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Spns3 SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative) [ Mus musculus (house mouse) ]

Gene ID: 77577, updated on 21-Apr-2024

Summary

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Official Symbol
Spns3provided by MGI
Official Full Name
SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)provided by MGI
Primary source
MGI:MGI:1924827
See related
Ensembl:ENSMUSG00000020798 AllianceGenome:MGI:1924827
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9830002I17Rik
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to act upstream of or within lipid transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human SPNS3 (sphingolipid transporter 3 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 8.8), thymus adult (RPKM 4.2) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B4; 11 44.34 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72388979..72441334, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72498153..72550509, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8422 Neighboring gene MYB binding protein (P160) 1a Neighboring gene Spns2 opposite strand Neighboring gene SPNS lysolipid transporter 2, sphingosine-1-phosphate Neighboring gene STARR-seq mESC enhancer starr_29912 Neighboring gene STARR-positive B cell enhancer ABC_E8423 Neighboring gene STARR-seq mESC enhancer starr_29914 Neighboring gene predicted gene, 51906 Neighboring gene predicted gene 12712 Neighboring gene STARR-positive B cell enhancer ABC_E2360 Neighboring gene STARR-positive B cell enhancer ABC_E5245 Neighboring gene ubiquitin-conjugating enzyme E2G 1 Neighboring gene predicted gene, 24143

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Jacobsson JA, et al. Genomics, 2007 Nov. PMID 17714910
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein spinster homolog 3
Names
spinster homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029932.3 → NP_084208.1  protein spinster homolog 3

    See identical proteins and their annotated locations for NP_084208.1

    Status: PROVISIONAL

    Source sequence(s)
    AL662812
    Consensus CDS
    CCDS24987.1
    UniProtKB/Swiss-Prot
    B2RX04, Q3U0X5, Q8BYA9, Q9D232
    Related
    ENSMUSP00000090617.7, ENSMUST00000092940.13
    Conserved Domains (2) summary
    cd06174
    Location:53 → 470
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:55 → 418
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    72388979..72441334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534486.1 → XP_006534549.1  protein spinster homolog 3 isoform X1

    Conserved Domains (1) summary
    cd17328
    Location:53 → 447
    MFS_spinster_like; Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters

  2. XM_011249311.1 → XP_011247613.1  protein spinster homolog 3 isoform X2

    See identical proteins and their annotated locations for XP_011247613.1

    Conserved Domains (1) summary
    cd17328
    Location:16 → 257
    MFS_spinster_like; Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters

  3. XM_006534488.5 → XP_006534551.1  protein spinster homolog 3 isoform X2

    See identical proteins and their annotated locations for XP_006534551.1

    Conserved Domains (1) summary
    cd17328
    Location:16 → 257
    MFS_spinster_like; Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters

RNA

  1. XR_388557.4 RNA Sequence

  2. XR_388556.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D232.1 GenPept UniProtKB/Swiss-Prot:Q9D232

Gene LinkOut

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