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Trat1 T cell receptor associated transmembrane adaptor 1 [ Mus musculus (house mouse) ]

Gene ID: 77647, updated on 5-Mar-2024

Summary

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Official Symbol
Trat1provided by MGI
Official Full Name
T cell receptor associated transmembrane adaptor 1provided by MGI
Primary source
MGI:MGI:1924897
See related
Ensembl:ENSMUSG00000030775 AllianceGenome:MGI:1924897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trim; Tcrim; C030046M14Rik
Summary
Predicted to be involved in negative regulation of receptor recycling and positive regulation of T cell receptor signaling pathway. Predicted to act upstream of or within negative regulation of transport and positive regulation of calcium-mediated signaling. Predicted to be located in centriolar satellite; mitotic spindle; and plasma membrane. Predicted to be part of T cell receptor complex. Orthologous to human TRAT1 (T cell receptor associated transmembrane adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 5.3) and mammary gland adult (RPKM 0.2) See more
Orthologs
human all
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Genomic context

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Location:
16 B5; 16 30.75 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (48551137..48630883, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (48730774..48810547, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40947 Neighboring gene predicted gene 5485 Neighboring gene microrchidia 1 Neighboring gene STARR-seq mESC enhancer starr_40948 Neighboring gene STARR-seq mESC enhancer starr_40950 Neighboring gene STARR-seq mESC enhancer starr_40952 Neighboring gene STARR-seq mESC enhancer starr_40956 Neighboring gene STARR-seq mESC enhancer starr_40960 Neighboring gene predicted gene, 41458 Neighboring gene TWIST neighbor pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:48788868-48789191 Neighboring gene resistin like beta Neighboring gene resistin like alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Normal T-cell development and immune functions in TRIM-deficient mice. Kölsch U, et al. Mol Cell Biol, 2006 May. PMID 16612002, Free PMC Article
  2. Developmentally regulated expression of the transmembrane adaptor protein trim in fetal and adult T cells. Huynh T, et al. Scand J Immunol, 2001 Jul-Aug. PMID 11439161
  3. SIT and TRIM determine T cell fate in the thymus. Koelsch U, et al. J Immunol, 2008 Nov 1. PMID 18941181
  4. The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. Kirchgessner H, et al. J Exp Med, 2001 Jun 4. PMID 11390434, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC129418, MGC129419

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of receptor recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
part_of T cell receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of T cell receptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
T-cell receptor-associated transmembrane adapter 1
Names
T-cell receptor-interacting molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198297.4 → NP_938039.3  T-cell receptor-associated transmembrane adapter 1

    Status: VALIDATED

    Source sequence(s)
    AC166114
    Consensus CDS
    CCDS37352.1
    UniProtKB/Swiss-Prot
    Q3SXD9, Q3SXE0, Q3UU67
    UniProtKB/TrEMBL
    A0A338P6G9
    Related
    ENSMUSP00000155986.3, ENSMUST00000231701.3
    Conserved Domains (1) summary
    pfam15330
    Location:23 → 121
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    48551137..48630883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522730.5 → XP_006522793.1  T-cell receptor-associated transmembrane adapter 1 isoform X1

    UniProtKB/TrEMBL
    A0A338P6G9
    Conserved Domains (1) summary
    pfam15330
    Location:72 → 170
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

  2. XM_006522732.3 → XP_006522795.1  T-cell receptor-associated transmembrane adapter 1 isoform X2

    See identical proteins and their annotated locations for XP_006522795.1

    UniProtKB/Swiss-Prot
    Q3UU67
    Conserved Domains (1) summary
    pfam15330
    Location:35 → 103
    SIT; SHP2-interacting transmembrane adaptor protein, SIT
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UU67.2 GenPept UniProtKB/Swiss-Prot:Q3UU67

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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