
    KRBA1; KRBA1 family repeat

  9. XM_030255671.2 → XP_030111531.1  protein KRBA1 isoform X7

    Conserved Domains (2) summary
    PTZ00449
    Location:706 → 823
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15287
    Location:193 → 235
    KRBA1; KRBA1 family repeat

  10. XM_006506760.5 → XP_006506823.1  protein KRBA1 isoform X4

    Conserved Domains (3) summary
    PTZ00449
    Location:742 → 859
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam01352
    Location:6 → 47
    KRAB; KRAB box
    pfam15287
    Location:229 → 271
    KRBA1; KRBA1 family repeat

  11. XM_017321832.3 → XP_017177321.1  protein KRBA1 isoform X12

    Conserved Domains (2) summary
    PTZ00449
    Location:395 → 512
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15287
    Location:61 → 103
    KRBA1; KRBA1 family repeat

  12. XM_036152396.1 → XP_036008289.1  protein KRBA1 isoform X11

    Conserved Domains (2) summary
    PTZ00449
    Location:636 → 753
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15287
    Location:194 → 236
    KRBA1; KRBA1 family repeat

  13. XM_030255670.2 → XP_030111530.1  protein KRBA1 isoform X5

    Conserved Domains (3) summary
    PTZ00449
    Location:736 → 853
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam01352
    Location:6 → 47
    KRAB; KRAB box
    pfam15287
    Location:228 → 270
    KRBA1; KRBA1 family repeat

  14. XM_006506762.5 → XP_006506825.1  protein KRBA1 isoform X6

    See identical proteins and their annotated locations for XP_006506825.1

    Conserved Domains (2) summary
    PTZ00449
    Location:707 → 824
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15287
    Location:194 → 236
    KRBA1; KRBA1 family repeat

  15. XM_036152397.1 → XP_036008290.1  protein KRBA1 isoform X13

    Conserved Domains (2) summary
    PTZ00449
    Location:257 → 374
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15287
    Location:48 → 69
    KRBA1; KRBA1 family repeat

  16. XM_036152395.1 → XP_036008288.1  protein KRBA1 isoform X8

    UniProtKB/TrEMBL
    A0A0N4SVV3
    Conserved Domains (2) summary
    PTZ00449
    Location:701 → 818
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15287
    Location:193 → 235
    KRBA1; KRBA1 family repeat

  17. XM_036152398.1 → XP_036008291.1  protein KRBA1 isoform X13

    Conserved Domains (2) summary
    PTZ00449
    Location:257 → 374
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam15287
    Location:48 → 69
    KRBA1; KRBA1 family repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NXZ1.2 GenPept UniProtKB/Swiss-Prot:Q6NXZ1

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