U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Steep1 STING1 ER exit protein 1 [ Mus musculus (house mouse) ]

Gene ID: 77644, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Steep1provided by MGI
Official Full Name
STING1 ER exit protein 1provided by MGI
Primary source
MGI:MGI:1924894
See related
Ensembl:ENSMUSG00000006423 AllianceGenome:MGI:1924894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
STEEP; C330007P06Rik
Summary
Predicted to be involved in endoplasmic reticulum membrane organization and endoplasmic reticulum to Golgi vesicle-mediated transport. Located in cell body and nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 107. Orthologous to human STEEP1 (STING1 ER exit protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.6), cerebellum adult (RPKM 5.2) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
X A3.3; X 21.23 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (36087388..36127956, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (36827161..36864303, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 Neighboring gene STARR-seq mESC enhancer starr_47002 Neighboring gene STARR-seq mESC enhancer starr_47003 Neighboring gene mitochondrial dynamic related lncRNA Neighboring gene STARR-seq mESC enhancer starr_47006 Neighboring gene 60S ribosomal protein L39 pseudogene Neighboring gene ubiquitin-conjugating enzyme E2A Neighboring gene NF-kappaB repressing factor Neighboring gene STARR-positive B cell enhancer ABC_E11047

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CXorf56, a dendritic neuronal protein, identified as a new candidate gene for X-linked intellectual disability. Verkerk AJMH, et al. Eur J Hum Genet, 2018 Apr. PMID 29374277, Free PMC Article
  2. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article
  3. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
  4. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein exit from endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
STING ER exit protein
Names
UPF0428 protein CXorf56 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029951.1 → NP_084227.1  STING ER exit protein

    See identical proteins and their annotated locations for NP_084227.1

    Status: VALIDATED

    Source sequence(s)
    AK035825, AK036910, BB622061, D18428
    Consensus CDS
    CCDS53050.1
    UniProtKB/Swiss-Prot
    A2A3V4, Q3URC0, Q8C8Z1, Q8VDP2, Q9CWC1
    UniProtKB/TrEMBL
    Z4YLD0
    Related
    ENSMUSP00000110903.4, ENSMUST00000115248.10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    36087388..36127956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541410.5 → XP_006541473.1  STING ER exit protein isoform X1

    UniProtKB/TrEMBL
    Z4YLD0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDP2.1 GenPept UniProtKB/Swiss-Prot:Q8VDP2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous