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Csrnp3 cysteine-serine-rich nuclear protein 3 [ Mus musculus (house mouse) ]

Gene ID: 77771, updated on 5-Mar-2024

Summary

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Official Symbol
Csrnp3provided by MGI
Official Full Name
cysteine-serine-rich nuclear protein 3provided by MGI
Primary source
MGI:MGI:1925021
See related
Ensembl:ENSMUSG00000044647 AllianceGenome:MGI:1925021
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mbu1; Csnrp3; taip-2; CSRNP-3; A330102K23Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of apoptotic process and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; gonad; intestine; liver; and lung. Orthologous to human CSRNP3 (cysteine and serine rich nuclear protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 9.1), whole brain E14.5 (RPKM 8.2) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C1.3; 2 38.79 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (65675628..65866958)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (65845284..66036614)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm777 Neighboring gene sodium channel, voltage-gated, type II, alpha Neighboring gene STARR-seq mESC enhancer starr_04691 Neighboring gene STARR-seq mESC enhancer starr_04692 Neighboring gene STARR-seq mESC enhancer starr_04693 Neighboring gene predicted gene, 51432 Neighboring gene predicted gene, 52514 Neighboring gene STARR-seq mESC enhancer starr_04694 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 3 Neighboring gene STARR-seq mESC enhancer starr_04695 Neighboring gene tetratricopeptide repeat domain 21B Neighboring gene STARR-positive B cell enhancer mm9_chr2:66094546-66094847

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential promoter methylation and histone modification contribute to the brain specific expression of the mouse Mbu-1 gene. Kim B, et al. Mol Cells, 2012 Nov. PMID 23076708, Free PMC Article
  2. Characterization of a novel mouse brain gene (mbu-1) identified by digital differential display. Yang HL, et al. Gene, 2007 Jun 15. PMID 17433858
  3. Taip2 is a novel cell death-related gene expressed in the brain during development. Yamada K, et al. Biochem Biophys Res Commun, 2008 May 2. PMID 18291095
  4. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). Gingras S, et al. PLoS One, 2007 Aug 29. PMID 17726538, Free PMC Article
  5. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CpG methylation converses with histone modifications in an opposing sense of regulating Mbu-1 expression
    Title: Differential promoter methylation and histone modification contribute to the brain specific expression of the mouse Mbu-1 gene.
  2. the mbu-1 gene was only expressed in the brain and spinal cord during the embryonic stages, and throughout all regions of the adult brain, showing higher levels in the hippocampus and hypothalamus
    Title: Characterization of a novel mouse brain gene (mbu-1) identified by digital differential display.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cysteine/serine-rich nuclear protein 3
Names
TGF-beta induced apoptosis protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290665.1 → NP_001277594.1  cysteine/serine-rich nuclear protein 3 isoform b

    See identical proteins and their annotated locations for NP_001277594.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK158873, AL929230, AW492062
    Consensus CDS
    CCDS71060.1
    UniProtKB/Swiss-Prot
    P59055
    Related
    ENSMUSP00000135605.2, ENSMUST00000145598.9
    Conserved Domains (1) summary
    pfam16019
    Location:61 → 278
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

  2. NM_001290666.1 → NP_001277595.1  cysteine/serine-rich nuclear protein 3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons, and it thus differs in its 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AL929230, AW492062, BC055701, BY297754
    UniProtKB/TrEMBL
    Q7TNU4
    Conserved Domains (2) summary
    pfam16019
    Location:35 → 180
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    cl00310
    Location:371 → 416
    AIRC; AIR carboxylase

  3. NM_153409.5 → NP_700458.3  cysteine/serine-rich nuclear protein 3 isoform a

    See identical proteins and their annotated locations for NP_700458.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode isoform a.
    Source sequence(s)
    AK039150, AL929230, BY297754, EF210820
    Consensus CDS
    CCDS16074.2
    UniProtKB/Swiss-Prot
    A3F6Q4, P59055, Q8BUT9, Q8BYL1
    Related
    ENSMUSP00000117533.2, ENSMUST00000122912.8
    Conserved Domains (1) summary
    pfam16019
    Location:73 → 290
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

  4. NM_178634.2 → NP_848749.2  cysteine/serine-rich nuclear protein 3 isoform a

    See identical proteins and their annotated locations for NP_848749.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AK082649, AL929230, BY297754, EF210820
    Consensus CDS
    CCDS16074.2
    UniProtKB/Swiss-Prot
    A3F6Q4, P59055, Q8BUT9, Q8BYL1
    Related
    ENSMUSP00000055719.4, ENSMUST00000053910.10
    Conserved Domains (1) summary
    pfam16019
    Location:73 → 290
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    65675628..65866958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252233.1 → XP_030108093.1  cysteine/serine-rich nuclear protein 3 isoform X1

    UniProtKB/Swiss-Prot
    A3F6Q4, P59055, Q8BUT9, Q8BYL1
    Conserved Domains (1) summary
    pfam16019
    Location:73 → 290
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

  2. XM_030252234.1 → XP_030108094.1  cysteine/serine-rich nuclear protein 3 isoform X1

    UniProtKB/Swiss-Prot
    A3F6Q4, P59055, Q8BUT9, Q8BYL1
    Conserved Domains (1) summary
    pfam16019
    Location:73 → 290
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

  3. XM_030252235.1 → XP_030108095.1  cysteine/serine-rich nuclear protein 3 isoform X2

    Conserved Domains (1) summary
    pfam16019
    Location:61 → 278
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

  4. XM_036162720.1 → XP_036018613.1  cysteine/serine-rich nuclear protein 3 isoform X2

    Conserved Domains (1) summary
    pfam16019
    Location:61 → 278
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

  5. XM_030252237.1 → XP_030108097.1  cysteine/serine-rich nuclear protein 3 isoform X2

    Conserved Domains (1) summary
    pfam16019
    Location:61 → 278
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

  6. XM_030252236.1 → XP_030108096.1  cysteine/serine-rich nuclear protein 3 isoform X2

    Conserved Domains (1) summary
    pfam16019
    Location:61 → 278
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59055.2 GenPept UniProtKB/Swiss-Prot:P59055

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