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Prss36 serine protease 36 [ Mus musculus (house mouse) ]

Gene ID: 77613, updated on 5-Mar-2024

Summary

Official Symbol
Prss36provided by MGI
Official Full Name
serine protease 36provided by MGI
Primary source
MGI:MGI:1924863
See related
Ensembl:ENSMUSG00000070371 AllianceGenome:MGI:1924863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C330007D15Rik
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in cytoplasm. Is expressed in embryo. Orthologous to human PRSS36 (serine protease 36). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 4.9), mammary gland adult (RPKM 4.9) and 28 other tissues See more
Orthologs
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Genomic context

Location:
7 F3; 7 69.84 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127531810..127545897, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127932638..127946725, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11370 Neighboring gene branched chain ketoacid dehydrogenase kinase Neighboring gene STARR-seq mESC enhancer starr_20195 Neighboring gene K(lysine) acetyltransferase 8 Neighboring gene serine protease 8 (prostasin) Neighboring gene STARR-positive B cell enhancer ABC_E6608 Neighboring gene predicted gene, 53375 Neighboring gene STARR-seq mESC enhancer starr_20197 Neighboring gene fused in sarcoma Neighboring gene PYD and CARD domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
polyserase-2
Names
polyserase-2 protein
polyserine protease 2
protease, serine 36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319147.1NP_001306076.1  polyserase-2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC149222
    Consensus CDS
    CCDS52410.2
    UniProtKB/Swiss-Prot
    Q5K2P8
    UniProtKB/TrEMBL
    E9QJT0
    Related
    ENSMUSP00000112659.2, ENSMUST00000118755.8
    Conserved Domains (4) summary
    smart00020
    Location:47287
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:48290
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00089
    Location:327457
    Trypsin; Trypsin
    cl21584
    Location:596778
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    127531810..127545897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312395.3XP_017167884.1  polyserase-2 isoform X17

    UniProtKB/Swiss-Prot
    Q5K2P8
    UniProtKB/TrEMBL
    D3YV46
    Related
    ENSMUSP00000091565.4, ENSMUST00000094026.10
    Conserved Domains (2) summary
    cd00190
    Location:48290
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:607789
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_017312388.2XP_017167877.1  polyserase-2 isoform X8

    Conserved Domains (2) summary
    cd00190
    Location:1171
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:371553
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_017312387.2XP_017167876.1  polyserase-2 isoform X5

    Conserved Domains (2) summary
    cd00190
    Location:1171
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:396578
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  4. XM_036153559.1XP_036009452.1  polyserase-2 isoform X4

    Conserved Domains (2) summary
    cd00190
    Location:1171
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:429611
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  5. XM_030243097.1XP_030098957.1  polyserase-2 isoform X2

    UniProtKB/Swiss-Prot
    Q5K2P8
    Conserved Domains (2) summary
    cd00190
    Location:1171
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:494676
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  6. XM_036153560.1XP_036009453.1  polyserase-2 isoform X11

    Conserved Domains (2) summary
    cd00190
    Location:1171
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:212321
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  7. XM_030243100.1XP_030098960.1  polyserase-2 isoform X7

    Conserved Domains (2) summary
    cd00190
    Location:1171
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00089
    Location:208321
    Trypsin
  8. XM_036153561.1XP_036009454.1  polyserase-2 isoform X12

    Conserved Domains (2) summary
    cd00190
    Location:1171
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:212321
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  9. XM_030243103.1XP_030098963.1  polyserase-2 isoform X13

    Conserved Domains (2) summary
    cd00190
    Location:1171
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:212321
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  10. XM_030243101.1XP_030098961.1  polyserase-2 isoform X9

    Conserved Domains (2) summary
    cd00190
    Location:1171
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:212321
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  11. XM_030243098.1XP_030098958.1  polyserase-2 isoform X3

    UniProtKB/Swiss-Prot
    Q5K2P8
    Conserved Domains (2) summary
    cd00190
    Location:1171
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:487669
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  12. XM_030243099.1XP_030098959.1  polyserase-2 isoform X6

    Conserved Domains (2) summary
    cd00190
    Location:1171
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:212321
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  13. XM_030243102.1XP_030098962.1  polyserase-2 isoform X10

    Conserved Domains (2) summary
    cd00190
    Location:1171
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:212321
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  14. XM_030243095.1XP_030098955.1  polyserase-2 isoform X1

    UniProtKB/Swiss-Prot
    Q5K2P8
    Conserved Domains (2) summary
    cd00190
    Location:1171
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:527709
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  15. XM_030243106.1XP_030098966.1  polyserase-2 isoform X15

    Conserved Domains (1) summary
    cl21584
    Location:184366
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  16. XM_030243105.1XP_030098965.1  polyserase-2 isoform X14

    Conserved Domains (2) summary
    cd00190
    Location:1171
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:212321
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  17. XM_036153562.1XP_036009455.1  polyserase-2 isoform X16

    Conserved Domains (2) summary
    cd00190
    Location:1171
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl21584
    Location:212321
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

  1. XR_004934211.1 RNA Sequence

  2. XR_003946593.1 RNA Sequence

  3. XR_003946595.1 RNA Sequence

  4. XR_003946592.1 RNA Sequence

  5. XR_003946594.1 RNA Sequence

  6. XR_003946591.1 RNA Sequence

  7. XR_003946596.1 RNA Sequence

  8. XR_004934210.1 RNA Sequence

  9. XR_004934214.1 RNA Sequence

  10. XR_004934216.1 RNA Sequence

  11. XR_004934213.1 RNA Sequence

  12. XR_004934215.1 RNA Sequence

  13. XR_004934212.1 RNA Sequence

  14. XR_004934217.1 RNA Sequence

  15. XR_003946585.1 RNA Sequence

  16. XR_003946588.1 RNA Sequence

  17. XR_003946584.1 RNA Sequence

  18. XR_003946586.1 RNA Sequence

  19. XR_004934209.1 RNA Sequence

  20. XR_004934208.1 RNA Sequence

  21. XR_004934207.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081374.1: Suppressed sequence

    Description
    NM_001081374.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.