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Tcaf1 TRPM8 channel-associated factor 1 [ Mus musculus (house mouse) ]

Gene ID: 77574, updated on 5-Mar-2024

Summary

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Official Symbol
Tcaf1provided by MGI
Official Full Name
TRPM8 channel-associated factor 1provided by MGI
Primary source
MGI:MGI:1914665
See related
Ensembl:ENSMUSG00000036667 AllianceGenome:MGI:1914665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam115a; 2810407D09Rik; 3321401G04Rik; A230020K05Rik
Summary
Predicted to enable transmembrane transporter binding activity. Predicted to be involved in negative regulation of cell migration; positive regulation of anion channel activity; and positive regulation of protein targeting to membrane. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in nervous system and neural retina. Orthologous to human TCAF1 (TRPM8 channel associated factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 35.3), CNS E14 (RPKM 32.0) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B2.1; 6 20.84 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (42644933..42687065, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (42667999..42710131, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene TRPM8 channel-associated factor 3 Neighboring gene TRPM8 channel-associated factor 2 Neighboring gene STARR-seq mESC enhancer starr_15722 Neighboring gene olfactory receptor family 2 subfamily AR member 1, pseudogene 1 Neighboring gene 40S ribosomal protein S23 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. Gkika D, et al. J Cell Biol, 2015 Jan 5. PMID 25559186, Free PMC Article
  2. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Report novel TRP channel-associated factors that modulate TRPM8 activity.
    Title: TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0738

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of anion channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
TRPM8 channel-associated factor 1
Names
TRP channel-associated factor 1
family with sequence similarity 115, member A
protein FAM115A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355768.1 → NP_001342697.1  TRPM8 channel-associated factor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK014379, AK132148, BM117796
    UniProtKB/Swiss-Prot
    Q6A005, Q80VG2, Q8BNE1, Q8BPR4, Q8BTD3, Q8C8Q5, Q8CEM1, Q8CET9, Q8K2D7, Q9D223
    Conserved Domains (2) summary
    pfam13402
    Location:633 → 892
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
    pfam17291
    Location:522 → 631
    M60-like_N; N-terminal domain of M60-like peptidases

  2. NM_001355769.1 → NP_001342698.1  TRPM8 channel-associated factor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC155334
    Consensus CDS
    CCDS20076.1
    Related
    ENSMUSP00000046137.5, ENSMUST00000045054.11
    Conserved Domains (2) summary
    pfam13402
    Location:633 → 892
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
    pfam17291
    Location:522 → 631
    M60-like_N; N-terminal domain of M60-like peptidases

  3. NM_001355770.1 → NP_001342699.1  TRPM8 channel-associated factor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC155334
    Consensus CDS
    CCDS20076.1
    Conserved Domains (2) summary
    pfam13402
    Location:633 → 892
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
    pfam17291
    Location:522 → 631
    M60-like_N; N-terminal domain of M60-like peptidases

  4. NM_029930.3 → NP_084206.1  TRPM8 channel-associated factor 1 isoform 2

    See identical proteins and their annotated locations for NP_084206.1

    Status: VALIDATED

    Source sequence(s)
    AK053509, BY324097
    Consensus CDS
    CCDS20076.1
    UniProtKB/Swiss-Prot
    Q8BNE1
    Related
    ENSMUSP00000036379.5, ENSMUST00000045140.5
    Conserved Domains (2) summary
    pfam13402
    Location:633 → 892
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
    pfam17291
    Location:522 → 631
    M60-like_N; N-terminal domain of M60-like peptidases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    42644933..42687065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506752.4 → XP_006506815.1  TRPM8 channel-associated factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006506815.1

    UniProtKB/Swiss-Prot
    Q6A005, Q80VG2, Q8BNE1, Q8BPR4, Q8BTD3, Q8C8Q5, Q8CEM1, Q8CET9, Q8K2D7, Q9D223
    Conserved Domains (2) summary
    pfam13402
    Location:633 → 892
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
    pfam17291
    Location:522 → 631
    M60-like_N; N-terminal domain of M60-like peptidases

  2. XM_006506754.4 → XP_006506817.1  TRPM8 channel-associated factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006506817.1

    UniProtKB/Swiss-Prot
    Q6A005, Q80VG2, Q8BNE1, Q8BPR4, Q8BTD3, Q8C8Q5, Q8CEM1, Q8CET9, Q8K2D7, Q9D223
    Conserved Domains (2) summary
    pfam13402
    Location:633 → 892
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
    pfam17291
    Location:522 → 631
    M60-like_N; N-terminal domain of M60-like peptidases

  3. XM_036152394.1 → XP_036008287.1  TRPM8 channel-associated factor 1 isoform X2

    Conserved Domains (2) summary
    pfam13402
    Location:633 → 892
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
    pfam17291
    Location:522 → 631
    M60-like_N; N-terminal domain of M60-like peptidases

  4. XM_006506753.5 → XP_006506816.1  TRPM8 channel-associated factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006506816.1

    UniProtKB/Swiss-Prot
    Q6A005, Q80VG2, Q8BNE1, Q8BPR4, Q8BTD3, Q8C8Q5, Q8CEM1, Q8CET9, Q8K2D7, Q9D223
    Conserved Domains (2) summary
    pfam13402
    Location:633 → 892
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
    pfam17291
    Location:522 → 631
    M60-like_N; N-terminal domain of M60-like peptidases

  5. XM_006506756.4 → XP_006506819.1  TRPM8 channel-associated factor 1 isoform X2

    See identical proteins and their annotated locations for XP_006506819.1

    UniProtKB/Swiss-Prot
    Q8BNE1
    Related
    ENSMUSP00000114036.2, ENSMUST00000121083.8
    Conserved Domains (2) summary
    pfam13402
    Location:633 → 892
    Peptidase_M60; Peptidase M60, enhancin and enhancin-like
    pfam17291
    Location:522 → 631
    M60-like_N; N-terminal domain of M60-like peptidases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BNE1.1 GenPept UniProtKB/Swiss-Prot:Q8BNE1

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