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Sla2 Src-like-adaptor 2 [ Mus musculus (house mouse) ]

Gene ID: 77799, updated on 5-Mar-2024

Summary

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Official Symbol
Sla2provided by MGI
Official Full Name
Src-like-adaptor 2provided by MGI
Primary source
MGI:MGI:1925049
See related
Ensembl:ENSMUSG00000027636 AllianceGenome:MGI:1925049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SLAP2; SLAP-2; A930009E21Rik
Summary
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity; protein N-terminus binding activity; and signaling adaptor activity. Acts upstream of or within T cell activation. Located in late endosome and plasma membrane. Is expressed in thymus primordium. Orthologous to human SLA2 (Src like adaptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 36.8), placenta adult (RPKM 10.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H1; 2 77.89 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156716071..156729161, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156874151..156887250, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene TGFB-induced factor homeobox 2 Neighboring gene RIKEN cDNA 5430405H02 gene Neighboring gene STARR-positive B cell enhancer ABC_E1606 Neighboring gene RAB5 interacting factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156712828-156713029 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06191 Neighboring gene STARR-seq mESC enhancer starr_06192 Neighboring gene N-myc downstream regulated gene 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation. Liontos LM, et al. J Immunol, 2011 Feb 15. PMID 21220694
  2. Sleuthing biochemical evidence to elucidate unassigned electron density in a CBL-SLAP2 crystal complex. Wybenga-Groot LE, et al. Acta Crystallogr F Struct Biol Commun, 2021 Feb 1. PMID 33620036, Free PMC Article
  3. Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling. Moharram SA, et al. Oncotarget, 2016 Sep 6. PMID 27458164, Free PMC Article
  4. SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice. Cherpokova D, et al. Blood, 2015 Jan 1. PMID 25301707, Free PMC Article
  5. Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v. Loreto MP, et al. Oncogene, 2003 Jan 16. PMID 12527895

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sleuthing biochemical evidence to elucidate unassigned electron density in a CBL-SLAP2 crystal complex.
    Title: Sleuthing biochemical evidence to elucidate unassigned electron density in a CBL-SLAP2 crystal complex.
  2. SLAP2 acts as a negative regulator of FLT3 signaling and therefore, modulation of SLAP2 expression levels may provide an alternative therapeutic approach for FLT3-ITD positive acute myeloid leukemia
    Title: Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling.
  3. SLAP and SLAP2 are critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke
    Title: SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice.
  4. In bone marrow-derived dendritic cells lacking SLAP and closely related SLAP2, downregulation of the granulocyte-macrophage colony-stimulating factor (GM-CSF)beta receptor is impaired.
    Title: The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation.
  5. SLAP-2 plays a role in c-Cbl-dependent down-regulation of CSF-1R signaling
    Title: The Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of T cell activation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
src-like-adapter 2
Names
modulator of antigen receptor signaling MARS
src-like adapter protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356495.1 → NP_001343424.1  src-like-adapter 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL935150, BC052655
    Consensus CDS
    CCDS38302.1
    UniProtKB/Swiss-Prot
    Q3UU74, Q8C0K2, Q8R4L0, Q8VI42, Q9D1Z9
    UniProtKB/TrEMBL
    Q7TMX7
    Related
    ENSMUSP00000105189.4, ENSMUST00000109561.4
    Conserved Domains (2) summary
    cd10344
    Location:82 → 185
    SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins
    cl17036
    Location:35 → 89
    SH3; Src Homology 3 domain superfamily

  2. NM_029983.6 → NP_084259.1  src-like-adapter 2

    See identical proteins and their annotated locations for NP_084259.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK138709, AL935150
    Consensus CDS
    CCDS38302.1
    UniProtKB/Swiss-Prot
    Q3UU74, Q8C0K2, Q8R4L0, Q8VI42, Q9D1Z9
    UniProtKB/TrEMBL
    Q7TMX7
    Related
    ENSMUSP00000029164.3, ENSMUST00000029164.9
    Conserved Domains (2) summary
    cd10344
    Location:82 → 185
    SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins
    cl17036
    Location:35 → 89
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    156716071..156729161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239846.1 → XP_011238148.1  src-like-adapter 2 isoform X1

    See identical proteins and their annotated locations for XP_011238148.1

    UniProtKB/TrEMBL
    Q7TMX7
    Conserved Domains (2) summary
    cl15255
    Location:82 → 200
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:35 → 89
    SH3; Src Homology 3 domain superfamily

  2. XM_011239845.3 → XP_011238147.1  src-like-adapter 2 isoform X1

    See identical proteins and their annotated locations for XP_011238147.1

    UniProtKB/TrEMBL
    Q7TMX7
    Conserved Domains (2) summary
    cl15255
    Location:82 → 200
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:35 → 89
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4L0.3 GenPept UniProtKB/Swiss-Prot:Q8R4L0

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