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Bcl9 B cell CLL/lymphoma 9 [ Mus musculus (house mouse) ]

Gene ID: 77578, updated on 14-Apr-2024

Summary

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Official Symbol
Bcl9provided by MGI
Official Full Name
B cell CLL/lymphoma 9provided by MGI
Primary source
MGI:MGI:1924828
See related
Ensembl:ENSMUSG00000038256 AllianceGenome:MGI:1924828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm130; 2610202E01Rik; 8030475K17Rik; A330041G23Rik
Summary
Enables beta-catenin binding activity. Acts upstream of or within several processes, including myotube differentiation involved in skeletal muscle regeneration; skeletal muscle cell differentiation; and somatic stem cell population maintenance. Located in cis-Golgi network and nucleus. Is expressed in several structures, including brain; eye; head surface ectoderm; metanephros; and thymus primordium. Orthologous to human BCL9 (BCL9 transcription coactivator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 13.7), CNS E11.5 (RPKM 12.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Bcl9 in Genome Data Viewer
Location:
3 F2.1; 3 42.04 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (97110974..97205718, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (97203658..97298402, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08461 Neighboring gene STARR-seq mESC enhancer starr_08462 Neighboring gene nuclear encoded tRNA glutamic acid 12 (anticodon CTC) Neighboring gene acid phosphatase 6, lysophosphatidic Neighboring gene STARR-seq mESC enhancer starr_08463 Neighboring gene STARR-positive B cell enhancer mm9_chr3:97031479-97031779 Neighboring gene STARR-seq mESC enhancer starr_08464 Neighboring gene predicted gene, 40101 Neighboring gene olfactory receptor family 13 subfamily L member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. miRNA-122-5p in POI ovarian-derived exosomes promotes granulosa cell apoptosis by regulating BCL9. Zhang X, et al. Cancer Med, 2022 Jun. PMID 35229987, Free PMC Article
  2. Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells. Borrelli C, et al. Nat Commun, 2021 Mar 1. PMID 33649334, Free PMC Article
  3. BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer. Feng M, et al. Signal Transduct Target Ther, 2021 Aug 20. PMID 34417435, Free PMC Article
  4. BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer. Wang X, et al. Oncogene, 2021 Apr. PMID 33767438
  5. TMF/ARA160: A key regulator of sperm development. Lerer-Goldshtein T, et al. Dev Biol, 2010 Dec 1. PMID 20691678

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miRNA-122-5p in POI ovarian-derived exosomes promotes granulosa cell apoptosis by regulating BCL9.
    Title: miRNA-122-5p in POI ovarian-derived exosomes promotes granulosa cell apoptosis by regulating BCL9.
  2. BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer.
    Title: BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer.
  3. BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.
    Title: BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.
  4. TBX3 acts as tissue-specific component of the Wnt/beta-catenin transcriptional complex.
    Title: TBX3 acts as tissue-specific component of the Wnt/β-catenin transcriptional complex.
  5. Transcriptional cofactors Bcl9, Bcl9l and Pygo1/2 act independently of beta-catenin to ensure proper enamel formation.
    Title: A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.
  6. ARX positively regulates Wnt/ beta-catenin signaling and the C-terminal domain of ARX interacts with the armadillo repeats in beta-catenin to promote Wnt/beta-catenin signaling. In addition, we found BCL9 and P300 also interact with ARX to modulate Wnt/beta-catenin signaling.
    Title: Aristaless Related Homeobox (ARX) Interacts with β-Catenin, BCL9, and P300 to Regulate Canonical Wnt Signaling.
  7. Study demonstrates that the Golgi resident protein GM130 activates the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and further captures them to couple mitotic membranes to the spindle.
    Title: GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules.
  8. Pax6, the master regulator of eye development, directly activates Bcl9/9l transcription.
    Title: Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development.
  9. These results suggest a critical role of BCL9/9-2 in the Wnt-mediated regulation of adult, as opposed to embryonic, myogenic progenitors.
    Title: BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within myoblast differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within myotube differentiation involved in skeletal muscle regeneration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within somatic stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of beta-catenin-TCF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of beta-catenin-TCF complex ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
B-cell CLL/lymphoma 9 protein
Names
B-cell lymphoma 9 protein
bcl-9
nuclear co-factor of beta-catenin signalling

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429224.1 → NP_001416153.1  B-cell CLL/lymphoma 9 protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140071

  2. NM_001429225.1 → NP_001416154.1  B-cell CLL/lymphoma 9 protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140071

  3. NM_001429226.1 → NP_001416155.1  B-cell CLL/lymphoma 9 protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140071

  4. NM_001429227.1 → NP_001416156.1  B-cell CLL/lymphoma 9 protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140071

  5. NM_029933.5 → NP_084209.3  B-cell CLL/lymphoma 9 protein isoform 1

    See identical proteins and their annotated locations for NP_084209.3

    Status: VALIDATED

    Source sequence(s)
    AC140071
    Consensus CDS
    CCDS17654.1
    UniProtKB/Swiss-Prot
    B2RQC0, Q67FX9, Q8BUJ8, Q8VE74, Q9D219
    Related
    ENSMUSP00000046152.8, ENSMUST00000046521.14
    Conserved Domains (2) summary
    PHA03247
    Location:570 → 1160
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:350 → 388
    BCL9; B-cell lymphoma 9 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    97110974..97205718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502288.4 → XP_006502351.1  B-cell CLL/lymphoma 9 protein isoform X1

    UniProtKB/Swiss-Prot
    B2RQC0, Q67FX9, Q8BUJ8, Q8VE74, Q9D219
    Conserved Domains (2) summary
    PHA03247
    Location:570 → 1160
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:350 → 388
    BCL9; B-cell lymphoma 9 protein

  2. XM_030252892.2 → XP_030108752.1  B-cell CLL/lymphoma 9 protein isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:496 → 1086
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:276 → 314
    BCL9; B-cell lymphoma 9 protein

  3. XM_006502290.4 → XP_006502353.1  B-cell CLL/lymphoma 9 protein isoform X1

    See identical proteins and their annotated locations for XP_006502353.1

    UniProtKB/Swiss-Prot
    B2RQC0, Q67FX9, Q8BUJ8, Q8VE74, Q9D219
    Conserved Domains (2) summary
    PHA03247
    Location:570 → 1160
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:350 → 388
    BCL9; B-cell lymphoma 9 protein

  4. XM_036163404.1 → XP_036019297.1  B-cell CLL/lymphoma 9 protein isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:496 → 1086
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:276 → 314
    BCL9; B-cell lymphoma 9 protein

  5. XM_006502292.5 → XP_006502355.1  B-cell CLL/lymphoma 9 protein isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:496 → 1086
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:276 → 314
    BCL9; B-cell lymphoma 9 protein

  6. XM_006502289.5 → XP_006502352.1  B-cell CLL/lymphoma 9 protein isoform X1

    UniProtKB/Swiss-Prot
    B2RQC0, Q67FX9, Q8BUJ8, Q8VE74, Q9D219
    Related
    ENSMUSP00000131692.2, ENSMUST00000166341.2
    Conserved Domains (2) summary
    PHA03247
    Location:570 → 1160
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:350 → 388
    BCL9; B-cell lymphoma 9 protein

  7. XM_030252891.1 → XP_030108751.1  B-cell CLL/lymphoma 9 protein isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:570 → 1148
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:350 → 388
    BCL9; B-cell lymphoma 9 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D219.3 GenPept UniProtKB/Swiss-Prot:Q9D219

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