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Esco1 establishment of sister chromatid cohesion N-acetyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 77805, updated on 11-Apr-2024

Summary

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Official Symbol
Esco1provided by MGI
Official Full Name
establishment of sister chromatid cohesion N-acetyltransferase 1provided by MGI
Primary source
MGI:MGI:1925055
See related
Ensembl:ENSMUSG00000024293 AllianceGenome:MGI:1925055
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A930014I12Rik
Summary
Predicted to enable identical protein binding activity; peptide-lysine-N-acetyltransferase activity; and zinc ion binding activity. Predicted to be involved in protein acetylation; regulation of DNA replication; and sister chromatid cohesion. Predicted to be located in chromatin. Is expressed in gonad; reproductive system; and urinary system. Orthologous to human ESCO1 (establishment of sister chromatid cohesion N-acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 3.4), bladder adult (RPKM 2.6) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Esco1 in Genome Data Viewer
Location:
18 A1; 18 5.21 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (10566507..10610863, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (10566507..10610863, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43791 Neighboring gene STARR-seq mESC enhancer starr_43793 Neighboring gene RAE1 RNA export 1 homolog pseudogene Neighboring gene growth regulation by estrogen in breast cancer-like Neighboring gene nuclear transport factor 2, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_43798 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:10532920-10533103 Neighboring gene small nuclear ribonucleoprotein D1 Neighboring gene abhydrolase domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The cohesion establishment factor Esco1 acetylates α-tubulin to ensure proper spindle assembly in oocyte meiosis. Lu Y, et al. Nucleic Acids Res, 2018 Mar 16. PMID 29361031, Free PMC Article
  2. Alternative catalytic residues in the active site of Esco acetyltransferases. Ajam T, et al. Sci Rep, 2020 Jun 17. PMID 32555289, Free PMC Article
  3. Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex. Ulmke PA, et al. Stem Cell Reports, 2021 Apr 13. PMID 33798452, Free PMC Article
  4. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Alternative catalytic residues in the active site of Esco acetyltransferases.
    Title: Alternative catalytic residues in the active site of Esco acetyltransferases.
  2. Esco1 is required for alpha-tubulin acetylation and microtubule stability, which thereby ensures normal spindle assembly and proper chromosome alignment to orchestrate the mouse oocyte meiotic progression.
    Title: The cohesion establishment factor Esco1 acetylates α-tubulin to ensure proper spindle assembly in oocyte meiosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide-lysine-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-lysine-N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in post-translational protein acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
N-acetyltransferase ESCO1
Names
ECO1 homolog 1
establishment of cohesion 1 homolog 1
establisment of cohesion 1 homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081222.1 → NP_001074691.1  N-acetyltransferase ESCO1

    See identical proteins and their annotated locations for NP_001074691.1

    Status: PROVISIONAL

    Source sequence(s)
    AC102441, AC105947
    Consensus CDS
    CCDS37737.1
    UniProtKB/Swiss-Prot
    B9EKQ9, Q69Z69, Q8BQI2, Q8BR47, Q922F5
    UniProtKB/TrEMBL
    Q3ULS5
    Related
    ENSMUSP00000025142.6, ENSMUST00000025142.13
    Conserved Domains (2) summary
    pfam13878
    Location:607 → 646
    zf-C2H2_3; zinc-finger of acetyl-transferase ESCO
    pfam13880
    Location:766 → 828
    Acetyltransf_13; ESCO1/2 acetyl-transferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    10566507..10610863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526353.4 → XP_006526416.1  N-acetyltransferase ESCO1 isoform X1

    See identical proteins and their annotated locations for XP_006526416.1

    UniProtKB/TrEMBL
    Q3UKT9
    Related
    ENSMUSP00000095274.4, ENSMUST00000097670.10
    Conserved Domains (2) summary
    pfam13878
    Location:108 → 147
    zf-C2H2_3; zinc-finger of acetyl-transferase ESCO
    pfam13880
    Location:267 → 335
    Acetyltransf_13; ESCO1/2 acetyl-transferase

  2. XM_036161309.1 → XP_036017202.1  N-acetyltransferase ESCO1 isoform X2

    Related
    ENSMUSP00000111530.2, ENSMUST00000115864.8
    Conserved Domains (2) summary
    pfam13878
    Location:83 → 122
    zf-C2H2_3; zinc-finger of acetyl-transferase ESCO
    pfam13880
    Location:242 → 310
    Acetyltransf_13; ESCO1/2 acetyl-transferase

RNA

  1. XR_003952544.1 RNA Sequence

    Related
    ENSMUST00000127099.9

  2. XR_001782403.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144542.1: Suppressed sequence

    Description
    NM_144542.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69Z69.2 GenPept UniProtKB/Swiss-Prot:Q69Z69

Gene LinkOut

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