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Ddx10 DEAD box helicase 10 [ Mus musculus (house mouse) ]

Gene ID: 77591, updated on 21-Apr-2024

Summary

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Official Symbol
Ddx10provided by MGI
Official Full Name
DEAD box helicase 10provided by MGI
Primary source
MGI:MGI:1924841
See related
Ensembl:ENSMUSG00000053289 AllianceGenome:MGI:1924841
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4632415A01Rik
Summary
Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Acts upstream of or within anterior head development. Predicted to be active in nucleus. Orthologous to human DDX10 (DEAD-box helicase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 4.2), liver E14 (RPKM 2.9) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.3; 9 29.12 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (53009754..53159423, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (53098454..53248170, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 1715 Neighboring gene STARR-seq mESC enhancer starr_24139 Neighboring gene predicted gene, 53523 Neighboring gene predicted gene, 39339 Neighboring gene STARR-positive B cell enhancer ABC_E1786 Neighboring gene STARR-seq mESC enhancer starr_24140 Neighboring gene STARR-seq mESC enhancer starr_24141 Neighboring gene exophilin 5 Neighboring gene protein O-glucosyltransferase 3 Neighboring gene microRNA 130c

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology. Palmer K, et al. Dev Biol, 2016 Jul 15. PMID 26234751, Free PMC Article
  2. Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Fairfield H, et al. Genome Res, 2015 Jul. PMID 25917818, Free PMC Article
  3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC91294

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anterior head development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DDX10
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEAD box protein 10
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase)
NP_084212.2
XP_006510747.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029936.2 → NP_084212.2  probable ATP-dependent RNA helicase DDX10

    See identical proteins and their annotated locations for NP_084212.2

    Status: VALIDATED

    Source sequence(s)
    AC112956, AC160139
    Consensus CDS
    CCDS52796.1
    UniProtKB/Swiss-Prot
    Q80Y44
    UniProtKB/TrEMBL
    Q66JW6
    Related
    ENSMUSP00000065198.7, ENSMUST00000065630.8
    Conserved Domains (4) summary
    PRK04837
    Location:69 → 450
    PRK04837; ATP-dependent RNA helicase RhlB; Provisional
    cd00079
    Location:288 → 418
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:71 → 275
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam13959
    Location:451 → 510
    DUF4217; Domain of unknown function (DUF4217)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    53009754..53159423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510684.5 → XP_006510747.1  probable ATP-dependent RNA helicase DDX10 isoform X1

    UniProtKB/TrEMBL
    Q8BRE3
    Conserved Domains (2) summary
    PRK01297
    Location:13 → 413
    PRK01297; ATP-dependent RNA helicase RhlB; Provisional
    cd17941
    Location:80 → 277
    DEADc_DDX10; DEAD-box helicase domain of DEAD box protein 10
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80Y44.2 GenPept UniProtKB/Swiss-Prot:Q80Y44

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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