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Usp45 ubiquitin specific petidase 45 [ Mus musculus (house mouse) ]

Gene ID: 77593, updated on 5-Mar-2024

Summary

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Official Symbol
Usp45provided by MGI
Official Full Name
ubiquitin specific petidase 45provided by MGI
Primary source
MGI:MGI:101850
See related
Ensembl:ENSMUSG00000040455 AllianceGenome:MGI:101850
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gcap7; 3110003C05Rik; 4930550B20Rik
Summary
Predicted to enable thiol-dependent deubiquitinase. Involved in photoreceptor cell maintenance. Predicted to be located in cytoplasm; nucleus; and photoreceptor inner segment. Human ortholog(s) of this gene implicated in Leber congenital amaurosis. Orthologous to human USP45 (ubiquitin specific peptidase 45). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 6.8), liver E14.5 (RPKM 5.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A3; 4 8.93 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (21767161..21837872)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (21767161..21837872)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene PR domain containing 13 Neighboring gene STARR-seq mESC enhancer starr_09729 Neighboring gene STARR-seq mESC enhancer starr_09730 Neighboring gene cyclin C Neighboring gene STARR-positive B cell enhancer ABC_E3481 Neighboring gene STARR-seq mESC enhancer starr_09732 Neighboring gene STARR-seq mESC enhancer starr_09733 Neighboring gene thiosulfate sulfurtransferase (rhodanese)-like domain containing 3 Neighboring gene RIKEN cDNA 4930528A17 gene Neighboring gene STARR-seq mESC enhancer starr_09734 Neighboring gene PNN interacting serine/arginine-rich Neighboring gene coenzyme Q3 methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Biallelic mutations in USP45, encoding a deubiquitinating enzyme, are associated with Leber congenital amaurosis. Yi Z, et al. J Med Genet, 2019 May. PMID 30573563
  2. USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses. Perez-Oliva AB, et al. EMBO J, 2015 Feb 3. PMID 25538220, Free PMC Article
  3. Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library. Kambouris M, et al. Brain Res Mol Brain Res, 1994 Sep. PMID 7808216
  4. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article
  5. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these results establish USP45 as a new regulator of XPF-ERCC1 crucial for efficient DNA repair
    Title: USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (6)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • RP23-38K18.3

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in photoreceptor cell maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 45
Names
deubiquitinating enzyme 45
granule cell antiserum positive 7
ubiquitin specific protease 45
ubiquitin thioesterase 45
ubiquitin thiolesterase 45
ubiquitin-specific-processing protease 45
NP_001277354.1
NP_690038.1
XP_006538424.1
XP_006538425.1
XP_011248434.1
XP_030109769.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290425.1 → NP_001277354.1  ubiquitin carboxyl-terminal hydrolase 45 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AI465456, AK019756, AL772187, BB213271
    Consensus CDS
    CCDS71351.1
    UniProtKB/Swiss-Prot
    Q8K387
    Related
    ENSMUSP00000048324.6, ENSMUST00000040429.12
    Conserved Domains (3) summary
    cd02667
    Location:192 → 762
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:192 → 761
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:62 → 132
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  2. NM_152825.2 → NP_690038.1  ubiquitin carboxyl-terminal hydrolase 45 isoform 1

    See identical proteins and their annotated locations for NP_690038.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI465456, AK019756, AK040660, AL772187, BM227454
    Consensus CDS
    CCDS38700.1
    UniProtKB/Swiss-Prot
    A2AJT1, Q8BU19, Q8BZ19, Q8K387
    Related
    ENSMUSP00000067109.9, ENSMUST00000065111.15
    Conserved Domains (3) summary
    COG5207
    Location:72 → 359
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd02667
    Location:587 → 810
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:192 → 388
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    21767161..21837872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250132.1 → XP_011248434.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X1

    See identical proteins and their annotated locations for XP_011248434.1

    UniProtKB/Swiss-Prot
    A2AJT1, Q8BU19, Q8BZ19, Q8K387
    Conserved Domains (3) summary
    COG5207
    Location:72 → 359
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd02667
    Location:587 → 810
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:192 → 388
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

  2. XM_006538362.1 → XP_006538425.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X2

    Conserved Domains (3) summary
    COG5207
    Location:71 → 358
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd02667
    Location:586 → 809
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:191 → 387
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

  3. XM_030253909.1 → XP_030109769.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X3

    Conserved Domains (3) summary
    COG5560
    Location:192 → 713
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cl02553
    Location:192 → 388
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam02148
    Location:62 → 132
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  4. XM_006538361.5 → XP_006538424.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X1

    See identical proteins and their annotated locations for XP_006538424.1

    UniProtKB/Swiss-Prot
    A2AJT1, Q8BU19, Q8BZ19, Q8K387
    Conserved Domains (3) summary
    COG5207
    Location:72 → 359
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd02667
    Location:587 → 810
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:192 → 388
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

RNA

  1. XR_004942010.1 RNA Sequence

    Related
    ENSMUST00000137293.8

  2. XR_004942011.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K387.1 GenPept UniProtKB/Swiss-Prot:Q8K387

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