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ZNF225 zinc finger protein 225 [ Homo sapiens (human) ]

Gene ID: 7768, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF225provided by HGNC
Official Full Name
zinc finger protein 225provided by HGNC
Primary source
HGNC:HGNC:13018
See related
Ensembl:ENSG00000256294 AllianceGenome:HGNC:13018
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 1.5), testis (RPKM 1.4) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.31
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44111425..44134822)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46934319..46957717)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44617552..44638975)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 284 Neighboring gene RNA, U6 small nuclear 902, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14752 Neighboring gene zinc finger protein 224 Neighboring gene ZNF225 and ZNF224 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:44617263-44617613 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44645889-44646479 Neighboring gene zinc finger protein 234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14757 Neighboring gene zinc finger protein 226

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
  2. USP45 and Spindly are part of the same complex implicated in cell migration. Conte C, et al. Sci Rep, 2018 Sep 26. PMID 30258100, Free PMC Article
  3. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824
  4. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Dias Neto E, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737800, Free PMC Article
  5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC119735

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321685.2 → NP_001308614.1  zinc finger protein 225

    Status: VALIDATED

    Source sequence(s)
    AC021092, BU633034, EG328378
    Consensus CDS
    CCDS46100.1
    UniProtKB/Swiss-Prot
    A8K8S2, Q53F12, Q9NS46, Q9UID8, Q9UK10
    Conserved Domains (3) summary
    COG5048
    Location:202 → 634
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:458 → 478
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 48
    KRAB; KRAB box

  2. NM_013362.4 → NP_037494.2  zinc finger protein 225

    See identical proteins and their annotated locations for NP_037494.2

    Status: VALIDATED

    Source sequence(s)
    AC021092, AK223477, BQ373092, BU633034, EG328378
    Consensus CDS
    CCDS46100.1
    UniProtKB/Swiss-Prot
    A8K8S2, Q53F12, Q9NS46, Q9UID8, Q9UK10
    Related
    ENSP00000262894.5, ENST00000262894.11
    Conserved Domains (3) summary
    COG5048
    Location:202 → 634
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:458 → 478
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 48
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    44111425..44134822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527286.3 → XP_011525588.1  zinc finger protein 225 isoform X1

    See identical proteins and their annotated locations for XP_011525588.1

    UniProtKB/Swiss-Prot
    A8K8S2, Q53F12, Q9NS46, Q9UID8, Q9UK10
    Conserved Domains (3) summary
    COG5048
    Location:202 → 634
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:458 → 478
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 48
    KRAB; KRAB box

  2. XM_011527285.3 → XP_011525587.1  zinc finger protein 225 isoform X1

    See identical proteins and their annotated locations for XP_011525587.1

    UniProtKB/Swiss-Prot
    A8K8S2, Q53F12, Q9NS46, Q9UID8, Q9UK10
    Conserved Domains (3) summary
    COG5048
    Location:202 → 634
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:458 → 478
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 48
    KRAB; KRAB box

  3. XM_005259223.4 → XP_005259280.1  zinc finger protein 225 isoform X2

    See identical proteins and their annotated locations for XP_005259280.1

    Conserved Domains (3) summary
    COG5048
    Location:119 → 551
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:375 → 395
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:135 → 160
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46934319..46957717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322028.1 → XP_054178003.1  zinc finger protein 225 isoform X1

    UniProtKB/Swiss-Prot
    A8K8S2, Q53F12, Q9NS46, Q9UID8, Q9UK10

  2. XM_054322027.1 → XP_054178002.1  zinc finger protein 225 isoform X1

    UniProtKB/Swiss-Prot
    A8K8S2, Q53F12, Q9NS46, Q9UID8, Q9UK10

  3. XM_054322029.1 → XP_054178004.1  zinc finger protein 225 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UK10.2 GenPept UniProtKB/Swiss-Prot:Q9UK10

Gene LinkOut

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